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Kevin S. Scher, Juan-Sebastian Saldivar, Michael Fishbein, Alberto Marchevsky, and Karen L. Reckamp

node dissection. Pathology results showed a moderately differentiated adenocarcinoma without evidence of squamous histology in any of the specimens. Margins were focally positive at the hilar and perivascular soft tissue margin. Of the 10 sampled lymph

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Rishi Agarwal, Jiang Wang, Keith Wilson, William Barrett, and John C. Morris

demonstrated a paralyzed left vocal cord. The patient underwent an attempt at left thyroidectomy with tumor resection that also involved the esophagus and jugular vein, and a limited left neck dissection. Pathology was consistent with anaplastic

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Lieke Gietelink, Michel W.J.M. Wouters, Pieter J. Tanis, Marion M. Deken, Martijn G. ten Berge, Rob A.E.M. Tollenaar, J. Han van Krieken, Mirre E. de Noo, and on behalf of the Dutch Surgical Colorectal Cancer Audit Group

pathology protocol to examine a TME specimen was introduced in the 1990s, related to the start of the Dutch TME trial. 5 Because of this standardization, 97% of patients included in this trial had a reported CRM. 2 In subsequent years, until the start of

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Aysegul A. Sahin, Timothy D. Gilligan, and Jimmy J. Caudell

margins. We also look at markers of proliferation and possibly tumor infiltrating lymphocytes,” explained Aysegul A. Sahin, MD, Director of Educational Operations, and Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center

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Michelle C. Nguyen, Manisha H. Shah, David A. Liebner, Floor J. Backes, John Phay, and Lawrence A. Shirley

craniotomy and resection of a hemorrhagic brain lesion, with pathology results consistent with a 2.8-cm deposit of metastatic melanoma. Whole-brain radiation therapy (RT) with 30 Gy and 5 cycles of ipilimumab were completed, and restaging scans demonstrated

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Victor T.G. Lin, Lisle M. Nabell, Sharon A. Spencer, William R. Carroll, Shuko Harada, and Eddy S. Yang

biopsy, followed by a left modified radical neck dissection and left total parotidectomy. Pathology from his surgical resection revealed a high-grade, locally advanced (pT4aN2b,cM0) SDC with multiple high-risk features, including a positive margin of

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Julia T. van Groningen, Pieter van Hagen, Rob A.E.M. Tollenaar, Jurriaan B. Tuynman, Perla J. Marang-van de Mheen, Pascal G. Doornebosch, Pieter J. Tanis, Eelco J.R. de Graaf, and on behalf of the Dutch Colorectal Audit

with TME. 8 , 9 If the pathology of the local excision specimen shows a high-risk T1 rectal cancer or if the tumor is ≥T2, the patient will have unacceptable, high recurrence rates (>15%) and possibly reduced survival without further treatment compared

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Therese B. Bevers, Benjamin O. Anderson, Ermelinda Bonaccio, Sandra Buys, Mary B. Daly, Peter J. Dempsey, William B. Farrar, Irving Fleming, Judy E. Garber, Randall E. Harris, Alexandra S. Heerdt, Mark Helvie, John G. Huff, Nazanin Khakpour, Seema A. Khan, Helen Krontiras, Gary Lyman, Elizabeth Rafferty, Sara Shaw, Mary Lou Smith, Theodore N. Tsangaris, Cheryl Williams, and Thomas Yankeelov

close observation may be substituted for excisional biopsy in select patients. 83 , 90 , 97 - 99 Duct Excision With or Without Prior Ductography Nipple discharge is common and often unrelated to breast pathology. 100 , 101 For example

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Therese B. Bevers, Mark Helvie, Ermelinda Bonaccio, Kristine E. Calhoun, Mary B. Daly, William B. Farrar, Judy E. Garber, Richard Gray, Caprice C. Greenberg, Rachel Greenup, Nora M. Hansen, Randall E. Harris, Alexandra S. Heerdt, Teresa Helsten, Linda Hodgkiss, Tamarya L. Hoyt, John G. Huff, Lisa Jacobs, Constance Dobbins Lehman, Barbara Monsees, Bethany L. Niell, Catherine C. Parker, Mark Pearlman, Liane Philpotts, Laura B. Shepardson, Mary Lou Smith, Matthew Stein, Lusine Tumyan, Cheryl Williams, Mary Anne Bergman, and Rashmi Kumar

) is performed, concordance between the pathology report and the imaging finding must be obtained. 11 , 12 For example, a negative needle biopsy associated with a spiculated category 5 mass (highly suggestive of malignancy) is discordant and clearly

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Ghadeer Olleik, Wassim Kassouf, Armen Aprikian, Jason Hu, Marie Vanhuyse, Fabio Cury, Stuart Peacock, Elin Bonnevier, Ebba Palenius, and Alice Dragomir

recurrence or PCSM (eg, men with adverse postsurgery pathology, pathologic T3 disease, increasing PSA levels, or positive surgical margins) in whom treatment amelioration/addition is suggested. Grouping of the interventions was based on published literature