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Setting Up a Lung Cancer Screening Program

Douglas Arenberg and Ella A. Kazerooni

In November 2010, the National Lung Cancer Screening Trial (NLST) was halted by the NIH, with the compelling news that CT reduced lung cancer mortality by 20% and all-cause mortality by 7% when 3 annual low-dose helical CT scans were performed in

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Surgery for Early-Stage Small Cell Lung Cancer

Bryan J. Schneider, Ashish Saxena, and Robert J. Downey

The American Cancer Society estimates that 222,500 new cases of lung cancer occurred in the United States in 2010. Of these, small cell lung cancer (SCLC) constitutes approximately 14%, or approximately 30,000 new cases annually. 1 SCLC is

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Computed Tomography Screening for the Early Detection of Lung Cancer

Rebecca P. Petersen and David H. Harpole Jr.

stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression . Cancer Res 1995 ; 55 : 51 – 56 . 5. Parker SL Tong T Bolden S . Cancer statistics, 1997 . CA-Cancer J Clin 1997 ; 47 : 5 – 27

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Modern Staging of Small Cell Lung Cancer

Gregory P. Kalemkerian and Shirish M. Gadgeel

staging system for the classification of patients with SCLC. Describe the optimal staging work-up for patients with SCLC. Small cell lung cancer (SCLC) is characterized by neuroendocrine differentiation, early metastatic spread, and initial

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Systemic Therapy for Small Cell Lung Cancer

Benjamin Levy, Ashish Saxena, and Bryan J. Schneider

Small cell lung cancer (SCLC) constitutes approximately 15% of all lung cancers, with an estimated 33,900 new cases occurring in the United States in 2012. 1 SCLC is an aggressive tumor characterized by genetic complexity, rapid doubling time

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Treatment of Non–Small Cell Lung Cancer in the Older Patient

Apar Kishor Ganti, Mollie deShazo, Alva B. Weir III, and Arti Hurria

Lung cancer is the second most common malignancy and the leading cause of cancer-related death in the United States. 1 The median age of diagnosis of non–small cell lung cancer (NSCLC) is 70 years, and therefore it represents a major disease

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Operative Techniques in Early-Stage Lung Cancer

Thomas A. D'Amico

-stage non–small cell lung cancer (NSCLC), lobectomy with mediastinal lymph node dissection is considered the optimal treatment. 2 Segmentectomy, anatomic sublobar resection of one or more bronchopulmonary segments, has a role in the management of some

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The Optimal Use of Radiotherapy in Small Cell Lung Cancer

David B. Shultz, John C. Grecula, James Hayman, Maximilian Diehn, and Billy W. Loo Jr

Small cell lung cancer (SCLC) accounts for approximately 15% of all primary lung cancers 1 and is characterized by an aggressive clinical course. Unfortunately, most patients present with metastatic disease. For patients with locally advanced

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Association Between Pretreatment Chest Imaging and Immune Checkpoint Inhibitor Pneumonitis Among Patients With Lung Cancer

Alexander Wong, Maria Riley, Songzhu Zhao, Jessica Zimmer, Matthew Viveiros, Jing Gennie Wang, Vincent Esguerra, Mingjia Li, Gabrielle Lopez, Kari Kendra, David P. Carbone, Kai He, Asrar Alahmadi, Jacob Kaufman, Regan M. Memmott, Peter G. Shields, Jeremy Brownstein, Karl Haglund, Meng Welliver, Gregory A. Otterson, Carolyn J. Presley, Lai Wei, Dwight H. Owen, and Kevin Ho

Background Over the past decade, immune checkpoint inhibitors (ICIs) have had a pivotal impact on cancer treatment, particularly for lung cancer. 1 They have become first-line, adjuvant, and neoadjuvant therapy in the treatment of lung cancer

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Targeted/Emerging Therapies for Metastatic Non–Small Cell Lung Cancer

Leora Horn

, who is a panel member of the NCCN Guidelines Panel for Non–Small Cell Lung Cancer (NSCLC). Moving From Histology to Molecular Diagnostics The traditional view of NSCLC was to categorize disease by histologic subtypes, such as adenocarcinoma