some patients with disease at lower risk of local recurrence (eg, proximal rectal cancer staged as T3,N0,M0, characterized by clear margins and favorable prognostic features) may be adequately treated with surgery and adjuvant chemotherapy. 38 , 109
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Al B. Benson III, Tanios Bekaii-Saab, Emily Chan, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Paul F. Engstrom, Peter C. Enzinger, Marwan G. Fakih, Charles S. Fuchs, Jean L. Grem, Steven Hunt, Lucille A. Leong, Edward Lin, Michael G. Martin, Kilian Salerno May, Mary F. Mulcahy, Kate Murphy, Eric Rohren, David P. Ryan, Leonard Saltz, Sunil Sharma, David Shibata, John M. Skibber, William Small Jr, Constantinos T. Sofocleous, Alan P. Venook, Christopher G. Willett, Deborah A. Freedman-Cass, and Kristina M. Gregory
Margaret von Mehren, R. Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ernest U. Conrad III, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, John M. Kane III, Henry Koon, Joel Mayerson, Martin McCarter, Sean V. McGarry, Christian Meyer, Richard J. O'Donnell, Alberto S. Pappo, I. Benjamin Paz, Ivy A. Petersen, John D. Pfeifer, Richard F. Riedel, Scott Schuetze, Karen D. Schupak, Herbert S. Schwartz, William D. Tap, Jeffrey D. Wayne, Mary Anne Bergman, and Jillian Scavone
Postoperative doxorubicin-based chemotherapy was associated with improved RFS in male patients and those older than 40 years, although female patients and those 40 years or younger who received adjuvant chemotherapy had marginally worse OS. However, RFS and OS
Al B. Benson III, Michael I. D’Angelica, Thomas A. Abrams, Chandrakanth Are, P. Mark Bloomston, Daniel T. Chang, Bryan M. Clary, Anne M. Covey, William D. Ensminger, Renuka Iyer, R. Kate Kelley, David Linehan, Mokenge P. Malafa, Steven G. Meranze, James O. Park, Timothy Pawlik, James A. Posey, Courtney Scaife, Tracey Schefter, Elin R. Sigurdson, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Yun Yen, Andrew X. Zhu, Karin G. Hoffmann, Nicole R. McMillian, and Hema Sundar
gemcitabine chemotherapy as options for adjuvant treatment. See “Adjuvant Chemotherapy and Chemoradiation for Biliary Tract Cancers,” page 1172. Management of Unresectable or Metastatic Disease Preoperative evaluation and a biopsy to confirm the
Rodger J. Winn
. Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women . Ann Intern Med 2003 ; 138 : 90 – 97 . 12 Bloom BJ de Pourourville N Chhatre S . Breast cancer treatment in clinical practice compared to
Gregory P. Kalemkerian
thoracic surgery community, the primary additions to the literature have been retrospective reviews of institutional or registry data. That said, both Schneider et al. and the NCCN Guidelines Panel for SCLC agree that surgery followed by adjuvant
Steven M. Grunberg
effect of a consensus statement on the practice of physicians . N Engl J Med 1989 ; 321 : 1306 – 1311 . 26 Drug Utilization Review Team in Oncology . Antiemetic prescription in Italian breast cancer patients submitted to adjuvant
Robert J. Downey and Lee M. Krug
. Ann Thorac Surg 1992 ; 54 : 498 – 501 . 12 Coolen L Van den Eeckhout A Deneffe G . Surgical treatment of small cell lung cancer . Eur J Cardio-Thorac Surg 1995 ; 9 : 59 – 64 . 13 Shepherd FA Evans WK Feld R . Adjuvant
Mary F. Mulcahy, Andrew O. Wahl, and William Small Jr.
III trial of adjuvant chemotherapy with gemcitabine vs. observation in patients with resected pancreatic cancer . J Clin Oncol 2005 ; 23 ( suppl ): 1092S . 5 Tepper J Nardi G Sutt H . Carcinoma of the pancreas: review of MGH experience
Sherif R. Z. Abdel-Misih, Lai Wei, Al B. Benson III, Steven Cohen, Lily Lai, John Skibber, Neal Wilkinson, Martin Weiser, Deborah Schrag, and Tanios Bekaii-Saab
chemotherapy after preoperative therapy for rectal cancer. 23 This study concluded that adjuvant chemotherapy demonstrated no statistically significant improvement in disease-free survival or OS in patients after neoadjuvant treatment. This naturally prompts
Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Brian A. Costello, Ithaar H. Derweesh, Shilpa Gupta, Steven L. Hancock, Jenny J. Kim, Timothy M. Kuzel, Elaine T. Lam, Clayton Lau, Ellis G. Levine, Daniel W. Lin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Elizabeth R. Plimack, Edward N. Rampersaud, Bruce G. Redman, Charles J. Ryan, Joel Sheinfeld, Brian Shuch, Kanishka Sircar, Brad Somer, Richard B. Wilder, Mary Dwyer, and Rashmi Kumar
associated with an increased risk of cancer and heart disease. However, if adjuvant chemotherapy is chosen, the NCCN Guidelines for Testicular Cancer recommend carboplatin AUC × 7 for either 1 or 2 cycles as a category 2A recommendation for patients with
