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Oncology Research Program

, but in the advanced setting can be very disabling and can impact quality of life (QOL) due to diarrhea, bowel obstructions, pain, weight loss, depression, and fatigue. Many of the abdominal symptoms are caused by the dense adhesions. Midgut carcinoids

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REMS. The table below reflects a sample of drugs recently added that may be used for a supportive care indication (e.g., pain, cancer-related fatigue) in a patient with cancer. All the drugs listed require the provision of a medication guide detailing

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Implementing Routine Screening for Distress, the Sixth Vital Sign, for Patients With Head and Neck and Neurologic Cancers

Barry D. Bultz, Amy Waller, Jodi Cullum, Paula Jones, Johan Halland, Shannon L. Groff, Catriona Leckie, Lisa Shirt, Scott Blanchard, Harold Lau, Jacob Easaw, Konrad Fassbender, and Linda E. Carlson

integrated into regular clinical practice and run by frontline clinic staff. Screening was linked with follow-up care and services, including psychosocial resources, pain and fatigue clinics, nutrition services, and palliative care, using referral guidelines

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Development and Validation of 11 Symptom Indexes to Evaluate Response to Chemotherapy for Advanced Cancer

David Cella, Sarah K. Rosenbloom, Jennifer L. Beaumont, Susan E. Yount, Diane Paul, Debra Hampton, Amy P. Abernethy, Paul B. Jacobsen, Karen Syrjala, and Jamie H. Von Roenn

symptoms specific to a given tumor can represent efficacy in achieving a meaningful patient outcome. Most validated measures of cancer-specific quality of life incorporate an assessment of certain prevalent symptoms, such as pain and fatigue, within a

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Prostate Cancer, Version 4.2023, NCCN Clinical Practice Guidelines in Oncology

Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Daniel Barocas, Rhonda Bitting, Alan Bryce, Brian Chapin, Heather H. Cheng, Anthony Victor D’Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. McKay, Todd Morgan, George Netto, Julio M. Pow-Sang, Robert Reiter, Mack Roach III, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Dorothy A. Shead, Jenna Snedeker, and Deborah A. Freedman-Cass

nature and largely related to mineralocorticoid excess (ie, hypertension, hypokalemia, edema), hormonal effects (ie, fatigue, hot flushes), and liver toxicity. 13 Cardiac events, such as atrial fibrillation, were rare but slightly increased with

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NCCN Guidelines® Insights: Older Adult Oncology, Version 1.2021

Featured Updates to the NCCN Guidelines

Efrat Dotan, Louise C. Walter, Ilene S. Browner, Katherine Clifton, Harvey Jay Cohen, Martine Extermann, Cary Gross, Sumati Gupta, Genevieve Hollis, Joleen Hubbard, Reshma Jagsi, Nancy L. Keating, Elizabeth Kessler, Thuy Koll, Beatriz Korc-Grodzicki, June M. McKoy, Sumi Misra, Dominic Moon, Tracey O’Connor, Cynthia Owusu, Ashley Rosko, Marcia Russell, Mina Sedrak, Fareeha Siddiqui, Amy Stella, Derek L. Stirewalt, Ishwaria M. Subbiah, William P. Tew, Grant R. Williams, Liz Hollinger, Giby V. George, and Hema Sundar

confounded by fatigue, depression, anxiety, underlying brain tumors, endocrine dysfunction, nutritional deficiency, alcohol use, and sleep disturbances. 50 Therefore, if dementia is suspected, further evaluation including brain imaging, neuropsychological

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Everolimus Causing Severe Hypertriglyceridemia and Acute Pancreatitis

Somasundaram Subramaniam, Jason A. Zell, and Pamela L. Kunz

therefore initiated therapy with everolimus. After starting everolimus he noted improvement in pain and diarrhea. He had side effects of fatigue, stomatitis, a pustular rash on his fingers and scalp, and mild thrombocytopenia. He had been on everolimus for

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Immunotherapy for Lung Cancer: Many Questions Yet to Be Answered

David S. Ettinger

%, respectively. The most common side effects of nivolumab were fatigue, musculoskeletal pain, decreased appetite, cough, and constipation. Eighty-three patients had tumor samples suitable for PD-L1 expression analysis. Across the prespecified expression levels

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New Treatment Options in Castration-Resistant Prostate Cancer

Andrew J. Armstrong

men that were evaluated,” explained Dr. Armstrong. Fatigue, fall risk, and hypertension were the most common clinically relevant adverse events associated with enzalutamide treatment. 7 In fact, hypertension occurred 2 to 3 times as often with

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Optimal Treatment of Unresectable Nonmelanoma Skin Cancers

Thomas Olencki

SCC. A phase II study was conducted at his center, but was discontinued due to overwhelming fatigue, anorexia, weight loss, and pleural effusion. Other therapies appear to offer more promise in the treatment of cutaneous SCC. Dr. Olencki discussed