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recurrence or PCSM (eg, men with adverse postsurgery pathology, pathologic T3 disease, increasing PSA levels, or positive surgical margins) in whom treatment amelioration/addition is suggested. Grouping of the interventions was based on published literature

requires specialized technical resources and expertise and is therefore not available in all pathology laboratories. In particular, due to (1) the intrachromosomal deletion and inversion event that underlies most ALK rearrangements in NSCLC and (2

This was a hands-on multidisciplinary workshop in which clinicians, scientists, and advocacy partners met to discuss areas requiring further development, including understanding patients’ needs, deciphering the molecular pathology of adult

with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology . J Mol Diagn 2012 ; 14 : 525 – 540 . 15. Manolio TA Chisholm RL Ozenberger B . Implementing genomic medicine in the clinic: the future is

and F-18 fluciclovine PET scans may help distinguish patients with indolent versus occult metastatic disease. Figure 1 illustrates the interaction between clinical disease features, family history, and pathology to determine who should be offered

, and perhaps neuropsychologic testing are important steps in the evaluation and treatment of these symptoms. 1 Organic brain pathology can cause psychiatric symptoms, 29 such as pseudobulbar affect in patients with ECD. 9 , 30 This neurologic

Grade and Depth of Myometrial Invasion Pathology A key component of the added value of SLN procedures in endometrial cancer is enhanced pathology, also known as ultrastaging . At the authors’ institution, the protocol for SLN evaluation is

picture of the molecular landscapes of cancer and many insights into the molecular pathology of cancers are accruing. Genomic databases such as cBioPortal ( www.cbiopartal.org ) 8 are providing access to large-scale genomic data where inferences can be

the data used to derive the model? Because nomograms are typically developed from retrospective data (with their inherent selection and reporting biases), the quality of the native data must be understood (e.g., was a central pathology review performed

personal connection, critical for a trusting and supportive relationship. Then, from various digital sources, we must evaluate pathology, genomics, imagining, and laboratory results to characterize our patient's condition. Then I use my knowledge and