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Small Cell Lung Cancer

UCSF Helen Diller Family Comprehensive Cancer Center

Small cell lung cancer (SCLC) accounts for 15% of lung cancers. Nearly all cases of SCLC are attributable to cigarette smoking, and the remaining cases are presumably caused by environmental or genetic factors. Compared with non-small cell lung cancer, SCLC generally has a more rapid doubling time, a higher growth fraction, and earlier development of widespread metastases. SCLC is highly sensitive to initial chemotherapy and radiotherapy, but most patients eventually die from recurrent disease. These guidelines detail the management of SCLC from initial diagnosis and staging through treatment, and include information on supportive and palliative care. Important updates to the 2008 version include refined categories for performance status and the addition of topotecan as an option for patients who experience relapse.

For the most recent version of the guidelines, please visit NCCN.org

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Do Outcomes in Elective Colon and Rectal Cancer Surgery Differ by Weekday? An Observational Study Using Data From the Dutch ColoRectal Audit

Daniëlle D. Huijts, Onno R. Guicherit, Jan Willem T. Dekker, Julia T. van Groningen, Leti van Bodegom-Vos, Esther Bastiaannet, Johannes A. Govaert, Michel W. Wouters, and Perla J. Marang-van de Mheen

Background Although surgery has a crucial role in colorectal cancer (CRC) treatment, it is associated with considerable risks of postoperative complications and mortality 1 , 2 and a resultant increase in healthcare costs. 3 Severe complications

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Lung Cancer Screening

Douglas E. Wood, George A. Eapen, David S. Ettinger, Lifang Hou, David Jackman, Ella Kazerooni, Donald Klippenstein, Rudy P. Lackner, Lorriana Leard, Ann N. C. Leung, Pierre P. Massion, Bryan F. Meyers, Reginald F. Munden, Gregory A. Otterson, Kimberly Peairs, Sudhakar Pipavath, Christie Pratt-Pozo, Chakravarthy Reddy, Mary E. Reid, Arnold J. Rotter, Matthew B. Schabath, Lecia V. Sequist, Betty C. Tong, William D. Travis, Michael Unger, and Stephen C. Yang

Lung cancer is the leading cause of cancer-related mortality in the United States and worldwide. 1 – 4 In 2011, it is estimated that 156,900 deaths (85,600 in men, 71,300 in women) from lung cancer will occur in the United States. 4 Five

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Chronic Pain Management in Cancer Survivors

Natalie Moryl, Nessa Coyle, Samuel Essandoh, and Paul Glare

U nfortunately, some cancer survivors with chronic cancer-related pain meet significant barriers limiting their access to medications previously determined effective and well-tolerated. An unintended consequence is pain that had been well

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Paid Sick Leave Among Working Cancer Survivors and Its Associations With Use of Preventive Services in the United States

Zhiyuan Zheng, Stacey A. Fedewa, Farhad Islami, Leticia Nogueira, Xuesong Han, Jingxuan Zhao, Weishan Song, Ahmedin Jemal, and K. Robin Yabroff

Background Approximately 33% of cancer survivors are in their prime working age range, between 20 and 64 years. 1 A cancer diagnosis can alter employment trajectories and cause long-term productivity losses. 2 Previous research showed that

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Population-Based Study on Cancer Subtypes, Guideline-Concordant Adjuvant Therapy, and Survival Among Women With Stage I–III Breast Cancer

Mei-Chin Hsieh, Lu Zhang, Xiao-Cheng Wu, Mary B. Davidson, Michelle Loch, and Vivien W. Chen

Background Since the molecular phenotypes of breast carcinomas were distinguished by gene expression patterns in 2000, breast cancer is no longer considered a single disease but rather a group of molecularly distinct neoplastic disorders. 1 – 4

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Association of Chronic Immune-Mediated Diarrhea and Colitis With Favorable Cancer Response

Fangwen Zou, Hamzah Abu-Sbeih, Weijie Ma, Yuanzun Peng, Wei Qiao, Jianbo Wang, Amishi Y. Shah, Isabella C. Glitza Oliva, Sarina A. Piha-Paul, John A. Thompson, Hao Chi Zhang, Anusha S. Thomas, and Yinghong Wang

Background Immune checkpoint inhibitor (ICI) therapy significantly improves cancer outcomes by targeting CLTA-4 or PD-1/L1 and boosting T-cell–mediated immune responses and antitumor effects. 1 , 2 ICIs are widely used as first-line therapy

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Prostate Biopsy Strategies: Current State of the Art

Badar M. Mian

The author has no financial interests, arrangement, or affiliations with the manufacturers of any products discussed in the article or with their competitors. References 1 Jemal A Murray T Samuels A . Cancer statistics, 2003

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New Issues in Systemic Therapy for Ovarian Cancer

Deborah K. Armstrong

Most patients with ovarian cancer are diagnosed with advanced-stage cancer. Debulking surgery followed by chemotherapy is recommended. The standard front-line regimen is 6 cycles of paclitaxel plus carboplatin, with docetaxel a reasonable

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Esophageal Cancer

The UNMC Eppley Cancer Center at The Nebraska Medical Center

Upper gastrointestinal (GI) tract cancers originating in the esophagus, gastroesophageal (GE) junctions, and stomach constitute a major health problem worldwide; esophageal cancer is the eighth most common cancer worldwide. An estimated 16,470 new cases of and 14,280 deaths from esophageal cancer will occur in the United States in 2008. Risk factors associated with development of esophageal cancer include age, male gender, Caucasian race, high body mass index, Barrett's esophagus, and history of gastroesophageal reflux disease. Important updates for the 2009 guidelines include a new page on “Principles of Best Supportive Care” that gives specific recommendations for esophageal cancer best supportive care throughout the guidelines.

To view the NCCN Clinical Practice Guidelines in Oncology on Gastric Cancers, please visit the NCCN Web site at www.nccn.org.

For the most recent version of the guidelines, please visit NCCN.org