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Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology

James L. Mohler, Emmanuel S. Antonarakis, Andrew J. Armstrong, Anthony V. D’Amico, Brian J. Davis, Tanya Dorff, James A. Eastham, Charles A. Enke, Thomas A. Farrington, Celestia S. Higano, Eric Mark Horwitz, Michael Hurwitz, Joseph E. Ippolito, Christopher J. Kane, Michael R. Kuettel, Joshua M. Lang, Jesse McKenney, George Netto, David F. Penson, Elizabeth R. Plimack, Julio M. Pow-Sang, Thomas J. Pugh, Sylvia Richey, Mack Roach III, Stan Rosenfeld, Edward Schaeffer, Ahmad Shabsigh, Eric J. Small, Daniel E. Spratt, Sandy Srinivas, Jonathan Tward, Dorothy A. Shead, and Deborah A. Freedman-Cass

Overview An estimated 174,650 new cases of prostate cancer will be diagnosed in 2019, accounting for 20% of new cancer cases in men. 1 The age-adjusted death rates from prostate cancer have declined 51% from 1993 to 2016. 1 Researchers have

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Exocrine Pancreas Cancer and Thromboembolic Events: A Systematic Literature Review

Andrew S. Epstein and Eileen M. O'Reilly

the joint sponsorship of Medscape, LLC and JNCCN – The Journal of the National Comprehensive Cancer Network . Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians. Medscape, LLC designates this Journal

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Analysis of Circulating Tumor Cells in Breast Cancer

Zeynep Eroglu, Odicie Fielder, and George Somlo

Through coordinated scientific, medical, and public health advances, 5-year survival rates for breast cancer approach 90%. However, microscopic residual disease frequently results in local relapse or metastasis, leading to approximately 40

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Sessile Serrated Polyps: An Important Route to Colorectal Cancer

Matthew F. Kalady

initial lesion in the serrated pathway to cancer. HPs are the most common serrated polyp and are commonly located in the distal colon and rectum. Longacre and Fenoglio-Preiser 3 first recognized a subset of hyperplastic polyps with dysplasia as a

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Next-Generation Cancer Vaccine Approaches: Integrating Lessons Learned From Current Successes With Promising Biotechnologic Advances

Dung T. Le and Elizabeth M. Jaffee

patients with advanced melanoma treated with gp100 peptide vaccine plus high-dose interleukin 2 (IL-2) over those treated with IL-2 alone. 12 Importantly, the success of sipuleucel-T for prostate cancer and the predicted success of agents that block the PD

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QIM19-117: Reducing Diagnostic Delays: Impact of a Novel Cancer Diagnostic Service

Luke Arney, Ryan Leib, Louise Schneider, Cori Kostick, Kerry Kilbridge, Ramin Khorasani, Oreofe Odejide, and Lindsay C. Carter

Background: Although timeliness of care was one of the aims of quality improvement in the Institute of Medicine’s 2001 “Crossing the Quality Chasm” report, a significant proportion of patients with cancer still experience delays in diagnosis and

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Modern Approaches to Localized Cancer of the Esophagus

Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy, and Jaffer A. Ajani

E sophageal cancer is a highly lethal disease, with approximately 16,640 new cases diagnosed and 14,500 related deaths each year in the United States. 1 Despite recent decreases in the overall incidence of cancer and cancer-related deaths in the

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Adult Cancer Pain

Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Pain is one of the most common symptoms associated with cancer and one of the symptoms patients fear most; unrelieved pain denies them comfort and greatly affects their activities, motivation, interactions with family and friends, and overall quality of life. The importance of relieving pain and availability of effective therapies make it imperative that clinicians caring for cancer patients to be adept at assessing and treating cancer pain. The National Comprehensive Cancer Network Adult Cancer Pain Clinical Practice Guidelines in Oncology acknowledge the range of complex decisions faced in caring for these patients. As a result, they provide dosing guidelines for NSAIDs, opioids, and adjuvant analgesics. They also provide specific suggestions for escalating opioid dosage, managing opioid toxicity, and when and how to proceed to other techniques to manage cancer pain.

For the most recent version of the guidelines, please visit

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Chemotherapy Hypersensitivity Reactions in Ovarian Cancer

Matthieu Picard, Ursula A. Matulonis, and Mariana Castells

Ovarian cancer is the leading cause of death among gynecologic malignancies and ranks fifth in overall cancer-related mortality among women in the United States. 1 Chemotherapy, particularly with a taxane and platinum combination, is key to

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Establishing an Anemia Clinic for Optimal Erythropoietic-Stimulating Agent Use in Hematology-Oncology Patients

Jeffrey A. Gilreath, Daniel S. Sageser, James A. Jorgenson, and George M. Rodgers

Belle S Barrett-Lee P . The European Cancer in Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients . Eur J Cancer 2004 ; 40 : 2293 – 2306 . 2