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the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group . J Clin Oncol 2006 ; 24 : 3381 – 3387 . 16801628 2. Houghton J , George WD , Cuzick J , . Radiotherapy and tamoxifen in women with completely excised ductal carcinoma

Carrasco EM . Tamoxifen therapy for ovarian cancer in the adjuvant and advanced settings: systematic review of the literature and implications for future research . Gynecol Oncol 2002 ; 84 : 201 – 209 . 45. del Carmen MG Fuller AF Matulonis

, exemestane, and letrozole) have been shown to increase the risk of fracture compared with tamoxifen. Osteoporotic fracture is a concern in men, because up to 25% of men older than 50 suffer one, he added. ADT appears to increase the risk of fracture in men

cancer mortality is not known. Other factors, such as venous stasis from vessel compression, immobility, central venous catheters (CVC), and thrombogenic anticancer therapies, such as tamoxifen and thalidomide, play a role in some patients. The new agents

. 6 Within cancer care, the earliest reports of nonadherence rates were documented in breast cancer with endocrine therapies, ranging from 12% to 59% with tamoxifen and 9% to 50% with aromatase inhibitors. 7 In a systematic review by Greer et al, 1

%) received chemotherapy. In both Z-FAST and ZO-FAST, patients were concurrently treated with letrozole. In ABCSG-12, patients were treated with ovarian suppression and either anastrozole or tamoxifen. The AZURE patients were on a variety of standard adjuvant

women who are BRCA -positive. 6 Retrospective studies of BRCA carriers indicate that adjuvant tamoxifen 7 and risk-reduction mastectomy can significantly reduce the risk for new primary breast cancer, up to 50% and 90%, respectively. 8 Risk

Cuzick J Wale C . Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: a TransATAC study . J Clin Oncol 2010

subtypes are a key determinant. Clinical trials have demonstrated that patients with HR+ (ER+ and/or PR+) breast cancer benefit from tamoxifen, those with HR– (ER– and PR–) benefit from adjuvant chemotherapy, and those with HER2+ disease benefit from

. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer . N Engl J Med 2004 ; 351 : 971 – 977 . 11. Hughes KS Schnaper LA Bellon JR . Lumpectomy plus tamoxifen with or without irradiation