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Clayton A. Smith and Lisa A. Kachnic

, historical rates of local failure following surgery alone using older techniques were ≥25%. 2 The development of total mesorectal excision (TME) with sharp dissection of mesorectal contents further reduced the rates of local recurrence to as low as 8%. 3

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NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021

Featured Updates to the NCCN Guidelines

Susan M. Swetter, John A. Thompson, Mark R. Albertini, Christopher A. Barker, Joel Baumgartner, Genevieve Boland, Bartosz Chmielowski, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossmann, Samantha Guild, Ashley Holder, Douglas Johnson, Richard W. Joseph, Giorgos Karakousis, Kari Kendra, Julie R. Lange, Ryan Lanning, Kim Margolin, Anthony J. Olszanski, Patrick A. Ott, Merrick I. Ross, April K. Salama, Rohit Sharma, Joseph Skitzki, Jeffrey Sosman, Evan Wuthrick, Nicole R. McMillian, and Anita M. Engh

constrained sites (eg, face, palms, soles), in addition to the presence of atypical/actinic melanocytic hyperplasia in the LM subtype (high-CSD melanoma) which often confounds histologic assessment of margin status. 88 , 105 – 117 For this reason, surgery

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Neha Mehta-Shah and Paola Ghione

, and can be cured with surgery alone in the vast majority of cases. Moreover, it seems to be preventable by avoiding placement of textured breast implants—the apparent causative device. BIA-ALCL was first described in 1997 and recognized as a

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William C. Huang and Bernard H. Bochner

Herr H . Outcome of postchemotherapy surgery after treatment with methotrexate, vinblastine, doxorubicin, and cisplatin in patients with unresectable or metastatic transitional cell carcinoma . J Clin Oncol 1999 ; 17 : 2546 – 2552 . 50

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Fikri İçli, Hakan Akbulut, Shouki Bazarbashi, Mehmet Ayhan Kuzu, Mohandas K. Mallath, Kakil Ibrahim Rasul, Scott Strong, Aamir Ali Syed, Faruk Zorlu, and Paul F. Engstrom

in accordance with the NCCN Guidelines, except those related to questions number 1 and 10. According to the results, 69% did not perform routine chest CT before surgery for all patients with colon cancer. With regard to first-line chemotherapy for

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Nisar Ahmad, Denise M. Adams, Jiang Wang, Rajan Prakash, and Nagla Abdel Karim

patient was referred for a liver transplant but was deemed inappropriate for transplant secondary to peritoneal studding, and frozen section analysis showed metastatic disease at the time of surgery. Case Presentation A 24-year-old woman with no

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Jaffer A. Ajani

Bray F Ferlay J Pisani P . Global cancer statistics, 2002 . CA Cancer J Clin 2005 ; 55 : 74 – 108 . 4. Macdonald JS Smalley SR Benedetti J . Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or

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William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

Approach Conceptually, the treatment of breast cancer includes the treatment of local disease with surgery, radiation therapy, or both, and the treatment of systemic disease with cytotoxic chemotherapy, endocrine therapy, biologic therapy, or combinations

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Al B. Benson III, Alan P. Venook, Mahmoud M. Al-Hawary, Mustafa A. Arain, Yi-Jen Chen, Kristen K. Ciombor, Stacey A. Cohen, Harry S. Cooper, Dustin A. Deming, Ignacio Garrido-Laguna, Jean L. Grem, Sarah E. Hoffe, Joleen Hubbard, Steven Hunt, Ahmed Kamel, Natalie Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Jeffrey Meyerhardt, Eric D. Miller, Mary F. Mulcahy, Steven Nurkin, Michael J. Overman, Aparna Parikh, Hitendra Patel, Katrina S. Pedersen, Leonard B. Saltz, Charles Schneider, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Elena M. Stoffel, Eden Stotsky-Himelfarb, Christopher G. Willett, Alyse Johnson-Chilla, Kristina M. Gregory, and Lisa A. Gurski

associated with a lower ratio of positive-to-negative lymph nodes as well as with a higher number of regional lymph nodes assessed during surgery. 38 , 58 – 60 Two of these analyses, which considered duodenal and jejunoileal adenocarcinomas separately

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Yan Si, Jingsheng Cai, Hao Zhang, Haisheng Fang, and Meiping Shen

patients who receive initial thyroid surgery in our center, describe the structural features of TTL, and investigate the positional relationship of TTL and IPTG. Results: TTL is a kind of adipose connective tissue that is wide at the bottom and narrow at