pancreaticoduodenectomy was sent to Foundation Medicine (Cambridge, MA) for genomic analysis, which revealed an activating mutation in exon 19 (L747_P753>S) of EGFR with a mutation allele frequency (MAF) of 16%. Mutations were also detected in CDKN2A (splice site 144
Search Results
EGFR Exon 19 Deletion in Pancreatic Adenocarcinoma Responds to Erlotinib, Followed by T790M-Mediated Resistance
Michael Cecchini, Jeffrey Sklar, and Jill Lacy
Predictive Molecular Markers: Has the Time Come for Routine Use in Lung Cancer?
Angela M. Davies, Philip C. Mack, Primo N. Lara Jr., Derick H. Lau, Kathleen Danenberg, Paul H. Gumerlock, and David R. Gandara
; 7 : 1850 – 1855 . 32 Perez-Soler R Chachoua A Huberman M . A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum based chemotherapy, inpatients with advanced, EGFR
Emerging Treatments in Recurrent and Metastatic Colorectal Cancer
Kristen Keon Ciombor and Tanios Bekaii-Saab
treatment options for mCRC Appraise the recent clinical trial results of anti-EGFR and anti-VEGF therapies for determining optimal drug combinations and treatment sequences for mCRC Describe the 2 proven examples of genetic alterations leading to
Therapeutically Induced Changes in HER2, HER3, and EGFR Protein Expression for Treatment Guidance
Shankar Sellappan, Adele Blackler, Wei-Li Liao, Emily O'Day, Peng Xu, Sheeno Thyparambil, Fabiola Cecchi, Todd Hembrough, and Daniel V.T. Catenacci
(10.15/2.15 mean copy number/cell = 4.72 ratio). By next-generation sequencing (NGS), this biopsy demonstrated 9 copies of HER2 . The HER2, EGFR, and HER3 protein levels were also assessed by targeted mass spectrometry 5 ; the HER2 protein expression
HSR19-084: Real-World Treatment Patterns and Clinical Outcomes in Non-Small Cell Lung Cancer Patients with EGFR Exon 20 Insertion Mutations
Maral DerSarkissian, Shuanglian Li, Aaron Galaznik, Rachel Bhak, Iryna Bocharova, Thomas Kulalert, Huamao M. Lin, Hui Huang, and Mei Sheng Duh
Background: Mutations in the epidermal growth factor receptor (EGFR) gene have been identified in 10%–50% of patients with non-small cell lung cancer (NSCLC). Exon 20 insertion mutations represent about 2%–10% of this group. Reports of real world
Therapeutic Response of Metastatic Colorectal Cancer Harboring a KRAS Missense Mutation After Combination Chemotherapy With the EGFR Inhibitor Panitumumab
Emil Lou, Donna D'Souza, and Andrew C. Nelson
mutations do not benefit from treatment with epidermal growth factor receptor (EGFR) inhibitors. 4 During this time, there have been investigations examining whether this is broadly and universally true across all forms of KRAS mutations, or whether any
Early Application of Next-Generation Sequencing Identifies Pancreatic Mass as Metastasis From an EGFR-Mutated Lung Adenocarcinoma
Luxi Chen, John Davelaar, Srinivas Gaddam, Kambiz Kosari, Nicholas Nissen, George Chaux, Christopher Lee, Eric Vail, Andrew Hendifar, Jun Gong, Karen Reckamp, and Arsen Osipov
/irinotecan/oxaliplatin) as neoadjuvant therapy, NGS of the pancreatic tissue revealed EGFR (OMIM #131550) S768I and G719C gain of function (GoF) mutations. The S768I and G719C mutations are located in exons 20 and 18, respectively, within the tyrosine kinase domain of the
Biologics in Cervical Cancer Therapy
Lyndsay J. Willmott, Daniele A. Sumner, and Bradley J. Monk
Clinical Oncology. All rights reserved. Endothelial Growth Factor Receptor–Targeted Therapy Endothelial growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein that promotes cell growth in various normal and transformed tissues
The Biologic Spectrum of Thymic Epithelial Neoplasms: Current Status and Future Prospects
Richard T. Cheney
-assisted microdissection to generate epithelial cell–enriched material 51 to circumvent this problem. Perhaps of most interest, at least from a therapeutic standpoint, are studies of the epidermal growth factor receptor (EGFR) and the tyrosine kinase receptor, c
CLO19-033: Afatinib Followed by Osimertinib in EGFR Mutation-Positive (EGFRm+) Advanced NSCLC: Subgroup Analyses of the GioTag Study by ECOG PS, Age, and Ethnicity
Balazs Halmos, Maximilian J. Hochmair, Alessandro Morabito, Desiree Hao, Cheng-Ta Yang, Ross A. Soo, James C-H Yang, Rasim Gucalp, Lara Wang, Angela Märten, and Tanja Cufer
Background: EGFR TKIs have shown first-line efficacy in EGFR m+ NSCLC but acquired resistance is inevitable; with afatinib, this is predominantly through the emergence of T790M. Therefore, a key consideration when assessing therapeutic choices is
