colon masses. At total colectomy, the most advanced lesion was stage IIB. Pathology was notable for tumor-infiltrating lymphocytes (TILs) and the absence of MLH1 and PMS2 staining on immunohistochemistry ( Figure 1A ). Germline genetic testing revealed a
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Agata A. Bielska, Walid K. Chatila, Henry Walch, Nikolaus Schultz, Zsofia K. Stadler, Jinru Shia, Diane Reidy-Lagunes, and Rona Yaeger
Vivek Subbiah and Kanishka Sircar
using a commercially available assay for mutational assessment of 5 diagnostic microsatellite sequences; a pathology specimen is noted as MSI-H if at least 2 of 5 microsatellites harbor mutations. NGS or immunohistochemistry for MMR proteins may be also
Lindsey M. Charo, Adam M. Burgoyne, Paul T. Fanta, Hitendra Patel, Juliann Chmielecki, Jason K. Sicklick, and Michael T. McHale
. Risk of recurrence is determined by tumor size, location, mitotic rate, and tumor rupture. Prediction tools, such as the modified NIH method, 8 the Armed Forces Institute of Pathology (AFIP; Miettinen criteria), 9 and the Memorial Sloan Kettering
Venkata Pokuri, Norbert Sule, Yousef Soofi, Bo Xu, Khurshid Guru, and Saby George
transurethral resection (TUR) of the bladder tumor. After resection, the tumor base was cauterized and a mitomycin cocktail was left indwelling. Hematuria subsided with TUR. Based on pathology report, patient was started on neoadjuvant chemotherapy with a GC
Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Britt-Marie Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Mary Lou Smith, George Somlo, Neal S. Topham, John H. Ward, Eric P. Winer, and Antonio C. Wolff
guidelines, at www.NCCN.org [ST-1]). 5 , 6 This revision differs from the 1997 edition of the AJCC staging by incorporating the increasing use of novel imaging and pathology techniques used at diagnosis (e.g., sentinel node biopsy and immunohistochemistry
Jonathan M. Loree and Scott Kopetz
Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology [published online ahead of print February 6, 2017] . J Clin Oncol , doi: 10.1200/JCO.2016.71.9807 . 2
Robert A. Swarm and Maria Dans
C, and HIV. In LMCs, late-stage presentation and inaccessible diagnosis and treatment are common. Only 26% of LMCs have available pathology service, and fewer than one-third have treatment services available in the public sector. Other barriers to
Katherine Cotangco, Mary Meram, and M. Patrick Lowe
subsequently underwent a dilation and curettage. Pathology results suggested leiomyosarcoma. A CT scan of the chest, abdomen, and pelvis revealed a right uterine body peripherally enhancing partially calcified necrotic 5.8 × 5.0-cm mass, bilateral pulmonary
Alexander S. Baras, Jarushka Naidoo, Christine L. Hann, Peter B. Illei, Charles W. Reninger III, and Josh Lauring
(45 U/L). Fiberoptic bronchoscopy was performed with fine-needle aspiration (FNA) of a station 7 lymph node, and the pathology was read as poorly differentiated squamous cell carcinoma (SCC) ( Figure 2 ). Immunostains were positive for p63 and negative
Jaffer A. Ajani
2013 ; 8 : 1558 – 1562 . 9. Taketa T Sudo K Correa AM . Post chemoradiation surgical pathology stage can customize the surveillance strategy in patients with esophageal adenocarcinoma . J Natl Compr Canc Netw , in press . 10
