empiric, usually a platinum-based doublet. However in 2006, the FDA approved use of the anti-vascular endothelial growth factor monoclonal antibody, bevacizumab, with paclitaxel and carboplatin (PCB). This approval was based on the results of the ECOG
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Presenters: Jimmy J. Caudell, David G. Pfister, and Randal S. Weber
chemotherapy (as was the standard at the time) with carboplatin and paclitaxel for 2 cycles. According to Dr. Caudell, this patient did well for years, but in 2019 presented with perceived slurring of speech. On examination, his tongue deviated to the right
Lingling Du and Andrea Wang-Gillam
therapy has been a main challenge in the neoadjuvant setting. In the meantime, recent studies have shown that both FOLFIRINOX and nab-paclitaxel plus gemcitabine improved survival in patients with advanced PDAC. 21 , 22 These regimens were noted to have
Jaffer A. Ajani, Thomas A. D’Amico, David J. Bentrem, Joseph Chao, David Cooke, Carlos Corvera, Prajnan Das, Peter C. Enzinger, Thomas Enzler, Paul Fanta, Farhood Farjah, Hans Gerdes, Michael K. Gibson, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Rajesh N. Keswani, Sunnie Kim, Lawrence R. Kleinberg, Samuel J. Klempner, Jill Lacy, Quan P. Ly, Kristina A. Matkowskyj, Michael McNamara, Mary F. Mulcahy, Darryl Outlaw, Haeseong Park, Kyle A. Perry, Jose Pimiento, George A. Poultsides, Scott Reznik, Robert E. Roses, Vivian E. Strong, Stacey Su, Hanlin L. Wang, Georgia Wiesner, Christopher G. Willett, Danny Yakoub, Harry Yoon, Nicole McMillian, and Lenora A. Pluchino
paclitaxel with either cisplatin or carboplatin, 114 – 116 docetaxel with cisplatin, 117 , 118 or single-agent fluoropyrimidine (fluorouracil or capecitabine), 85 , 119 , 120 docetaxel, 77 , 121 or paclitaxel. 122 , 123 Docetaxel, carboplatin, and
Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force
followed by paclitaxel. Figure 5 Reframed thinking on adjuvant therapy: the generation lineages and chains of interference. Therefore, the overall data suggest a benefit with anthracycline either in lieu of or added to CMF. However, not all anthracycline
Ali A. Mokdad, Rebecca M. Minter, Adam C. Yopp, Matthew R. Porembka, Sam C. Wang, Hong Zhu, Mathew M. Augustine, John C. Mansour, Michael A. Choti, and Patricio M. Polanco
. 2 – 5 Improvement in CT regimens in recent years is yet another compelling reason to invest in trials evaluating preoperative therapy in PaC. For example, multiagent CT regimens, such as FOLFIRINOX 24 and gemcitabine/nab-paclitaxel, 25 , 26 which
Carrie Zornosa, Jonathan L. Vandergrift, Gregory P. Kalemkerian, David S. Ettinger, Michael S. Rabin, Mary Reid, Gregory A. Otterson, Marianna Koczywas, Thomas A. D'Amico, Joyce C. Niland, Rizvan Mamet, and Katherine M. Pisters
platinum-based regimens varied from 4% to 22%. Table 2 Off-Trial First-Line Systemic Drug Therapy Combinations Used According to Therapy Type (n = 1131) Paclitaxel was the most common cytotoxic partner agent combined with a platinum agent (n
Catherine Larkin
bevacizumab should no longer be marketed for breast cancer. The FDA began the process of finalizing that recommendation on December 16, 2010, the same day the European Medicines Agency said bevacizumab should still be used with paclitaxel in treating breast
Thomas W. Flaig
phase III trial, which randomly assigned 542 patients whose disease had progressed on platinum-based therapy to either pembrolizumab or investigator’s choice of chemotherapy (vinflunine, paclitaxel, or docetaxel), pembrolizumab demonstrated significantly
Jaffer A. Ajani, Thomas A. D'Amico, Khaldoun Almhanna, David J. Bentrem, Joseph Chao, Prajnan Das, Crystal S. Denlinger, Paul Fanta, Farhood Farjah, Charles S. Fuchs, Hans Gerdes, Michael Gibson, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kimberly L. Johung, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, Stephen Leong, Catherine Linn, A. Craig Lockhart, Quan P. Ly, Mary F. Mulcahy, Mark B. Orringer, Kyle A. Perry, George A. Poultsides, Walter J. Scott, Vivian E. Strong, Mary Kay Washington, Benny Weksler, Christopher G. Willett, Cameron D. Wright, Debra Zelman, Nicole McMillian, and Hema Sundar
patients with advanced gastric cancer. Irinotecan (single agent or in combination with other cytotoxic agents) has also been evaluated in the second line setting. 71 – 76 In a randomized phase III study that compared irinotecan with paclitaxel in 223
