-conserving surgery plus radiation therapy in DCIS are available. Several studies compare local excision to local excision plus whole-breast radiation (with or without tamoxifen), 9 and all showed improved local control with the addition of whole-breast radiation
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Real Personalized Medicine
James O. Armitage, William C. Wood, and Dan L. Longo
HER2-Mutated Breast Cancer Responds to Treatment With Single-Agent Neratinib, a Second-Generation HER2/EGFR Tyrosine Kinase Inhibitor
Noa Efrat Ben-Baruch, Ron Bose, Shyam M. Kavuri, Cynthia X. Ma, and Matthew J. Ellis
metastases were diagnosed and changing from letrozole to tamoxifen produced disease stabilization. In May 2011, massive hepatic progression was noted, with obstructive jaundice, ascites, and pleural effusion. Treatment with capecitabine and intensive
NCCN Bone Health Task Force: Key Recommendations
Azeez Farooki
, exemestane, and letrozole) have been shown to increase the risk of fracture compared with tamoxifen. Osteoporotic fracture is a concern in men, because up to 25% of men older than 50 suffer one, he added. ADT appears to increase the risk of fracture in men
Rational Use of Cytotoxic Chemotherapy for Recurrent Ovarian Cancer
Joyce Liu and Ursula Matulonis
Carrasco EM . Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: systematic review of the literature and implications for future research . Gynecol Oncol 2002 ; 84 : 201 – 209 . 45. del Carmen MG Fuller AF Matulonis
Taxanes in the Adjuvant Treatment of Breast Cancer
Donna Trauth and Lori J. Goldstein
. Effects of radiotherapy and surgery in early breast cancer – An overview of the randomized trials . N Engl J Med 1995 ; 333 : 1444 – 1456 . 2 Early Breast Cancer Trialists'Collaborative Group . Effects of adjuvant tamoxifen and of cytotoxic
Mortality After Invasive Second Breast Cancers Following Prior Radiotherapy for DCIS
Puyao C. Li, Zilu Zhang, Angel M. Cronin, and Rinaa S. Punglia
the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group . J Clin Oncol 2006 ; 24 : 3381 – 3387 . 16801628 2. Houghton J , George WD , Cuzick J , . Radiotherapy and tamoxifen in women with completely excised ductal carcinoma
Orally Administered Cancer Therapy: Breaking Down Barriers to Adherence and Quality of Life
Julia C. Shih and Anthony J. Olszanski
. 6 Within cancer care, the earliest reports of nonadherence rates were documented in breast cancer with endocrine therapies, ranging from 12% to 59% with tamoxifen and 9% to 50% with aromatase inhibitors. 7 In a systematic review by Greer et al, 1
Advances in the Management of Metastatic Breast Cancer
Presented by: William J. Gradishar
elacestrant (a selective estrogen receptor degrader) to the NCCN Guidelines offers another treatment option for patients with ESR mutations. 4 “While the traditional endocrine therapies, such as aromatase inhibitors, tamoxifen, and fulvestrant, have shown
Adoption of Gene Expression Profiling for Breast Cancer in US Oncology Practice for Women Younger Than 65 Years
Suzanne C. O'Neill, Claudine Isaacs, Calvin Chao, Huei-Ting Tsai, Chunfu Liu, Bola F. Ekezue, Nandini Selvam, Larry G. Kessler, Marc D. Schwartz, Tania Lobo, and Arnold L. Potosky
Cuzick J Wale C . Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study . J Clin Oncol 2010
Routine Use of Zoledronic Acid in Early-Stage Breast Cancer
Kathleen Harnden and Kimberly Blackwell
%) received chemotherapy. In both Z-FAST and ZO-FAST, patients were concurrently treated with letrozole. In ABCSG-12, patients were treated with ovarian suppression and either anastrozole or tamoxifen. The AZURE patients were on a variety of standard adjuvant
