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NCCN Guidelines® Insights: Prostate Cancer, Version 1.2023

Featured Updates to the NCCN Guidelines

Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Daniel Barocas, Rhonda Bitting, Alan Bryce, Brian Chapin, Heather H. Cheng, Anthony Victor D’Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. McKay, Todd Morgan, George Netto, Julio M. Pow-Sang, Robert Reiter, Mack Roach III, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Ryan A. Berardi, Dorothy A. Shead, and Deborah A. Freedman-Cass

therapies compared with those receiving only ADT and docetaxel. The populations receiving the triplet and doublet therapies experienced similar rates neutropenia, febrile neutropenia, fatigue, and neuropathy, although grade ≥3 adverse events occurred 63% of

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Incorporation of Crizotinib into the NCCN Guidelines

Gregory J. Riely, Jamie E. Chaft, Marc Ladanyi, and Mark G. Kris

using another test), treatment with crizotinib is recommended. The available data support the use of crizotinib in any line of therapy. 4 , 5 Moreover, the relatively well-tolerated nature of crizotinib (severe toxicities such as neutropenia are rare

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Optimization of Postremission Therapy in Follicular Lymphoma: Efficacy of Rituximab Maintenance

Rupali Roy and Leo I. Gordon

, diffuse alveolar hemorrhage, pulmonary cysts, and pulmonary hypertension. Few data exist regarding late toxicity from rituximab, but late-onset neutropenia (LON) has emerged. Rituximab-associated LON is defined by most investigators as grade III to IV

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Updates in Treatment Strategies for Hodgkin Lymphoma

Ranjana H. Advani

associated with a 5% improvement in modified PFS but also higher rates of febrile neutropenia and neuropathy. The FDA indication approval recommends growth factor support with BV‐AVD. 8 The other issue to consider with these regimens is cost. Because of the

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New Options for the Management of Castration-Resistant Prostate Cancer: A Case Perspective

Dawn Goetz

seen grade 3 or 4 adverse effects are neutropenia, febrile neutropenia, anemia, leukopenia, diarrhea, fatigue, and asthenia. The approximate neutrophil nadir is 12 days, and cabazitaxel carries a black box warning against giving the drug to patients

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Relapsed/Refractory CLL/SLL: Overcoming Resistance to Covalent BTKi and/or BCL2 Inhibitors

Presented by: Brian T. Hill

low rates of grade ≥3 bleeding (0.9%), contusions (0%), diarrhea (0.3%), and atrial fibrillation (0.3%). Neutropenia, although not infrequent, resulted in relatively low rates of grade ≥3 infection (∼4%), which was “noteworthy” in this heavily

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Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology

Apar Kishor P. Ganti, Billy W. Loo Jr., Michael Bassetti, Collin Blakely, Anne Chiang, Thomas A. D'Amico, Christopher D'Avella, Afshin Dowlati, Robert J. Downey, Martin Edelman, Charles Florsheim, Kathryn A. Gold, Jonathan W. Goldman, John C. Grecula, Christine Hann, Wade Iams, Puneeth Iyengar, Karen Kelly, Maya Khalil, Marianna Koczywas, Robert E. Merritt, Nisha Mohindra, Julian Molina, Cesar Moran, Saraswati Pokharel, Sonam Puri, Angel Qin, Chad Rusthoven, Jacob Sands, Rafael Santana-Davila, Michael Shafique, Saiama N. Waqar, Kristina M. Gregory, and Miranda Hughes

biopsies may be indicated in select patients with nucleated red blood cells on peripheral blood smear, neutropenia, or thrombocytopenia suggestive of bone marrow infiltration and with no other evidence of metastatic disease. Bone marrow involvement as the

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Part I: The Role of Maintenance Therapy in Patients With Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation

Philip L. McCarthy

the maintenance studies were primarily hematologic, especially neutropenia and, to a lesser extent, thrombocytopenia and anemia. 4 - 7 , 33 The role of maintenance therapy following induction therapy without AHSCT is discussed in detail in Part II by

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Part II: Role of Maintenance Therapy in Transplant-Ineligible Patients

Antonio Palumbo and Roberto Mina

%-59%). Neutropenia is one of the major toxicities associated with lenalidomide administration, and grade 3/4 events were reported in 7% of patients receiving lenalidomide continuously. In these patients, the rate of thrombocytopenia was 6%, and no extrahematologic

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A Population-Based Assessment of Emergency Department Observation Status for Older Adults With Cancer

Allison Lipitz-Snyderman, Adam Klotz, Renee L. Gennarelli, and Jeffrey Groeger

for oncologic emergencies are identified, such as evolving risk stratification paradigms for febrile neutropenia, observation status will likely play an increasing role. 20 The NCI has identified the management of oncologic emergencies as an important