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Christopher Loiselle and Wui-Jin Koh

alter the arrangement of surrounding normal tissues. Tumor regression during treatment is a fortunate, though complex, reality and renders target definition based on a single preradiation CT scan less dependable. Serial MRI has been used to

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Matthias Holdhoff, Maciej M. Mrugala, Christian Grommes, Thomas J. Kaley, Lode J. Swinnen, Carlos Perez-Heydrich, and Lakshmi Nayak

diagnosis of PCNSL requires comprehensive workup and staging. In addition to imaging of the brain and entire spine using MRI with contrast, cerebrospinal fluid analysis (CSF) and ophthalmologic examination to rule out ocular involvement are necessary. Brain

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Donald A. Podoloff, Douglas W. Ball, Edgar Ben-Josef, Al B. Benson III, Steven J. Cohen, R. Edward Coleman, Dominique Delbeke, Maria Ho, David H. Ilson, Gregory P. Kalemkerian, Richard J. Lee, Jay S. Loeffler, Homer A. Macapinlac, Robert J. Morgan Jr., Barry Alan Siegel, Seema Singhal, Douglas S. Tyler, and Richard J. Wong

Franz M . Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy . Int J Radiat Oncol Biol Phys 2005 ; 63 : 511 – 519 . 49

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Mokenge P. Malafa

to be complementary to CT or MRI, providing additional information for patients whose initial scans show no lesion or whose lesions have questionable involvement of the vasculature or lymph nodes. However, the panel agreed that although the EUS has a

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Shaji K. Kumar

on hypercalcemia, renal insufficiency, anemia, and bone disease (CRAB), whereas the expanded definition now includes bone marrow plasma cell involvement ≥60%, >1 lesion on PET/MRI, and free light chain ratio ≥100, in addition to CRAB. The new

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Andrea K. Ng and Lois B. Travis

with HL who undergo radiotherapy in the modern treatment era will probably incur a lower risk for breast cancer. For survivors of HL, NCCN recommends mammogram/breast MRI screening 8 to 10 years after irradiation or by 40 years of age. The American

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J. Sybil Biermann, Douglas R. Adkins, Robert S. Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad III, Deborah A. Frassica, Frank J. Frassica, Suzanne George, Kenneth R. Hande, Francis J. Hornicek, G. Douglas Letson, Joel Mayerson, Sean V. McGarry, Brian McGrath, Carol D. Morris, Richard J. O'Donnell, R. Lor Randall, Victor M. Santana, Robert L. Satcher, Herrick J. Siegel, Neeta Somaiah, and Alan W. Yasko

. Standard staging workup for a suspected primary bone sarcoma should include chest imaging (chest radiograph or CT to detect pulmonary metastases), appropriate imaging of the primary site (plain radiographs, MRI for local staging, and/or CT scan), and bone

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Talha Mehmood and Thomas J. Smith

place, patients will end up in the emergency department and be admitted. For oncologists, the message is, “don't save the tough conversations until the last hospitalization.” Rather, progression of disease on CT or MRI scans should trigger the question

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Kenneth C. Anderson

studies, the International Myeloma Working Group (IMWG) has determined that patients with more than 60% bone marrow plasmacytosis, more than 100-fold free light chain ratio, or more than one bone lesion on PET/CT or MRI scanning, even in the absence of

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David P. Steensma

not predict poor outcomes in a Mayo Clinic series of 88 patients with del(5q) MDS. 18 In addition, several recent studies have used MRI to assess cardiac iron accumulation in transfused patients with MDS, using the T2 * (R2 * ) gradient echo technique