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radiation); 24 (32.9%) patients had received prior chemotherapy before the initiation of PD-1 blockade. Table 1. Baseline Characteristics Response to PD-1 Blockade Response data are shown in Table 2 . Of the 73 patients, 62 (84.9%) achieved

molecular biology and genomic profiling have led to the identification of several genetic aberrations and tumor characteristics that allow for distinct subgroups of metastatic CRC (mCRC) with both prognostic and predictive implications. One of these

first evidence of treatment ≥4 months from their advanced diagnosis date. Patient attrition is shown in supplemental eTable 1 (available with this article at JNCCN.org ). Construction of Variables Clinical characteristics included demographics

. Research staff collected information about cancer diagnosis, oral therapy type, and other clinical characteristics from the EHR. Electronic Adherence Monitoring Participants were asked to store their oral therapy medication in pill bottles with electronic

from index date), and provider-confirmed mCRC status via requisition form on the date of the G360 test. Outcomes Assessed Patient characteristics collected at index date were age, sex, year of index, geographic location (state), payer type

account for differences in the distribution of baseline characteristics between treatment groups, a propensity score method was used to reduce the effect of potential confounding. 12 , 13 First, the inverse probability of treatment weighting (IPTW) using

with patient characteristics, these profiles ensure that targeted therapies are selectively applied in delivering patient-centered care. A shining example of this has been the incorporation of trastuzumab for cancers that overexpress HER2, the use of

, potential eligible patients were first identified through the DCRA, and collaborators in each participating hospital were provided with their own patients registered in the DCRA. Subsequently, collaborators extended baseline characteristics and short

blood pressure ≥90 mm Hg, or claims for antihypertensive medications under ICD-10-CM codes I10–I13 and I15. Statistical Analysis According to smoking status, baseline characteristics were compared using the chi-test for categorical variables and

rectal cancers will be diagnosed in individuals aged <50 years. 3 , 5 Individuals with EOCRC present with different clinical, pathologic, and molecular characteristics compared with average age–onset CRC. Studies have shown that patients with EOCRC are