margins. We also look at markers of proliferation and possibly tumor infiltrating lymphocytes,” explained Aysegul A. Sahin, MD, Director of Educational Operations, and Professor, Department of Pathology, The University of Texas MD Anderson Cancer Center
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Aysegul A. Sahin, Timothy D. Gilligan, and Jimmy J. Caudell
Kevin S. Scher, Juan-Sebastian Saldivar, Michael Fishbein, Alberto Marchevsky, and Karen L. Reckamp
node dissection. Pathology results showed a moderately differentiated adenocarcinoma without evidence of squamous histology in any of the specimens. Margins were focally positive at the hilar and perivascular soft tissue margin. Of the 10 sampled lymph
Saranya Chumsri, Ethan S. Sokol, Aixa E. Soyano-Muller, Ricardo D. Parrondo, Gina A. Reynolds, Aziza Nassar, and E. Aubrey Thompson
subsequently underwent right modified radical mastectomy with axillary lymph node dissection. Pathology results showed multifocal residual disease measuring up to 16.5 cm, with >10 additional satellite tumors and skin involvement. Among resected axillary lymph
Michelle C. Nguyen, Manisha H. Shah, David A. Liebner, Floor J. Backes, John Phay, and Lawrence A. Shirley
craniotomy and resection of a hemorrhagic brain lesion, with pathology results consistent with a 2.8-cm deposit of metastatic melanoma. Whole-brain radiation therapy (RT) with 30 Gy and 5 cycles of ipilimumab were completed, and restaging scans demonstrated
Therese B. Bevers, Benjamin O. Anderson, Ermelinda Bonaccio, Sandra Buys, Mary B. Daly, Peter J. Dempsey, William B. Farrar, Irving Fleming, Judy E. Garber, Randall E. Harris, Alexandra S. Heerdt, Mark Helvie, John G. Huff, Nazanin Khakpour, Seema A. Khan, Helen Krontiras, Gary Lyman, Elizabeth Rafferty, Sara Shaw, Mary Lou Smith, Theodore N. Tsangaris, Cheryl Williams, and Thomas Yankeelov
close observation may be substituted for excisional biopsy in select patients. 83 , 90 , 97 - 99 Duct Excision With or Without Prior Ductography Nipple discharge is common and often unrelated to breast pathology. 100 , 101 For example
Therese B. Bevers, Mark Helvie, Ermelinda Bonaccio, Kristine E. Calhoun, Mary B. Daly, William B. Farrar, Judy E. Garber, Richard Gray, Caprice C. Greenberg, Rachel Greenup, Nora M. Hansen, Randall E. Harris, Alexandra S. Heerdt, Teresa Helsten, Linda Hodgkiss, Tamarya L. Hoyt, John G. Huff, Lisa Jacobs, Constance Dobbins Lehman, Barbara Monsees, Bethany L. Niell, Catherine C. Parker, Mark Pearlman, Liane Philpotts, Laura B. Shepardson, Mary Lou Smith, Matthew Stein, Lusine Tumyan, Cheryl Williams, Mary Anne Bergman, and Rashmi Kumar
) is performed, concordance between the pathology report and the imaging finding must be obtained. 11 , 12 For example, a negative needle biopsy associated with a spiculated category 5 mass (highly suggestive of malignancy) is discordant and clearly
Ghadeer Olleik, Wassim Kassouf, Armen Aprikian, Jason Hu, Marie Vanhuyse, Fabio Cury, Stuart Peacock, Elin Bonnevier, Ebba Palenius, and Alice Dragomir
recurrence or PCSM (eg, men with adverse postsurgery pathology, pathologic T3 disease, increasing PSA levels, or positive surgical margins) in whom treatment amelioration/addition is suggested. Grouping of the interventions was based on published literature
Julia R. Trosman, Christine B. Weldon, R. Kate Kelley, and Kathryn A. Phillips
with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology . J Mol Diagn 2012 ; 14 : 525 – 540 . 15. Manolio TA Chisholm RL Ozenberger B . Implementing genomic medicine in the clinic: the future is
Marta Penas-Prado, Terri S. Armstrong, and Mark R. Gilbert
This was a hands-on multidisciplinary workshop in which clinicians, scientists, and advocacy partners met to discuss areas requiring further development, including understanding patients’ needs, deciphering the molecular pathology of adult
Nadeem R. Abu-Rustum
Grade and Depth of Myometrial Invasion Pathology A key component of the added value of SLN procedures in endometrial cancer is enhanced pathology, also known as ultrastaging . At the authors’ institution, the protocol for SLN evaluation is
