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Role of Immunotherapy in Triple-Negative Breast Cancer

Tanya E. Keenan and Sara M. Tolaney

cells to mount an antitumor immune response, 16 which can be strengthened by ICIs. 17 This review presents a framework for understanding the current clinical experience surrounding ICIs and other novel immunotherapy agents in TNBC ( Figure 1 ). In

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Pharmacotherapy for Chronic Myelogenous Leukemia: A Case-Based Approach

Stephen Harnicar

comprises chronic, accelerated, and blastic phases. Breakthroughs in therapy for this disease are ongoing, and 3 targeted therapies are currently available for CML. This article provides a case-based review of the current therapy for CML from a

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Massachusetts General Hospital: Improving Patient Access to the Breast Oncology Clinic

Inga T. Lennes, Mara Bloom, Nie Bohlen, and Beverly Moy

In June 2011, the staff of the NCCN Opportunities for Improvement (OFI) project reviewed Massachusetts General Hospital’s (MGH) concordance with breast cancer quality measures. This review revealed that a small proportion of patients with breast

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Germline and Somatic Mutations in Prostate Cancer for the Clinician

Heather H. Cheng, Alexandra O. Sokolova, Edward M. Schaeffer, Eric J. Small, and Celestia S. Higano

-to-consumer “recreational” testing for understanding genealogic origins from an individual’s DNA. Tests for primary prostate cancer to determine risk of recurrence and inform decisions regarding active surveillance are addressed elsewhere. 1 – 3 This review focuses on

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Complexities of Next-Generation Sequencing in Solid Tumors: Case Studies

Alexandra O. Sokolova, Brian H. Shirts, Eric Q. Konnick, Ginger J. Tsai, Bernardo H.L. Goulart, Bruce Montgomery, Colin C. Pritchard, Evan Y. Yu, and Heather H. Cheng

in the metastatic bone biopsy ( Figure 1 ). However, this was not observed. Careful review of the variant allelic fractions from the 3 studies together showed that they were consistent with a clonal hematopoietic (CH) process being the likely source

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Factors Affecting Genetic Consultation in Adolescent and Young Adult Patients With Sarcoma

Grace E. McKay, Anna L. Zakas, Fauzia Osman, and Amanda Parkes

classic LFS criteria 12 or Chompret criteria. 13 , 14 Beyond LFS-specific guidelines, the NCCN Guidelines for Soft Tissue Sarcoma review the increased incidence of sarcoma seen in patients with LFS, hereditary nonpolyposis colorectal cancer

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Emerging Multimodality Approaches to Treat Localized Esophageal Cancer

Ronan J. Kelly

. This review discusses some of the emerging multimodality treatment approaches for esophageal and GEJ carcinomas. Although there is currently a paucity of published data, this article highlights key trials investigating checkpoint inhibitors in operable

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Studying Cancer-Related Fatigue: Report of the NCCN Scientific Research Committee

Joanne E. Mortimer, Andrea M. Barsevick, Charles L. Bennett, Ann M. Berger, Charles Cleeland, Shannon R. DeVader, Carmen Escalante, Jeffrey Gilreath, Arti Hurria, Tito R. Mendoza, and Hope S. Rugo

T he NCCN Cancer-Related Fatigue (CRF) Scientific Research Committee was convened in September 2009 to accomplish 3 objectives: 1) review the current methods to measure and interventions to treat CRF; 2) recommend a CRF measure or develop a new

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Using the Science of Psychosocial Care to Implement the New American College of Surgeons Commission on Cancer Distress Screening Standard

Lynne I. Wagner, David Spiegel, and Timothy Pearman

-accredited programs provide care to nearly 70% of patients with newly diagnosed cancer. CoC accreditation standards are reviewed every 5 to 7 years, with the addition of new standards to continually improve quality monitoring. In 2011, the ACoS CoC approved new

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Documentation of Fertility Preservation Discussions for Young Adults With Cancer: Examining Compliance With Treatment Guidelines

John M. Salsman, Betina Yanez, Kristin N. Smith, Jennifer L. Beaumont, Mallory A. Snyder, Khouri Barnes, and Marla L. Clayman

be initiated by RHLCCC's female oncologists or when patients are diagnosed at a younger age. Methods Patients and Procedures This work was conducted in compliance with the Scientific Review Committee of the RHLCCC and the Northwestern