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David M. Brizel, William Lydiatt, and A. Dimitrios Colevas

clinical equipoise exists with respect to various current and experimental treatment regimens. Surgery has historically been the workhorse of HNC treatment. Over the past 20 years, the treatment of OPC has been largely supplanted by radiation

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Robert W. Carlson, Susan Moench, Arti Hurria, Lodovico Balducci, Harold J. Burstein, Lori J. Goldstein, William J. Gradishar, Kevin S. Hughes, Mohammad Jahanzeb, Stuart M. Lichtman, Lawrence B. Marks, Joan S. McClure, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Mary Lou Smith, Neal S. Topham, Tiffany A. Traina, John H. Ward, and Eric P. Winer

older woman. A total of 18 task force members represented medical oncology, radiation oncology, surgical oncology, geriatric oncology, geriatrics, plastic surgery, and patient advocacy. All task force members were identified and invited solely by NCCN. A

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Frank Balis, Daniel M. Green, Clarke Anderson, Shelly Cook, Jasreman Dhillon, Kenneth Gow, Susan Hiniker, Rama Jasty-Rao, Chi Lin, Harold Lovvorn III, Iain MacEwan, Julian Martinez-Agosto, Elizabeth Mullen, Erin S. Murphy, Mark Ranalli, Daniel Rhee, Denise Rokitka, Elisabeth (Lisa) Tracy, Tamara Vern-Gross, Michael F. Walsh, Amy Walz, Jonathan Wickiser, Matthew Zapala, Ryan A. Berardi, and Miranda Hughes

presentations are found incidentally at surgery for another cause (eg, trauma, appendicitis). Most children present with a solitary tumor in one kidney. However, 5%–13% of children have bilateral tumors and 10% have multifocal tumors in a single kidney. Most

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

more effective treatment. 5 Treatment Approach The treatment of breast cancer includes the treatment of local disease with surgery, radiation therapy, or both, and systemic treatment with chemotherapy, endocrine therapy, biologic therapy, or

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Mei-Chin Hsieh, Lu Zhang, Xiao-Cheng Wu, Mary B. Davidson, Michelle Loch, and Vivien W. Chen

Effectiveness Research (CER) and the SEER registry. The CDC-CER registries reabstracted medical records and collected detailed and complete first-course treatment information, including type of surgery, radiation, and all systemic treatments, from all sources

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Jaffer A. Ajani, Thomas A. D’Amico, Khaldoun Almhanna, David J. Bentrem, Stephen Besh, Joseph Chao, Prajnan Das, Crystal Denlinger, Paul Fanta, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kory Jasperson, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, Stephen Leong, A. Craig Lockhart, Mary F. Mulcahy, Mark B. Orringer, James A. Posey, George A. Poultsides, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese Jr, Mary Kay Washington, Christopher G. Willett, Cameron D. Wright, Debra Zelman, Nicole McMillian, and Hema Sundar

complete and most recent version of these guidelines, visit NCCN.org ). Staging The TNM classification developed by the AJCC in 2002 was based on pathologic review of the surgical specimen in patients who underwent surgery as primary therapy. The

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Srinivas K. Tantravahi, and Theresa L. Werner

management of early-stage tumors and treatment failure with isolated local recurrence. In medically operable patients, total hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection is the recommended surgery for

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Armin Shahrokni, Bella Marie Vishnevsky, Brian Jang, Saman Sarraf, Koshy Alexander, Soo Jung Kim, Robert Downey, Anoushka Afonso, and Beatriz Korc-Grodzicki

Background For many cancers, surgery remains the primary curative treatment. 1 – 3 Geriatric patients experience increased rates of surgical complications compared with younger patients, leading to decreased long-term survival and delayed recovery

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Mandy R. Sakamoto, Megan Eguchi, Christine M. Azelby, Jennifer R. Diamond, Christine M. Fisher, Virginia F. Borges, Cathy J. Bradley, and Peter Kabos

prescribing opioids in patients with cancer focus on relieving acute pain or pain associated with advanced disease. 13 – 16 A recent study of patients with cancer undergoing curative-intent surgery found that 10.4% had new persistent opioid use at 1 year

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Stephen B. Edge and David G. Sheldon

findings from the National Surgical Adjuvant Breast Project (protocol 6). I. Intraductal carcinoma (DCIS) . Cancer 1986 ; 57 : 197 – 208 . 12 Solin LJ Kurtz J Fourquet A . Fifteen-year results of breast-conserving surgery and definitive