breast revealed 7 cm of multifocal IDC, grade 2, and 7 cm of intermediate-grade DCIS, 0.1 cm from the deep margin. One of 17 lymph nodes was involved, measuring 1.6 cm with extranodal extension. Pathology of the left breast showed 3 foci of IDC
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Monique A. de Bruin, James M. Ford, and Allison W. Kurian
Lieke Gietelink, Michel W.J.M. Wouters, Pieter J. Tanis, Marion M. Deken, Martijn G. ten Berge, Rob A.E.M. Tollenaar, J. Han van Krieken, Mirre E. de Noo, and on behalf of the Dutch Surgical Colorectal Cancer Audit Group
pathology protocol to examine a TME specimen was introduced in the 1990s, related to the start of the Dutch TME trial. 5 Because of this standardization, 97% of patients included in this trial had a reported CRM. 2 In subsequent years, until the start of
Saranya Chumsri, Ethan S. Sokol, Aixa E. Soyano-Muller, Ricardo D. Parrondo, Gina A. Reynolds, Aziza Nassar, and E. Aubrey Thompson
subsequently underwent right modified radical mastectomy with axillary lymph node dissection. Pathology results showed multifocal residual disease measuring up to 16.5 cm, with >10 additional satellite tumors and skin involvement. Among resected axillary lymph
Emil Lou, Donna D'Souza, and Andrew C. Nelson
. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology . Genet Med 2015 ; 17 : 405 – 424 . 22
Kevin S. Scher, Juan-Sebastian Saldivar, Michael Fishbein, Alberto Marchevsky, and Karen L. Reckamp
node dissection. Pathology results showed a moderately differentiated adenocarcinoma without evidence of squamous histology in any of the specimens. Margins were focally positive at the hilar and perivascular soft tissue margin. Of the 10 sampled lymph
Rishi Agarwal, Jiang Wang, Keith Wilson, William Barrett, and John C. Morris
demonstrated a paralyzed left vocal cord. The patient underwent an attempt at left thyroidectomy with tumor resection that also involved the esophagus and jugular vein, and a limited left neck dissection. Pathology was consistent with anaplastic
Aysegul A. Sahin, Timothy D. Gilligan, and Jimmy J. Caudell
margins. We also look at markers of proliferation and possibly tumor infiltrating lymphocytes,” explained Aysegul A. Sahin, MD, Director of Educational Operations, and Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center
Therese B. Bevers, Benjamin O. Anderson, Ermelinda Bonaccio, Sandra Buys, Mary B. Daly, Peter J. Dempsey, William B. Farrar, Irving Fleming, Judy E. Garber, Randall E. Harris, Alexandra S. Heerdt, Mark Helvie, John G. Huff, Nazanin Khakpour, Seema A. Khan, Helen Krontiras, Gary Lyman, Elizabeth Rafferty, Sara Shaw, Mary Lou Smith, Theodore N. Tsangaris, Cheryl Williams, and Thomas Yankeelov
close observation may be substituted for excisional biopsy in select patients. 83 , 90 , 97 - 99 Duct Excision With or Without Prior Ductography Nipple discharge is common and often unrelated to breast pathology. 100 , 101 For example
Therese B. Bevers, Mark Helvie, Ermelinda Bonaccio, Kristine E. Calhoun, Mary B. Daly, William B. Farrar, Judy E. Garber, Richard Gray, Caprice C. Greenberg, Rachel Greenup, Nora M. Hansen, Randall E. Harris, Alexandra S. Heerdt, Teresa Helsten, Linda Hodgkiss, Tamarya L. Hoyt, John G. Huff, Lisa Jacobs, Constance Dobbins Lehman, Barbara Monsees, Bethany L. Niell, Catherine C. Parker, Mark Pearlman, Liane Philpotts, Laura B. Shepardson, Mary Lou Smith, Matthew Stein, Lusine Tumyan, Cheryl Williams, Mary Anne Bergman, and Rashmi Kumar
) is performed, concordance between the pathology report and the imaging finding must be obtained. 11 , 12 For example, a negative needle biopsy associated with a spiculated category 5 mass (highly suggestive of malignancy) is discordant and clearly
Ghadeer Olleik, Wassim Kassouf, Armen Aprikian, Jason Hu, Marie Vanhuyse, Fabio Cury, Stuart Peacock, Elin Bonnevier, Ebba Palenius, and Alice Dragomir
recurrence or PCSM (eg, men with adverse postsurgery pathology, pathologic T3 disease, increasing PSA levels, or positive surgical margins) in whom treatment amelioration/addition is suggested. Grouping of the interventions was based on published literature
