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Anastasia Tararykova, Alexander Fedenko, and Elmar Musaev

Background : Giant cell tumor of bone (GCT) is a relatively rare, locally aggressive osteolytic skeletal neoplasm of young adults with uncertain behavior with recurrence rates up to 70%. Distant metastases occur approximately 2-6% of cases most

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Benigno Emmanuel Rodriguez Soto, Lorena López Zepeda, Alejandro Noguez Ramos, Daniela Vázquez Juarez, Daniela Shveid Gerson, Yazmin Carolina Blanco Vázquez, Samuel Rivera Rivera, Alberto Villalobos Prieto, Gabriela Olivia Regalado Porras, Ivonne Salcedo Sullk, Fernando Pérez Zincer, Christian Patricio Camacho Limas, Juan Alberto Serrano Olvera, Álvaro Aguayo González, Guillermo Manuel Olivares Beltrán, and Raquel Gerson Cwilich

.014). The OR in PFS with HR, proliferation index, clinical stage or ECOG was not significant. Associating metastasis pattern and PFS, patients with lung metastases are at greater risk: OR:9.40 (95% CI 1.73-51.10, p=0.006), the other metastatic sites were not

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Douglas B. Johnson and Jeffrey A. Sosman

melanoma; staging PET/CT scan and brain MRI showed no disseminated metastases. He was treated with high-dose interferon alpha for 1 year, through mid-2012. One month later, he noted supraclavicular fullness and monocular blurred vision. CT scans showed a

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Aileen B. Chen, Jiangong Niu, Angel M. Cronin, Ya-Chen Tina Shih, Sharon Giordano, and Deborah Schrag

patients who were diagnosed with metastatic lung, breast, prostate, or colorectal cancer in 2010 through 2015 (AJCC 7th edition stage IV lung, breast, or colorectal cancer or stage IV prostate cancer with distant metastases) and who initiated RT within 1

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Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson III, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Anne Covey, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman Jr., Charles Fuchs, Jean L. Grem, Krystyna Kiel, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Sujata Rao, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, Constantinos Sofocleous, James Thomas, Alan P. Venook, and Christopher Willett

. 16 Newland RC Dent OF Lyttle MN . Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients . Cancer 1994 ; 73 : 2076 – 2082 . 17 Chapuis PH Dent OF

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Courtney Lawhn Heath, Laura J. Esserman, Robert R. Flavell, and Michelle E. Melisko

the growing consensus that 18 F-FDG PET/CT adds value to the care of locally advanced breast cancer. Retrospective and prospective evidence suggests that 18 F-FDG PET/CT detects unsuspected axillary and distant metastases in a sizable proportion of

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Pamela J. DiPiro

diagnosis, reported detection of true metastases in lung or liver in 1 (0.2%), 0 (0%), and 24 (6%) patients with stages I, II, and III disease, respectively. This study showed the lack of utility in obtaining routine chest CT at initial diagnosis in early

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Michael G. Milligan, Angel M. Cronin, Yolonda Colson, Kenneth Kehl, Debra N. Yeboa, Deborah Schrag, and Aileen B. Chen

Background The brain is a common site of metastasis for non–small cell lung cancer (NSCLC), and many patients undergo brain imaging with MRI or CT before definitive treatment. The hope is that early detection of brain metastases can expedite

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Daniel G. Coit, John A. Thompson, Alain Algazi, Robert Andtbacka, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Dominick DiMaio, Marc Ernstoff, Ryan C. Fields, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Richard W. Joseph, Julie R. Lange, Mary C. Martini, Miguel A. Materin, Anthony J. Olszanski, Merrick I. Ross, April K. Salama, Joseph Skitzki, Jeff Sosman, Susan M. Swetter, Kenneth K. Tanabe, Javier F. Torres-Roca, Vijay Trisal, Marshall M. Urist, Nicole McMillian, and Anita Engh

observation in 1256 patients with completely resected stage III melanoma (without distant or in-transit metastases). The pegylated IFN regimen included induction with 6 mcg/kg subcutaneously per week for 8 weeks followed by maintenance with 3 mcg

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Michael S. Sabel and Sandra L. Wong

Edited by Kerrin G. Robinson

– 923 . 23 Klein M Freedman N Lotem M . Contribution of whole body F-18-FDG-PET and lymphoscintigraphy to the assessment of regional and distant metastases in cutaneous malignant melanoma . Nuklearmedizin 2000 ; 39 : 56 – 61 . 24