M ore than 21,000 women are estimated to be diagnosed with epithelial ovarian cancer in the United States in 2010, and an estimated 13,850 will die of the disease. 1 Of all gynecologic cancers, ovarian cancer is the most common cause of death. 1
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Indications for Minimally Invasive Surgery for Ovarian Cancer
Ernest S. Han and Mark Wakabayashi
Cancer- and Chemotherapy-Induced Anemia
The University of Alabama at Birmingham Comprehensive Cancer Center
Anemia is a common condition in patients with cancer, and its correction through either transfusion with packed red blood cells or the administration of erythropoiesis-stimulating agents (ESAs) is a supportive care measure. The purpose of the guidelines is to operationalize the evaluation and treatment of anemia in cancer patients and to enable patients and clinicians to evaluate treatment options in the context of risks and benefits. The updated guidelines include a number of important changes that respond to new FDA recommendations limiting the use of ESAs in cancer patients. Updates also include new tables on the risks and benefits of ESAs versus red blood cell transfusion and recommendations for administering parenteral iron products.
For the most recent version of the guidelines, please visit NCCN.org
New Developments in the Treatment of Castration-Resistant Prostate Cancer
Celestia S. Higano
Understanding clinical disease states in castration-resistant prostate cancer (CRPC) is important to making intelligent choices for therapy for patients, said Celestia S. Higano, MD, Professor, Departments of Medicine and Urology, University of
Medullary Carcinoma
R. Michael Tuttle, Douglas W. Ball, David Byrd, Gilbert H. Daniels, Raza A. Dilawari, Gerard M. Doherty, Quan-Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith McCaffrey, John A. Olson Jr., Lee Parks, John A. Ridge, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, and Lori J. Wirth
exposure to head and neck irradiation. 12 , 13 NCCN Clinical Practice Guidelines in Oncology : Medullary Carcinoma Version 1.2010, 01-14-10 ©2010 National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration
Adjuvant Chemotherapy Decisions in Clinical Practice for Early-Stage Node-Negative, Estrogen Receptor-Positive, HER2-Negative Breast Cancer: Challenges and Considerations
Gayathri Nagaraj and Cynthia X. Ma
NCCN: Continuing Education Accreditation Statement This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer. There is no fee for this article. No commercial
Update on the Sentinel Node Procedure in Vulvar Cancer
Willemijn L. van der Kolk, Joost Bart, Ate J.G. van der Zee, and Maaike H.M. Oonk
Vulvar Cancer: An Introduction Vulvar cancer represents 3% of all gynecologic cancers, affecting 2.4 per 100,000 women on average in Western Europe in 2020. 1 The most common type, vulvar squamous cell carcinoma (VSCC), accounts for 90% of
Neoadjuvant Immunotherapy–Based Systemic Treatment in MMR-Deficient or MSI-High Rectal Cancer: Case Series
Rahel Demisse, Neha Damle, Edward Kim, Jun Gong, Marwan Fakih, Cathy Eng, Leslie Oesterich, Madison McKenny, Jingran Ji, James Liu, Ryan Louie, Kit Tam, Sepideh Gholami, Wissam Halabi, Arta Monjazeb, Farshid Dayyani, and May Cho
In 2020, 43,340 new cases of rectal cancer were diagnosed, most of which were localized or locoregional disease. 1 It is estimated that 10% to 15% of all sporadic colorectal cancer (CRC) cases are mismatch repair–deficient (dMMR) or microsatellite
Uterine Cancers Clinical Practice Guidelines
The University of Alabama at Birmingham Comprehensive Cancer Center
Adenocarcinoma of the endometrium is the most common malignancy of the female genital tract in the United States. Many physicians believe that adenocarcinoma of the endometrium is a relatively benign disease because of the early symptoms of irregular vaginal bleeding in this predominantly postmenopausal patient population, the often-localized nature of the disease, and the generally high survival rate. However, the estimated number of deaths from endometrial cancer continues to increase, indicating the need for a critical reassessment of the guidelines for managing endometrial cancer. Physicians must identify high-risk patients and tailor treatment appropriately to provide the best opportunity for long-term survival.
For the most recent version of the guidelines, please visit NCCN.org
Engaging Community-Based Cancer Physicians: Experience of the Memorial Sloan Kettering Cancer Center Cancer Alliance
Allison Lipitz-Snyderman, Jessica Kennington, Brooke Hogan, Deborah Korenstein, Leonard Kalman, Suresh Nair, Peter Yu, Paul Sabbatini, and David Pfister
evident than in oncology, where community health systems have begun to partner with academic medical centers, which are attempting to extend their reach into the community setting, where 85% of cancer care is delivered. 6 , 7 Several NCI
Gene Panel Testing for Inherited Cancer Risk
Michael J. Hall, Andrea D. Forman, Robert Pilarski, Georgia Wiesner, and Veda N. Giri
can be performed in the context of assessing for mutations in the germline related to inherited cancer risk, or testing for genetic mutations in a solid tumor or leukemia/lymphoma to gain insights into somatic mutations involved in carcinogenesis and