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Neoadjuvant Chemotherapy First, Followed by Chemoradiation and Then Surgery, in the Management of Locally Advanced Rectal Cancer

Andrea Cercek, Karyn A. Goodman, Carla Hajj, Emily Weisberger, Neil H. Segal, Diane L. Reidy-Lagunes, Zsofia K. Stadler, Abraham J. Wu, Martin R. Weiser, Philip B. Paty, Jose G. Guillem, Garrett M. Nash, Larissa K. Temple, Julio Garcia-Aguilar, and Leonard B. Saltz

) The most common grade 1/2 toxicities with FOLFOX were fatigue (58%), nausea (32%), and neutropenia (25%). The most common grade 3 toxicities were diarrhea (4%), fatigue (1%), nausea (1%), and neutropenia (1%). These were managed with dose reductions

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A Review of the Symptomatic Management of Malignant Gliomas in Adults

Umang Shah and Tara Morrison

delayed effects of treatment can help physicians and patients make informed choices bearing on survival and QOL. Several studies in patients with malignant gliomas showed that fatigue is the most frequently reported and troublesome of all symptoms. It is

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Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma

Aatur D. Singhi, Siraj M. Ali, Jill Lacy, Andrew Hendifar, Khanh Nguyen, Jamie Koo, Jon H. Chung, Joel Greenbowe, Jeffrey S. Ross, Marina N. Nikiforova, Herbert J. Zeh, Inderpal S. Sarkaria, Anil Dasyam, and Nathan Bahary

carcinoma ( Figure 1D–F ). However, among the 4 tubular-type PDACs, 1 showed prominent extracellular mucin. Clinical presentation, treatment, and follow-up information was available for 4 of 5 patients. Case 1 A 35-year-old man presented with fatigue

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Using the Science of Psychosocial Care to Implement the New American College of Surgeons Commission on Cancer Distress Screening Standard

Lynne I. Wagner, David Spiegel, and Timothy Pearman

per symptom, computer-scored, and bench-marked based on normative data from thousands of patients. Assessment consists of PROMIS CAT item banks to measure anxiety, depression, fatigue, pain, and physical function, administered through Assessment Center

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Evaluation of Scores to Reflect Toxicity Impact on Quality of Life of Patients With Platinum-Resistant Ovarian Cancer: AURELIA Substudy

Justine Lequesne, Florence Joly, Julien Peron, Isabelle Ray-Coquard, Anne-Claire Hardy-Bessard, Frédéric Selle, Dominique Berton, Philippe Follana, Michel Fabbro, Alain Lortholary, Eric Pujade-Lauraine, Sophie Lefèvre-Arbogast, and Elodie Coquan

scales (fatigue, pain, and nausea/vomiting), 6 single items (appetite loss, constipation, diarrhea, dyspnea, insomnia, and financial difficulties), and a global health status. Questionnaires were collected at baseline and every 2 cycles (or 3 cycles for

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Patient-Defined Goals and Preferences Among Adults With Advanced Neuroendocrine Tumors

Daneng Li, Can-Lan Sun, Heeyoung Kim, Christiana Crook, Ya-Han Zhang, Rebecca Allen, Richard Ballena, Shadman Hyder, Marianna Koczywas, Vincent Chung, Dean Lim, Vani Katheria, William Dale, and Gagandeep Singh

eliminating dizziness, fatigue, and/or shortness of breath as their most important health outcome on the Health Outcomes Tool, 46.7% (95% CI, 34.0%–59.3%) of patients chose maintaining independence as their most important health outcome ( Table 2 ). Only 30

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Prevalence of Breast Cancer Survivors Among Canadian Women

Amy A. Kirkham and Katarzyna J. Jerzak

mobility, sensory disorders) persists in up to half of BCS 2 years after diagnosis. 40 Cancer-related fatigue persists in one-third of BCS at 5 to 10 years after diagnosis. 41 Cancer-related cognitive impairment has been noted on cognitive tests and

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New Agents in Metastatic Prostate Cancer

Atish D. Choudhury and Philip W. Kantoff

incidences of all grades of fatigue (34% vs. 29%), diarrhea (21% vs. 18%), hot flashes (20% vs. 10%), musculoskeletal pain (14% vs. 10%), and headache (12% vs. 6%) were seen with enzalutamide (statistical significance for these events was not reported). Also

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Survivorship: Introduction and Definition

Crystal S. Denlinger, Robert W. Carlson, Madhuri Are, K. Scott Baker, Elizabeth Davis, Stephen B. Edge, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Elizabeth Kvale, Terry S. Langbaum, Jennifer A. Ligibel, Mary S. McCabe, Kevin T. McVary, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Tracey O’Connor, Electra D. Paskett, Muhammad Raza, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole McMillian, and Deborah Freedman-Cass

Guidelines for Survivorship, the panel focused on 8 common issues of survivors: 1) anxiety and depression, 2) cognitive decline, 3) pain, 4) female and male sexual dysfunction, 5) immunizations and prevention of infections, 6) fatigue, 7) sleep disorders, and

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Priority Rankings of Patient-Reported Outcomes for Pancreatic Ductal Adenocarcinoma: A Comparison of Patient and Physician Perspectives

Michelle Guan, Gillian Gresham, Arvind Shinde, Isaac Lapite, Jun Gong, Veronica R. Placencio-Hickok, Christopher B. Forrest, and Andrew E. Hendifar

fatigue, and overall greater burden than patients with other cancer types. 16 , 17 Despite the distinct burdens of patients with PDAC, it is still poorly understood which domains of the PROMIS item banks are prioritized by these patients. After a 2016