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The Aromatase Inhibitors as Adjuvant Therapy for Hormone Receptor-Positive Breast Cancer

Jennifer A. Ligibel and Eric P. Winer

References 1 Group EBTC . Tamoxifen for early breast cancer: an overview of the randomized trials . Lancet 1998 ; 351 : 1451 – 1467 . 2 Report from the Breast Cancer Trials Committee SCTO, Edinburgh . Adjuvant tamoxifen

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The STAR Trial: Evidence for Raloxifene as a Breast Cancer Risk Reduction Agent for Postmenopausal Women

Therese B. Bevers

– 5687 . 2. Lamb CA Helguero LA Fabris V . Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma . Breast Cancer Res Treat 2003 ; 79 : 25 – 35 . 3. Sporn MB Dowsett SA Mershon J Bryant HU

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Aromatase Inhibitors in Postmenopausal Breast Cancer Patients

Alyssa G. Rieber and Richard L. Theriault

carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases . Lancet 1896 ; 2 : 104 – 107 . 2 Fisher B Costantino JP Wickerham DL . Tamoxifen for prevention of breast cancer: report of the National Surgical

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NCCN Task Force Report: Adjuvant Therapy for Breast Cancer

Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force

predictive factors? Can certain subsets of premenopausal women with ER-positive tumors be adequately treated using tamoxifen and/or ovarian suppression and forego adjuvant chemotherapy? What is the optimal strategy for using aromatase inhibitors (AIs) in the

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21-Gene Recurrence Score and Survival Outcomes in the Phase III Multicenter TAILORx Clinical Trial

Sherry X. Yang, John Yu, and Molin Wang

, hazard ratio; OFS, ovarian function suppression; PR, progesterone receptor; RFI, recurrence-free interval; RS, recurrence score; Tam, tamoxifen. Figure 2. Recurrence scores and clinical factors for (A) OS and (B) DFS prognosis. Horizontal

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NCCN Task Force Report: Breast Cancer in the Older Woman

Robert W. Carlson, Susan Moench, Arti Hurria, Lodovico Balducci, Harold J. Burstein, Lori J. Goldstein, William J. Gradishar, Kevin S. Hughes, Mohammad Jahanzeb, Stuart M. Lichtman, Lawrence B. Marks, Joan S. McClure, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Mary Lou Smith, Neal S. Topham, Tiffany A. Traina, John H. Ward, and Eric P. Winer

anthracyclines or trastuzumab; 21 – 23 kidney dysfunction and capecitabine; 16 preexisting neuropathy and taxanes; 24 history of thromboembolism and tamoxifen (venous thromboembolism) or bevacizumab (arterial thromboembolism); 25 , 26 and osteoporosis and

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Barriers to the Use of Breast Cancer Risk Reduction Therapies

Arvind Bambhroliya, Mariana Chavez-MacGregor, and Abenaa M. Brewster

). BCPT randomized women to receive tamoxifen or placebo, and results showed that the tamoxifen arm had a significant reduction in the risk of developing an estrogen receptor (ER)–positive tumor (relative risk [RR], 0.38; 95% CI, 0.28–0.50), and had no

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New Persistent Opioid and Benzodiazepine Use After Curative-Intent Treatment in Patients With Breast Cancer

Mandy R. Sakamoto, Megan Eguchi, Christine M. Azelby, Jennifer R. Diamond, Christine M. Fisher, Virginia F. Borges, Cathy J. Bradley, and Peter Kabos

). Patients who received tamoxifen or with depression/anxiety were more likely to develop persistent benzodiazepine use at 3 months (OR, 1.93 [95% CI, 1.12–3.33] and 1.74 [CI, 1.01–3.01], respectively). The other subgroup consisted primarily of clonazepam and

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NCCN Guidelines Update: Breast Cancer

William Gradishar and Kilian E. Salerno

recent trial data. For premenopausal women at diagnosis, the NCCN Guidelines for Breast Cancer suggest tamoxifen for 5 years, with or without ovarian suppression, or an AI for 5 years combined with ovarian suppression or ablation (category 1). Women who

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NCCN Task Force Report: Bone Health in Cancer Care

Julie R. Gralow, J. Sybil Biermann, Azeez Farooki, Monica N. Fornier, Robert F. Gagel, Rashmi Kumar, Georgia Litsas, Rana McKay, Donald A. Podoloff, Sandy Srinivas, and Catherine H. Van Poznak

, United Kingdom: Blackwell Healthcare Communications; 1997:22–55. b Eastell R, Hannon RA, Cuzick J, et al. Effect of anastrozole on bone density and bone turnover: results of the ‘Arimidex’ (anastrozole), Tamoxifen, Alone or in Combination (ATAC) study