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Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology

Nadeem Abu-Rustum, Catheryn Yashar, Rebecca Arend, Emma Barber, Kristin Bradley, Rebecca Brooks, Susana M. Campos, Junzo Chino, Hye Sook Chon, Christina Chu, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Robert Giuntoli II, Ernest Han, Jordan Holmes, Brooke E. Howitt, Jayanthi Lea, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Mirna Podoll, Ritu Salani, John Schorge, Jean Siedel, Rachel Sisodia, Pamela Soliman, Stefanie Ueda, Renata Urban, Stephanie L. Wethington, Emily Wyse, Kristine Zanotti, Nicole R. McMillian, and Shaili Aggarwal

Overview Endometrial carcinoma is a malignant epithelial tumor that forms in the inner lining, or endometrium, of the uterus. Risk factors for endometrial carcinomas include increased levels of estrogen (caused by obesity, diabetes, unopposed

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Misdiagnosis of Li-Fraumeni Syndrome in a Patient With Clonal Hematopoiesis and a Somatic TP53 Mutation

Rachel L. Mitchell, Cory Kosche, Kelly Burgess, Shreya Wadhwa, Lela Buckingham, Ritu Ghai, Jacob Rotmensch, Oleksandra Klapko, and Lydia Usha

the gene. 2 This report presents a misdiagnosis of LFS in a patient with fallopian tube carcinoma. On further analysis, a TP53 mutation identified in her blood sample was determined to be a somatic mutation present in a hematopoietic clone

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Efficacy and Toxicity Analysis of mFOLFIRINOX in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms

Michele Borghesani, Anna Reni, Eleonora Lauricella, Alice Rossi, Viola Moscarda, Elena Trevisani, Irene Torresan, Taymeyah Al-Toubah, Elisabetta Filoni, Claudio Luchini, Riccardo De Robertis, Luca Landoni, Aldo Scarpa, Camillo Porta, Michele Milella, Jonathan Strosberg, Mauro Cives, and Sara Cingarlini

-differentiated grade 3 (G3) neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). 2 Gastroenteropancreatic NECs (GEP-NECs) may contain a non-neuroendocrine component, including adenocarcinoma, signet ring cell carcinoma, or squamous

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Perspectives on Margins in DCIS: Pathology

Susan Lester

to the ducts and lobules or as carcinoma in situ (CIS). However, for women undergoing mammographic screening, most cancers (70%–80%) are detected only after the basement membrane has been breached and an invasive carcinoma is present. Thus, the

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CLO20-068: Incidence and Potential Predictors of Thromboembolic Events in Epithelial Ovarian Carcinoma Patients During Perioperative Period

Qingqing Zhou, Chenchen Zhu, Zhen Shen, Jing Zhu, Tianjiao Zhang, Min Li, Jiwei Qin, Lili Qian, Chuan Chen, Hanyuan Liu, Zhihao Xu, Dabao Wu, Björn Nashan, and Ying Zhou

Objective: To assess the incidence and the risk factors of venous thromboembolism (VTE) in patients with epithelial ovarian carcinoma (EOC) during perioperative period. Methods: A retrospective analysis was conducted on the patients with

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CLO21-028: Clinical Outcomes for Advanced Hepatocellular Carcinoma Patients Treated With Systemic Agents in Real-World Practice

Karine Tawagi, Diana Maslov, Madhav KC, Danny Markabawi, Suresh Mukkamala, Fady Farag, Helen Yuan, Adi Bamnolker, Rula Saeed, Zoe Blake, Marc Matrana, and Daniel Johnson

Background: Despite new approvals in the treatment of advanced hepatocellular carcinoma (HCC), there is a knowledge gap regarding the safety of these agents in patients with a more advanced Child Pugh score (B or C). Further investigation into the

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CLO22-063: Study on Correlation Between Serum CA 19-9 and Colorectal Carcinoma With Normal CEA

Avisikta Mallick and Arkaprovo Roy

differentiated to mucinous/signet ring cell type carcinomas. But this finding was not found to be statistically significant. Conclusion : A combination of CA 19-9 and CEA can be utilized as diagnostic markers for advanced stages of CRC.

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Depression and Pancreatic Cancer

Andrew D. Boyd and Michelle Riba

-2002 . Available at: http://seer.cancer.gov/cgibin/csr/1975_2002/search.pl#results . Accessed November 1, 2006 . 2. Fras I Litin EM Bartholomew LG . Mental symptoms as an aid in the early diagnosis of carcinoma of the pancreas . Gastroenterology

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CLO21-030: Does the TP53 Mutation Worsen Prognosis in Carriers of BRCA1/2 Deficiency With Grade 3 Endometrioid Endometrial Carcinoma?

Aifen Wang, Yong Yin, Jinhua Zhou, Fangrong Shen, and Youguo Chen

Objective: We aimed to identify the clinical importance of BRCA1/2 deficiencies with respect to TP53 mutation status in 184 patients with grade 3 endometrioid endometrial carcinoma. Methods: This was a retrospective cohort study which utilized

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CRE24-037: Navigating the Challenges of NUT Midline Carcinoma: A Case Study and Therapeutic Insights for an Aggressive Oncologic Enigma

Anas Alqam and Phu V. Truong

NUT midline carcinoma (NMC) is an aggressive form of squamous cell carcinoma primarily affecting the head and neck, and its prevalence remains unknown. Sadly, there is no established standard treatment for NMC, and patients usually face a grim