have similar efficacy with a more favorable toxicity profile than sunitinib, with lower rates of hand-foot syndrome, fatigue, and neutropenia, but higher rates of hypertension and hepatic enzyme elevation. 12 , 19 This hypothesis has been tested in a
Search Results
Selecting Targeted Therapies for Patients With Renal Cell Carcinoma
Elizabeth R. Plimack and Gary R. Hudes
NCCN Guidelines Insights: Multiple Myeloma, Version 1.2020
Featured Updates to the NCCN Guidelines
Shaji K. Kumar, Natalie S. Callander, Jens Hillengass, Michaela Liedtke, Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, Jason C. Chandler, Robert F. Cornell, Caitlin Costello, Yvonne Efebera, Matthew Faiman, Alfred Garfall, Kelly Godby, Leona Holmberg, Myo Htut, Carol Ann Huff, Yubin Kang, Ola Landgren, Ehsan Malek, Thomas Martin, James Omel, Noopur Raje, Douglas Sborov, Seema Singhal, Keith Stockerl-Goldstein, Carlyn Tan, Donna Weber, Alyse Johnson-Chilla, Jennifer Keller, and Rashmi Kumar
%). 21 Rates of pneumonia, neutropenia, and leukopenia were higher in patients receiving daratumumab. 21 Based on the results of this study, the FDA approved the use of daratumumab/lenalidomide/dexamethasone in this setting. Carfilzomib
Who Benefits From Maintenance Therapy in Acute Promyelocytic Leukemia?
Edmond Marzbani and Elihu Estey
, 6 patients were admitted for febrile neutropenia, and 3 cases of nonfatal Pneumocystis jiroveci were seen. 13 , 14 In a Japanese case series of 10 patients, a less-intensive regimen of ATRA, 6-MP, and MTX was used for maintenance, and no patients
Prostate Cancer, Version 1.2014
James L. Mohler, Philip W. Kantoff, Andrew J. Armstrong, Robert R. Bahnson, Michael Cohen, Anthony Victor D’Amico, James A. Eastham, Charles A. Enke, Thomas A. Farrington, Celestia S. Higano, Eric Mark Horwitz, Mark H. Kawachi, Michael Kuettel, Richard J. Lee, Gary R. MacVicar, Arnold W. Malcolm, David Miller, Elizabeth R. Plimack, Julio M. Pow-Sang, Sylvia Richey, Mack Roach III, Eric Rohren, Stan Rosenfeld, Eric J. Small, Sandy Srinivas, Cy Stein, Seth A. Strope, Jonathan Tward, Patrick C. Walsh, Dorothy A. Shead, and Maria Ho
Radium-223 was well tolerated. Grade 3/4 hematologic toxicity was low (3% neutropenia, 6% thrombocytopenia, and 13% anemia), possibly because of the short range of radioactivity. 23 Fecal elimination of the agent led to generally mild nonhematologic side
Focal Takotsubo Cardiomyopathy With High-Dose Interleukin-2 Therapy for Malignant Melanoma
Senthil Damodaran, Ewa Mrozek, David Liebner, and Kari Kendra
duration of 1 year. Therapy was well tolerated except for the development of flu-like symptoms, nausea, and fatigue. However, she required a 30% dose reduction of interferon in December 2011 for increased pain and neutropenia. She completed her last
A Patient With Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer With Development of Leptomeningeal Carcinomatosis While on Targeted Treatment With Crizotinib
Jonathan W. Riess, Seema Nagpal, Joel W. Neal, and Heather A. Wakelee
. The patient was then treated with erlotinib for 2 cycles but developed rapid disease progression. The patient was then placed briefly on docetaxel, but mucositis and neutropenia were dose-limiting. Anaplastic lymphoma kinase (ALK) fluorescence in situ
Delivery of Adjuvant Oxaliplatin for Colon Cancer: Insights From Routine Clinical Practice
Natasha Satkunam, Xuejiao Wei, James J. Biagi, Sulaiman Nanji, and Christopher M. Booth
Javaheri KR Yin Y Gill S . Neutropenia and relative dose intensity on adjuvant FOLFOX chemotherapy are not associated with survival for resected colon cancer . J Gastrointest Cancer 2014 ; 45 : 460 – 465 . 19. Sanoff HK Carpenter WR Freburger
Trends in the Incidence and Outcomes of Hospitalized Cancer Patients With Clostridium difficile Infection: A Nationwide Analysis
Arjun Gupta, Raseen Tariq, Ryan D. Frank, Gary W. Jean, Muhammad S. Beg, Darrell S. Pardi, David H. Johnson, and Sahil Khanna
and its side effects, such as neutropenia; and infection leading to antibiotic exposure. 4 , 8 Additionally, graft-versus-host disease (GVHD) has been associated with CDI. 10 – 12 A study using the National Inpatient Sample from 2005 to 2011 reported
On the Effect of Triplet or Doublet Chemotherapy in Advanced Gastric Cancer: Results From a National Cancer Registry
Alberto Carmona-Bayonas, Paula Jiménez-Fonseca, Maria Luisa Sánchez Lorenzo, Avinash Ramchandani, Elena Asensio Martínez, Ana Custodio, Marcelo Garrido, Isabel Echavarría, Juana María Cano, Jose Enrique Lorenzo Barreto, Teresa García García, Felipe Álvarez Manceñido, Alejandra Lacalle, Marta Ferrer Cardona, Monserrat Mangas, Laura Visa, Elvira Buxó, Aitor Azkarate, Asunción Díaz-Serrano, Ana Fernández Montes, and Fernando Rivera
overall and grade 3/4 toxicities in comparison with doublets ( Table 3 ), particularly with more grade 3/4 anemia, stomatitis, febrile neutropenia (10.4% vs 6.5%), hepatic toxicity (15.8% vs 9.2%), and toxicity-related hospitalization (30.7% vs 22
Cotreatment of Hairy Cell Leukemia and Melanoma With the BRAF Inhibitor Dabrafenib
James S. Blachly, Gerard Lozanski, David M. Lucas, Michael R. Grever, Kari Kendra, and Leslie A. Andritsos
/kg/d via a 7-day continuous infusion and experienced a hematologic CR. This remission was more durable, but the patient experienced a relapse again almost 5 years later, with neutropenia and thrombocytopenia. He then received 12 doses of pentostatin, 4 mg
