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George D. Demetri, Scott Antonia, Robert S. Benjamin, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad III, Thomas F. DeLaney, Kristen N. Ganjoo, Martin J. Heslin, Raymond J. Hutchinson, John M. Kane III, G. Douglas Letson, Sean V. McGarry, Richard J. O'Donnell, I. Benjamin Paz, John D. Pfeifer, Raphael E. Pollock, R. Lor Randall, Richard F. Riedel, Karen D. Schupak, Herbert S. Schwartz, Katherine Thornton, Margaret von Mehren, and Jeffrey Wayne

and contiguity to nearby visceral structures and neurovascular landmarks. The propensities to spread to various locations vary among the subtypes of sarcoma. Therefore, imaging should be individualized based on the subtype of sarcoma. MRI with or

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Keli Turner, Sheelu Varghese, and H. Richard Alexander

CT scans and tissue biopsy with appropriate immunohistochemical staining. Although CT scan is the diagnostic imaging most commonly used, MRI using specific acquisition protocols may be increasingly used in the future. 20 The role of PET or PET/CT is

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Ali Mokdad, Travis Browning, John C. Mansour, Hao Zhu, Amit G. Singal, and Adam C. Yopp

on characteristic radiographic imaging on dynamic contrasted-enhanced CT or MRI. Most of these diagnostic imaging studies are ordered by primary care physicians, who are at the beginning of the cancer care continuum and must not only discern an

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Matthias Holdhoff, Maciej M. Mrugala, Christian Grommes, Thomas J. Kaley, Lode J. Swinnen, Carlos Perez-Heydrich, and Lakshmi Nayak

diagnosis of PCNSL requires comprehensive workup and staging. In addition to imaging of the brain and entire spine using MRI with contrast, cerebrospinal fluid analysis (CSF) and ophthalmologic examination to rule out ocular involvement are necessary. Brain

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Donald A. Podoloff, Douglas W. Ball, Edgar Ben-Josef, Al B. Benson III, Steven J. Cohen, R. Edward Coleman, Dominique Delbeke, Maria Ho, David H. Ilson, Gregory P. Kalemkerian, Richard J. Lee, Jay S. Loeffler, Homer A. Macapinlac, Robert J. Morgan Jr., Barry Alan Siegel, Seema Singhal, Douglas S. Tyler, and Richard J. Wong

Franz M . Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy . Int J Radiat Oncol Biol Phys 2005 ; 63 : 511 – 519 . 49

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William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

: Breast and Ovarian (to view the most recent version of these guidelines, visit NCCN.org ). Use of MRI during initial workup is optional and may be specially considered for mammographically occult tumors. MRI may be used to define the extent of cancer

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Louis Burt Nabors

-year-old man with a remote history of concussion experienced a new-onset partial seizure. Workup included a normal neurologic examination, and results of an MRI revealed glioma. Surgery was performed and a very clean resection was achieved. Based on

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Kenneth C. Anderson

studies, the International Myeloma Working Group (IMWG) has determined that patients with more than 60% bone marrow plasmacytosis, more than 100-fold free light chain ratio, or more than one bone lesion on PET/CT or MRI scanning, even in the absence of

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David Chu and Douglas G. Adler

diagnostic modalities include transabdominal ultrasound, helical CT, and MRI/magnetic resonance cholangiopancreatography (MRCP). Additional modalities that are both diagnostic and allow for therapeutic interventions include endoscopic ultrasound (EUS

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Shaji K. Kumar

on hypercalcemia, renal insufficiency, anemia, and bone disease (CRAB), whereas the expanded definition now includes bone marrow plasma cell involvement ≥60%, >1 lesion on PET/MRI, and free light chain ratio ≥100, in addition to CRAB. The new