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Biomarker-Based Treatment Selection in Non–Small Cell Lung Cancer

Wallace Akerley

gefitinib (an EGFR inhibitor) versus carboplatin/paclitaxel ( P <.001), whereas those who were EGFR -negative had significantly improved PFS on carboplatin/paclitaxel versus gefitinib ( P <.001). 2 “This early study showed that PFS was significantly

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In Chemotherapy for Lung Cancer, Sometimes Less is More

Eric Roeland, Charles Loprinzi, Timothy J. Moynihan, Thomas J. Smith, and Jennifer Temel

cytotoxic agents in patients in similar settings: 2 months for bevacizumab when added to carboplatin/paclitaxel and 2.6 months for maintenance pemetrexed. 17 , 18 Although the possibility of prolonged survival with supportive care interventions has been

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Ten Years of Progress in Non–Small Cell Lung Cancer

David S. Ettinger

empiric, usually a platinum-based doublet. However in 2006, the FDA approved use of the anti-vascular endothelial growth factor monoclonal antibody, bevacizumab, with paclitaxel and carboplatin (PCB). This approval was based on the results of the ECOG

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Supportive Care in Head and Neck Cancers: Multidisciplinary Management

Presented by: Jimmy J. Caudell, David G. Pfister, and Randal S. Weber

chemotherapy (as was the standard at the time) with carboplatin and paclitaxel for 2 cycles. According to Dr. Caudell, this patient did well for years, but in 2019 presented with perceived slurring of speech. On examination, his tongue deviated to the right

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The Role of Inhibitors of the Epidermal Growth Factor in Management of Head and Neck Cancer

Bruce Brockstein, Mario Lacouture, and Mark Agulnik

Edited by Kerrin G. Robinson

. Hitt R Irigoyen A Nunez J . Phase II study of combination cetuximab plus weekly paclitaxel in patients with recurrent and/or metastatic squamous cell cancer of the head and neck (SCCHN) [abstract] . J Clin Oncol 2007 ; 25 ( Suppl 1 ): Abstract 6012

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Bladder Cancer

James E. Montie, Peter E. Clark, Mario A. Eisenberger, Rizk El-Galley, Richard E. Greenberg, Harry W. Herr, Gary R. Hudes, Deborah A. Kuban, Timothy M. Kuzel, Paul H. Lange, Subodh M. Lele, Jeffrey Michalski, Anthony Patterson, Kamal S. Pohar, Jerome P. Richie, Wade J. Sexton, William U. Shipley, Eric J. Small, Donald L. Trump, Phillip J. Walther, and Timothy G. Wilson

. Gemcitabine plus cisplatin for advanced transitional cell carcinoma of the urinary tract: a phase II multicenter trial . J Urol 2000 ; 164 : 53 – 56 . 49 Meluch AA Greco FA Burris HA III . Paclitaxel and gemcitabine chemotherapy for advanced

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NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024

Featured Updates to the NCCN Guidelines

Nadeem R. Abu-Rustum, Catheryn M. Yashar, Rebecca Arend, Emma Barber, Kristin Bradley, Rebecca Brooks, Susana M. Campos, Junzo Chino, Hye Sook Chon, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Stephanie Gaillard, Robert Giuntoli II, Scott Glaser, Jordan Holmes, Brooke E. Howitt, Jayanthi Lea, Gina Mantia-Smaldone, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Mirna Podoll, Kerry Rodabaugh, Ritu Salani, John Schorge, Jean Siedel, Rachel Sisodia, Pamela Soliman, Stefanie Ueda, Renata Urban, Emily Wyse, Nicole R. McMillian, Shaili Aggarwal, and Sara Espinosa

radiosensitizing agents that could be considered for use only when cisplatin and carboplatin are unavailable (see CERV-F 1 of 3 , above). The options of capecitabine/mitomycin, gemcitabine, and paclitaxel were added under “Other Recommended Regimens” as

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First-Line Systemic Therapy Practice Patterns and Concordance With NCCN Guidelines for Patients Diagnosed With Metastatic NSCLC Treated at NCCN Institutions

Carrie Zornosa, Jonathan L. Vandergrift, Gregory P. Kalemkerian, David S. Ettinger, Michael S. Rabin, Mary Reid, Gregory A. Otterson, Marianna Koczywas, Thomas A. D'Amico, Joyce C. Niland, Rizvan Mamet, and Katherine M. Pisters

platinum-based regimens varied from 4% to 22%. Table 2 Off-Trial First-Line Systemic Drug Therapy Combinations Used According to Therapy Type (n = 1131) Paclitaxel was the most common cytotoxic partner agent combined with a platinum agent (n

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Comparison of Overall Survival Between Preoperative Chemotherapy and Chemoradiotherapy for Resectable Pancreatic Adenocarcinoma

Ali A. Mokdad, Rebecca M. Minter, Adam C. Yopp, Matthew R. Porembka, Sam C. Wang, Hong Zhu, Mathew M. Augustine, John C. Mansour, Michael A. Choti, and Patricio M. Polanco

. 2 – 5 Improvement in CT regimens in recent years is yet another compelling reason to invest in trials evaluating preoperative therapy in PaC. For example, multiagent CT regimens, such as FOLFIRINOX 24 and gemcitabine/nab-paclitaxel, 25 , 26 which

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Trends in Neoadjuvant Approaches in Pancreatic Cancer

Lingling Du and Andrea Wang-Gillam

therapy has been a main challenge in the neoadjuvant setting. In the meantime, recent studies have shown that both FOLFIRINOX and nab-paclitaxel plus gemcitabine improved survival in patients with advanced PDAC. 21 , 22 These regimens were noted to have