. In addition, agents with antiangiogenic properties have shown single-agent activity in this disease. Sorafenib has been shown to have a 14% response rate in patients with previously treated angiosarcomas in the phase II setting. Bevacizumab has
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antiangiogenic agent. In addition, agents with antiangiogenic properties have shown single-agent activity in this disease. Sorafenib has been shown to have a 14% response rate in angiosarcomas in previously treated patients in the phase II setting. Bevacizumab
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a phase II randomized trial for patients with lung cancer. The study is titled TH-138: Phase II Randomized Trial of Carboplatin + Pemetrexed + Bevacizumab, With or Without Atezolizumab in Stage IV Non-Squamous NSCLC Patients Who Harbor a Sensitizing
Oncology Research Program
addition, agents with antiangiogenic properties have shown single-agent activity in this disease. Sorafenib has been shown to have a 14% response rate in angiosarcomas in previously treated patients in the phase II setting. Bevacizumab has demonstrated a 12
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and risks and discuss them thoroughly with their physician.” Dr. Morgan discussed 2 additional phase III trials assessing bevacizumab (Avastin, Genentech/Roche) combined with carboplatin/paclitaxel in the upfront setting compared with carboplatin
Systemic Therapy for Advanced Carcinoid Tumors: Where Do We Go From Here?
A. Scott Paulson and Emily K. Bergsland
strategy remains controversial, and is typically reserved for patients with SSTa-resistant disease. 11 , 14 , 29 Notably, treatment with interferon is the control arm for an ongoing randomized phase III study exploring the use of bevacizumab in patients on
Chemotherapy With or Without Anti-EGFR Agents in Left- and Right-Sided Metastatic Colorectal Cancer: An Updated Meta-Analysis
Zi-Xian Wang, Hao-Xiang Wu, Ming-Ming He, Ying-Nan Wang, Hui-Yan Luo, Pei-Rong Ding, Dan Xie, Gong Chen, Yu-Hong Li, Feng Wang, and Rui-Hua Xu
efficacy of chemotherapy + cetuximab (Cet) or panitumumab (Pani) versus chemotherapy ± bevacizumab (Bev) reported significant improvement in overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) with chemotherapy + Cet
Non–Clear Cell Renal Cancer: Features and Medical Management
Daniel Y. C. Heng and Toni K. Choueiri
; 356 : 125 – 134 . 16 Escudier B Koralewski P Pluzanska A . A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon- α2a as first-line therapy in metastatic renal cell carcinoma
Kidney Cancer, Version 2.2014
Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Ithaar H. Derweesh, Shilpa Gupta, Steven L. Hancock, Jenny J. Kim, Timothy M. Kuzel, Elaine T. Lam, Clayton Lau, Ellis G. Levine, Daniel W. Lin, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Elizabeth R. Plimack, Edward N. Rampersaud, Bruce G. Redman, Charles J. Ryan, Joel Sheinfeld, Kanishka Sircar, Brad Somer, Jue Wang, Richard B. Wilder, Mary A. Dwyer, and Rashmi Kumar
least 6 weeks, or confirmed partial response or complete response using RECIST was 64%. The median OS was 27 months. 27 Other Therapies for Patients With Non-Clear Cell Carcinomas Bevacizumab is a humanized monoclonal antibody that binds and
Rationing Cancer Care: A Survey Among the Members of the German Society of Hematology and Oncology
Stefan W. Krause, Jan Schildmann, Christian Lotze, and Eva C. Winkler
given examples of treatments withheld on the grounds of unconvincing evidence and based on an unfavorable cost/benefit analysis were erlotinib, bevacizumab, and other antibodies ( Table 3 , Q5 and Q7). Typical examples for withholding treatments because
