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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Mohammad Jahanzeb, Krystyna Kiel, Britt-Marie Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Elizabeth C. Reed, Mary Lou Smith, George Somlo, Richard L. Theriault, Neal S. Topham, John H. Ward, Eric P. Winer, and Antonio C. Wolff

trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer . J Clin Oncol 2005 ; 23 : 3676 – 3685 . 94 Smith IE Dowsett M Ebbs SR . Neoadjuvant

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Keith D. Eaton and Renato G. Martins

the NCIC trial had a median survival of 7.4 months, although it was 7.9 months for patients enrolled on ECOG 1594, a trial comparing 3 third-generation doublets with cisplatin and paclitaxel published 14 years later. 2 Several strategies have

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Jonathan W. Riess, Seema Nagpal, Joel W. Neal, and Heather A. Wakelee

EGFR-activating mutation or an ALK translocation is doublet chemotherapy (category 1). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non–Small Cell Lung Cancer (NSCLC) currently list docetaxel, paclitaxel, pemetrexed, vinorelbine

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Apar Kishor Ganti, Mollie deShazo, Alva B. Weir III, and Arti Hurria

compared a combination of carboplatin and paclitaxel with single-agent chemotherapy (either gemcitabine or vinorelbine) in patients between ages 70 and 89 years. 43 In this study, median overall survival was better in the doublet arm, with a 4-month

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Nadeem Abu-Rustum, Catheryn Yashar, Rebecca Arend, Emma Barber, Kristin Bradley, Rebecca Brooks, Susana M. Campos, Junzo Chino, Hye Sook Chon, Christina Chu, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Robert Giuntoli II, Ernest Han, Jordan Holmes, Brooke E. Howitt, Jayanthi Lea, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Mirna Podoll, Ritu Salani, John Schorge, Jean Siedel, Rachel Sisodia, Pamela Soliman, Stefanie Ueda, Renata Urban, Stephanie L. Wethington, Emily Wyse, Kristine Zanotti, Nicole R. McMillian, and Shaili Aggarwal

alone. OS was comparable in both arms. 213 The GOG 249 trial examined vaginal cuff brachytherapy and 3 cycles of carboplatin/paclitaxel therapy (3 cycles) versus pelvic EBRT only in patients with high-risk, uterine-confined endometrial carcinoma (n=601

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Jaffer A. Ajani, Thomas A. D’Amico, Khaldoun Almhanna, David J. Bentrem, Stephen Besh, Joseph Chao, Prajnan Das, Crystal Denlinger, Paul Fanta, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kory Jasperson, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, Stephen Leong, A. Craig Lockhart, Mary F. Mulcahy, Mark B. Orringer, James A. Posey, George A. Poultsides, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese Jr, Mary Kay Washington, Christopher G. Willett, Cameron D. Wright, Debra Zelman, Nicole McMillian, and Hema Sundar

follow-up of 18 months, median OS time was 23 months. 42 The rate of locoregional progression-free survival (PFS), PFS, and 3-year OS rates were 60%, 29%, and 37%, respectively. Definitive chemoradiation with carboplatin and paclitaxel was also well

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Jeffrey Allen and Mohammad Jahanzeb

Edited by Kerrin G. Robinson

gemcitabine plus cisplatin as induction chemotherapy for stage III non-small cell lung cancer . Lung Cancer 2002 ; 35 : 319 – 327 . 20. De Marinis F Nelli F Migliorino MR . Gemcitabine, paclitaxel, and cisplatin as induction chemotherapy for

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Thomas W. Flaig

presented at the 2018 Genitourinary Cancers Symposium. This trial of 542 patients compared pembrolizumab (200 mg every 3 weeks) with chemotherapy (vinflunine, paclitaxel, or docetaxel). 6 , 7 The overall response rates were higher with pembrolizumab than

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David S. Ettinger, Mark Agulnik, Justin M. M. Cates, Mihaela Cristea, Crystal S. Denlinger, Keith D. Eaton, Panagiotis M. Fidias, David Gierada, Jon P. Gockerman, Charles R. Handorf, Renuka Iyer, Renato Lenzi, John Phay, Asif Rashid, Leonard Saltz, Lawrence N. Shulman, Jeffrey B. Smerage, Gauri R. Varadhachary, Jonathan S. Zager, and Weining (Ken) Zhen

carboplatin, gemcitabine, and paclitaxel followed by weekly paclitaxel was active and tolerable for patients with occult primary tumors and poor prognostic features. 59 Recently, Hainsworth et al. 63 , 64 reported that the combination of bevacizumab and

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William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

. 60 Preoperative Systemic Therapy in Patients With HER2 + Tumors: In women with HER2 + tumors treated with neoadjuvant chemotherapy, the addition of neoadjuvant trastuzumab to paclitaxel followed by chemotherapy with FEC (fluorouracil