cetuximab or panitumumab. Approximately 5% to 9% of CRCs are characterized by a specific mutation in the BRAF gene (V600E). 155 , 156 BRAF mutations are, for all practical purposes, limited to tumors that do not have KRAS exon 2 mutations. 155 , 157
Search Results
Al B. Benson III, Alan P. Venook, Lynette Cederquist, Emily Chan, Yi-Jen Chen, Harry S. Cooper, Dustin Deming, Paul F. Engstrom, Peter C. Enzinger, Alessandro Fichera, Jean L. Grem, Axel Grothey, Howard S. Hochster, Sarah Hoffe, Steven Hunt, Ahmed Kamel, Natalie Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Mary F. Mulcahy, James D. Murphy, Steven Nurkin, Leonard Saltz, Sunil Sharma, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Elena M. Stoffel, Eden Stotsky-Himelfarb, Christopher G. Willett, Christina S. Wu, Kristina M. Gregory, and Deborah Freedman-Cass
Henry G. Kaplan, Steven Rostad, Jeffrey S. Ross, Siraj M. Ali, and Sherri Z. Millis
Institutional Review Board (IRB)–approved protocol (No. SWD5531S-14). MPNSTs were studied using the QIAGEN QIAamp DNA FFPE Tissue Kit and BRAF mutation was analyzed using a laboratory-developed, allele-specific, real-time PCR assay to detect the major BRAF
Letizia Gandolfi, Sarah Adamo, Alessandro Pileri, Alessandro Broccoli, Lisa Argnani, and Pier Luigi Zinzani
BRAF constitutive activation independently of extracellular signals. 15 The BRAF mutation is detected in many malignant diseases, including primary melanoma, hairy cell leukemia, papillary thyroid carcinoma, colorectal cancer, and in approximately
Noman Ashraf, Nishi Kothari, and Richard Kim
the same intracellular pathways, it is plausible that BRAF mutation status may also have predictive value for anti-EGFR therapy. 40 , 51 Early studies supported such a role; however, pooled data from the CRYSTAL and OPUS trials showed no
Matthew F. Kalady
. The sequence of events is still not completely characterized, but the belief is that a BRAF mutation is the initiating event, with conversion of normal mucosa to either a microvesicular hyperplastic polyp or an SSA/P. DNA hypermethylation (CIMP) of
Michael S. Lee, David G. Menter, and Scott Kopetz
also enriched for MSI-high, CIMP-high, and BRAF mutation. Although genotypic features such as KRAS and BRAF mutation status are enriched in some subtypes (ie, BRAF in CMS1; KRAS in CMS3), their presence or absence does not specifically define
Presenters: Jane Yanagawa and Gregory J. Riely
rearrangements, BRAF mutations, NTRK1 /2/3 rearrangements, MET exon 14 skipping mutations, and RET rearrangements. EGFR Tyrosine Kinase Inhibitors EGFR mutations are one of the most common oncogenic drivers in NSCLC and have served as the paradigm
Karina Mayra Aliaga, Fradis Gil-Olivares, Laura Pérez, Gisely Hijar, Edward López, Cindy Alcarraz, Mariana Serrano, Claudio Flores, Alonso Díaz, Jose Gutierrez, and Alfredo Aguilar
RAS and BRAF mutational status to patients with metastatic CRC and percentage of patients who received recommended therapy according to the RAS and/or BRAF mutational status. Methods: A descriptive analysis was performed. Indicators were compared
Krishna Desai, Kristal Pereira, Akhil Jain, Sabah Iqbal, and Rajesh Thirumaran
, fluorouracil, & oxaliplatin) was started, but a new metastatic lesion in the liver was found. In the interim, NGS was positive for IDH-1 & BRAF mutation. Since he was progressing, target therapy with Ivosidenib was added for IDH-1, as per NGS. At 2 year follow
