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NCCN Task Force Report: Positron Emission Tomography (PET)/Computed Tomography (CT) Scanning in Cancer

Donald A. Podoloff, Ranjana H. Advani, Craig Allred, Al B. Benson III, Elizabeth Brown, Harold J. Burstein, Robert W. Carlson, R. Edward Coleman, Myron S. Czuczman, Dominique Delbeke, Stephen B. Edge, David S. Ettinger, Frederic W. Grannis Jr., Bruce E. Hillner, John M. Hoffman, Krystyna Kiel, Ritsuko Komaki, Steven M. Larson, David A. Mankoff, Kenneth E. Rosenzweig, John M. Skibber, Joachim Yahalom, JQ Michael Yu, and Andrew D. Zelenetz

rate of these patients was 44% compared with 96.8% among the other patients. Mankoff et al. 25 also evaluated patients with locally advanced breast cancer to determine whether the results of PET predicted response to neoadjuvant chemotherapy. In this

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Trimodal Therapy Approaches for Localized Rectal Cancer

Presented by: Christopher G. Willett

issue in assessing the relative merits of these 2 approaches,” Dr. Willett said. The more recent Polish II trial was similar to TROG 01.04 but incorporated neoadjuvant chemotherapy with 4 cycles of FOLFOX (5-FU/leucovorin/oxaliplatin) after SCRT prior to

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Updates in the Treatment of Metastatic Colorectal Cancer

Presented by: Midhun Malla, Katrina S. Pedersen, and Aparna R. Parikh

needed to address optimal dosing, scheduling, and survival outcomes in Western populations.” Neoadjuvant Chemotherapy: MSI-H Colon Cancer As Dr. Pedersen reported, the recently released NCCN Guidelines for Colon Cancer have undergone significant

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Colon Cancer

Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson III, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Anne Covey, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman Jr., Charles Fuchs, Jean L. Grem, Krystyna Kiel, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Sujata Rao, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, Constantinos Sofocleous, James Thomas, Alan P. Venook, and Christopher Willett

metastases . Eur J Cancer 2006 ; 42 : 2212 – 2221 . 94 Yoo PS Lopez-Soler RI Longo WE Cha CH . Liver resection for metastatic colorectal cancer in the age of neoadjuvant chemotherapy and bevacizumab . Clin Colorectal Cancer 2006 ; 6 : 202

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Analysis of Circulating Tumor Cells in Breast Cancer

Zeynep Eroglu, Odicie Fielder, and George Somlo

initiating neoadjuvant chemotherapy adversely affected distant metastasis-free and overall survivals. 21 , 22 In a meta-analysis of 49 studies enrolling 6825 patients in both early-stage and metastatic breast cancer settings, 23 the presence of CTCs in

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Breast Cancer Version 3.2014

William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

. 60 Preoperative Systemic Therapy in Patients With HER2 + Tumors: In women with HER2 + tumors treated with neoadjuvant chemotherapy, the addition of neoadjuvant trastuzumab to paclitaxel followed by chemotherapy with FEC (fluorouracil

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NCCN Guidelines Insights: Rectal Cancer, Version 6.2020

Featured Updates to the NCCN Guidelines

Al B. Benson III, Alan P. Venook, Mahmoud M. Al-Hawary, Mustafa A. Arain, Yi-Jen Chen, Kristen K. Ciombor, Stacey Cohen, Harry S. Cooper, Dustin Deming, Ignacio Garrido-Laguna, Jean L. Grem, Andrew Gunn, Sarah Hoffe, Joleen Hubbard, Steven Hunt, Natalie Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Jeffrey Meyerhardt, Eric D. Miller, Mary F. Mulcahy, Steven Nurkin, Michael J. Overman, Aparna Parikh, Hitendra Patel, Katrina Pedersen, Leonard Saltz, Charles Schneider, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Elena M. Stoffel, Eden Stotsky-Himelfarb, Christopher G. Willett, Alyse Johnson-Chilla, and Lisa A. Gurski

C , . Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer . J Natl Compr Canc Netw 2014 ; 12 : 513 – 519 . 24717570 10.6004/jnccn.2014.0056 17. Chau I , Brown G

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Impact of Recombinant Granulocyte Colony-Stimulating Factor During Neoadjuvant Therapy on Outcomes of Resected Pancreatic Cancer

Pranav Murthy, Mazen S. Zenati, Samer S. AlMasri, Annissa DeSilva, Aatur D. Singhi, Alessandro Paniccia, Kenneth K. Lee, Richard L. Simmons, Nathan Bahary, Michael T. Lotze, and Amer H. Zureikat

treatment protocols may help to identify incremental yet important improvements in clinical outcomes. Neoadjuvant chemotherapy has been increasingly used in the treatment of patients with resectable and borderline resectable PDAC, but little is known about

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Surgery After Response to Chemotherapy for Locally Advanced Pancreatic Ductal Adenocarcinoma: A Guide for Management

Zhi Ven Fong and Cristina R. Ferrone

after the resection are devastating complications from this operation. Truty et al 47 recently reported outcomes of pancreatectomy with en bloc celiac axis resection among 90 patients with PDAC, of whom 89% had received neoadjuvant chemotherapy. The

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NCCN Guidelines Insights: Bladder Cancer, Version 5.2018

Thomas W. Flaig, Philippe E. Spiess, Neeraj Agarwal, Rick Bangs, Stephen A. Boorjian, Mark K. Buyyounouski, Tracy M. Downs, Jason A. Efstathiou, Terence Friedlander, Richard E. Greenberg, Khurshid A. Guru, Noah Hahn, Harry W. Herr, Christopher Hoimes, Brant A. Inman, Masahito Jimbo, A. Karim Kader, Subodh M. Lele, Joshua J. Meeks, Jeff Michalski, Jeffrey S. Montgomery, Lance C. Pagliaro, Sumanta K. Pal, Anthony Patterson, Daniel P. Petrylak, Elizabeth R. Plimack, Kamal S. Pohar, Michael P. Porter, Mark A. Preston, Wade J. Sexton, Arlene O. Siefker-Radtke, Jonathan Tward, Geoffrey Wile, Alyse Johnson-Chilla, Mary A. Dwyer, and Lisa A. Gurski

chemotherapy and radical cystectomy . J Urol 2016 ; 195 : 53 – 59 . 14. Grossman HB Natale RB Tangen CM . Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer . N Engl J Med 2003 ; 349 : 859 – 866