, 2007 . CA Cancer J Clin 2007 ; 57 : 43 – 66 . 3. Kelsen DP Ginsberg R Pajak TF . Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer . N Engl J Med 1998 ; 339 : 1979 – 1984 . 4
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Alfredo A. Santillan, Jeffrey M. Farma, Kenneth L. Meredith, Nilay R. Shah, and Scott T. Kelley
Stephen B. Edge
clinical trials. Early trials showed that extended surgery (“local therapy”) does not improve mortality over less aggressive surgery. Trials conducted in the 1970s and 1980s clearly showed that radical surgery involving removal of the breast provides no
Caijin Lin, Jiayi Wu, Shuning Ding, Chihwan Goh, Lisa Andriani, Shuangshuang Lu, Kunwei Shen, and Li Zhu
– 11 De novo MBC is considered incurable but treatable. Generally, systemic therapy is viewed as the mainstay of treatment. 12 Primary tumor surgery is considered in selected patients, mostly in the palliative setting for those with impending
Mark D. Tyson and Sam S. Chang
salvage therapies. 7 Although most recurrences present within the first couple of years after surgery and approximately half of all distant recurrences occur in the lung, late recurrences and nonpulmonary sites of metastatic disease are not uncommon. 5
Mark T. Wakabayashi, Paul S. Lin, and Amy A. Hakim
Edited by Kerrin G. Robinson
debulking surgery . J Surg Oncol 1991 ; 48 : 39 – 44 . 4. McGuire WP Hoskins WJ Brady MF . Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer . N Engl J Med 1996
Matthew D. Galsky, Harry W. Herr, and Dean F. Bajorin
: 3020 – 3028 . 4 Herr HW : Surgical factors in bladder cancer: more (nodes) + more (pathology) = less (mortality) . BJU Int 2003 ; 92 : 187 – 188 . 5 Herr HW : Extent of surgery and pathology evaluation has an impact on bladder
Ernest S. Han and Mark Wakabayashi
Advanced-stage disease (stage III–IV) is diagnosed in 75% to 85% of patients, and standard management generally involves cytoreductive surgery and platinum/taxane-based chemotherapy. 2 Novel strategies and technologies are desperately needed to diagnose
Meaghan Tenney and Joan L. Walker
Gynecologic Oncology Group study (LAP2) . J Clin Oncol 2009 ( submitted ). 22 Malur S Possover M Michels W Schneider A . Laparoscopic-assisted vaginal versus abdominal surgery in patients with endometrial cancer--a prospective randomized trial
Christopher J. Long, Sameer Mittal, and Thomas F. Kolon
intrinsic renal disease are thought to contribute to the eventual development of renal failure in some patients, the loss of renal mass from tumor resection is also a potential factor. 2 Current Indications for Partial Nephrectomy Nephron-sparing surgery
Prajnan Das, Norio Fukami, and Jaffer A. Ajani
comparison with previous meta-analyses . Tumori 2002 ; 88 : 21 – 27 . 35. Macdonald JS Smalley SR Benedetti J . Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction . N Engl
