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Michael A. Cilento, Nicola K. Poplawski, Sellvakumaram Paramasivam, David M. Thomas, and Ganessan Kichenadasse

omental caking. CA-125 serum tumor marker at time of presentation was elevated at 1,155 kU/L (normal range, <35 kU/L). The patient underwent primary surgery with radical hysterectomy, bilateral salpingo-oophorectomy, lymph node dissection, and removal of

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John J. Stocking, Michael V. Fiandalo, Elena A. Pop, John H. Wilton, Gissou Azabdaftari, and James L. Mohler

extrafascial radical prostatectomy, and right pelvic lymph node dissection revealed Gleason grade 3+4=7 adenocarcinoma that occupied 5% of a 20-gram prostate. Gleason grade was overestimated due to prostate biopsy undersampling, which occurs rarely. 9

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Daniel G. Coit, John A. Thompson, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Adil Daud, Dominick DiMaio, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Mary C. Martini, Anthony J. Olszanski, Merrick I. Ross, April Salama, Susan M. Swetter, Kenneth K. Tanabe, Vijay Trisal, Marshall M. Urist, Nicole R. McMillian, and Maria Ho

as an isolated site of relapse underwent therapeutic lymph node dissection followed by either adjuvant radiation to the nodal basin or observation. 5 Eligible patients were required to have a lactate dehydrogenase (LDH) level less than 1.5 times the

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Michelle T. Ashworth and Adil Daud

chest, abdomen, and pelvis identified no other lesions, and results of a complete right inguinal lymph node dissection were negative. The patient was treated with adjuvant radiotherapy (XRT), complicated by a nonhealing ulcer for 1 year and persistent

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Virginia G. Kaklamani and William J. Gradishar

, palpable, biopsy-proven early-stage breast cancer were randomized to receive either surgery (lumpectomy and axillary lymph node dissection or modified radical mastectomy) followed by 4 cycles of doxorubicin (60 mg/m 2 ) and cyclophosphamide (600 mg/m 2

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James Mohler, Robert R. Bahnson, Barry Boston, J. Erik Busby, Anthony D'Amico, James A. Eastham, Charles A. Enke, Daniel George, Eric Mark Horwitz, Robert P. Huben, Philip Kantoff, Mark Kawachi, Michael Kuettel, Paul H. Lange, Gary MacVicar, Elizabeth R. Plimack, Julio M. Pow-Sang, Mack Roach III, Eric Rohren, Bruce J. Roth, Dennis C. Shrieve, Matthew R. Smith, Sandy Srinivas, Przemyslaw Twardowski, and Patrick C. Walsh

decision-making for men contemplating active surveillance, 12 radical prostatectomy, 13 – 15 neurovascular bundle preservation, 16 – 18 or omission of pelvic lymph node dissection (PLND) during radical prostatectomy, 19 brachytherapy, 13 , 20 , 21 or

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Britt-Marie Ljung, David A. Mankoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Jasgit Sachdev, Mary Lou Smith, George Somlo, John H. Ward, Antonio C. Wolff, and Richard Zellars

pregnant during breast cancer treatment (see page 160). Locoregional Treatment Several randomized trials document that mastectomy with axillary lymph node dissection is equivalent to breast-conserving therapy with lumpectomy, axillary dissection

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Linda A. Jacobs and David J. Vaughn

the most commonly used treatment regimens. At the completion of treatment, an assessment of response and the need for postchemotherapy surgery (e.g., a retroperitoneal lymph node dissection [RPLND]) is assessed. Radiation therapy is another treatment

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Lyndsay J. Willmott, Daniele A. Sumner, and Bradley J. Monk

treatment protocol is surgical resection, typically with radical hysterectomy and pelvic lymph node dissection. Cure rates are good in this instance. However, more advanced disease is a greater challenge to treat effectively. The American Cancer Society

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David D. Buethe and Julio Pow-Sang

RP and pelvic lymph node dissection. Other reports confirm this observation. 17 , 23 , 28 Inspection of whole-mount prostatectomy specimens has previously shown a significant indirect correlation between percent-free PSA and prostate cancer volume