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Large-cell neuroendocrine carcinoma (LCNEC) is one of the most challenging diseases to diagnose in the practice of diagnostic surgical pathology, and is consequently challenging for oncologists to determine the best treatment. The knowledge of a

the physician to perform the procedure properly. Primary Treatment The primary tumor is assessed after surgery, and nodal surgical pathology drives treatment. Postoperative radiation is given to patients with node-positive disease. Radiation

studies in complex pathologies such as pancreatic adenocarcinoma is the potential lack of completeness of the pertinent imaging findings or use of inappropriate terminology that is not mutually understandable by all members of the treating team. This

HER2-negative (Group 2, HER2-negative). The panel suggested that pathology reports include the statement “evidence is limited on the efficacy of HER2-targeted therapy in the small subset of cases with a HER2 / CEP17 ratio of ≥2 and an average HER2

biopsy, followed by a left modified radical neck dissection and left total parotidectomy. Pathology from his surgical resection revealed a high-grade, locally advanced (pT4aN2b,cM0) SDC with multiple high-risk features, including a positive margin of

with TME. 8 , 9 If the pathology of the local excision specimen shows a high-risk T1 rectal cancer or if the tumor is ≥T2, the patient will have unacceptable, high recurrence rates (>15%) and possibly reduced survival without further treatment compared

. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology . Genet Med 2015 ; 17 : 405 – 424 . 22

breast revealed 7 cm of multifocal IDC, grade 2, and 7 cm of intermediate-grade DCIS, 0.1 cm from the deep margin. One of 17 lymph nodes was involved, measuring 1.6 cm with extranodal extension. Pathology of the left breast showed 3 foci of IDC

pathology protocol to examine a TME specimen was introduced in the 1990s, related to the start of the Dutch TME trial. 5 Because of this standardization, 97% of patients included in this trial had a reported CRM. 2 In subsequent years, until the start of

demonstrated a paralyzed left vocal cord. The patient underwent an attempt at left thyroidectomy with tumor resection that also involved the esophagus and jugular vein, and a limited left neck dissection. Pathology was consistent with anaplastic