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Breast Cancer Screening and Diagnosis Clinical Practice Guidelines

The University of Alabama at Birmingham Comprehensive Cancer Center

The lifetime risk of a woman developing breast cancer has increased over the past 5 years in the United States: of every 7 women, 1 is at risk based on a life expectancy of 85 years. An estimated 214,640 new cases (212,920 women and 1,720 men) of breast cancer and 41,430 deaths (40,970 women and 460 men) from this disease will occur in the United States in 2006. However, mortality from breast cancer has decreased slightly, attributed partly to mammographic screening. Early detection and accurate diagnosis made in a cost-effective manner are critical to a continued reduction in mortality. These practice guidelines are designed to facilitate clinical decision making.

For the most recent version of the guidelines, please visit NCCN.org

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Multidisciplinary Management of Locally Advanced Rectal Cancer: Neoadjuvant Approaches

Swaminathan Murugappan, William P. Harris, Christopher G. Willett, and Edward Lin

Rectal cancer constitutes one-quarter of colorectal cancer cases and is the third most common gastrointestinal tract cancer, with approximately 40,000 cases diagnosed in the United States annually. 1 Although the survival of patients with rectal

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Delays in Care Associated With Non–English-Speaking Patients With Breast Cancer

Katy E. Balazy, Cecil M. Benitez, Paulina M. Gutkin, Clare E. Jacobson, Rie von Eyben, and Kathleen C. Horst

Background Breast cancer is the second leading cause of cancer death for women in the United States, with an estimated 276,480 new diagnoses and 42,170 breast cancer–related deaths in 2020. 1 Despite mortality declining by 40% between 1989 and

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Renal Cell Cancer: A Shift in Approaches for Treatment of Advanced Disease in the United States

Matthew P. Banegas, Linda C. Harlan, Bhupinder Mann, and K. Robin Yabroff

In 2013, approximately 65,150 individuals in the United States were diagnosed with renal cell cancer (RCC). 1 Most (>60%) will have localized disease at diagnosis, although recurrences will develop in approximately 40% of patients initially

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Erythropoiesis-Stimulating Agents in Oncology

John A. Glaspy

Dr. Glaspy has received research support from Amgen Inc., Ortho Biotech, L.P., and Roche. References 1. Bohlius J Wilson J Seidenfeld J . Erythropoietin or darbepoetin for patients with cancer . Cochrane Database Syst Rev

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Is Advanced Imaging in Early-Stage Breast Cancer Ever Warranted? Reconciling Clinical Judgment With Common Quality Measures

Arif Kamal, Tian Zhang, Steve Power, and P. Kelly Marcom

services in early-stage breast cancer (ESBC), stating, “Don't perform PET, CT, and radionuclide bone scans in the staging of early breast cancer at low risk for metastasis.” 1 For these recommendations, the Choosing Wisely initiative defines early

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Genetic/Familial High-Risk Assessment: Breast and Ovarian

Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher, and Jeffrey N. Weitzel

Overview All cancers develop as a result of mutations in certain genes, such as those involved in the regulation of cell growth and/or DNA repair, 1 , 2 but not all of these mutations are inherited from a parent. For example, sporadic

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Preoperative and Postoperative Approaches to Gastroesophageal Cancer: What is All the Fuss About

Lucy X. Ma, Elan D. Panov, Michael J. Allen, Gail E. Darling, Jonathan C. Yeung, Carol J. Swallow, Savtaj S. Brar, Rebecca K. Wong, Patrick Veit-Haibach, Sangeetha N. Kalimuthu, Eric X. Chen, Raymond W. Jang, and Elena Elimova

Gastroesophageal cancers are a heterogeneous group of cancers that develop insidiously and carry poor prognoses. 1 , 2 Worldwide, gastric adenocarcinoma and esophageal cancer represent the fourth and sixth most common causes of cancer

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Gastric and Esophageal Cancers: Guidelines Updates

Presented by: Crystal S. Denlinger, Kristina A. Matkowskyj, and Mary F. Mulcahy

For the treatment of gastric and esophageal cancers, recent studies have demonstrated robust findings for new drugs that, as a consequence, are becoming FDA-approved and added to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines

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Optimizing the Quality of Breast Cancer Biomarker Use at Duke Cancer Institute

Arif H. Kamal, Steve Power, Gloria Broadwater, Audrey R. Holland, and Paul K. Marcom

In 2012, more than 200,000 women in the United States were diagnosed with invasive breast cancer. Despite the high incidence, 5-year curative rates for early-stage cancer exceed 85%, reflecting remarkable progress over the past 3 decades in