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-term use of hormonal agents such as tamoxifen and aromatase inhibitors can cause vasomotor and musculoskeletal symptoms. 3 For both men and women who have had surgery for rectal cancer, sexual problems afterward are “common, multifactorial, inadequately

trastuzumab: a clinically active regimen [abstract] . J Clin Oncol 2005 ; 23 ( suppl 1 ): Abstract 559 . 68. Chu I Blackwell K Chen S . The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell

cancer. 10 If the rate of unrelated cancers in the opposite breast is the same as those in the same breast, then approximately half of the ipsilateral recurrences could be biologically new cancers. The greater effectiveness of radiation, tamoxifen, and

capecitabine, gemcitabine, or docetaxel. Tamoxifen, a selective ER modulator, has been used successfully to treat ER-positive metastatic SC in a 70-year-old man, who had no progression at 41-month follow-up. 7 We therefore, based on the aforementioned report

the risk of death compared with standard chemotherapy, 27 and overtreatment with lumpectomy plus tamoxifen and radiation therapy has shown no benefit compared with lumpectomy plus adjuvant therapy with tamoxifen alone. 28 In our study of patients

amplification and response to either tamoxifen or aromatase inhibitors. 85 , 88 – 91 Despite inconsistent data, however, HER2 status has been, and may continue to be, considered in clinical decision-making involving hormonal therapies. 92 Trastuzumab with

are known inhibitors of hepatic drug metabolism via inhibition of cytochrome P450 enzymes, especially CYP2D6. Tamoxifen is an estrogen receptor blocker commonly used in patients with hormone receptor-positive breast cancer. Tamoxifen undergoes

lumpectomy alone, both with tamoxifen for 5 years. Locoregional recurrence rates were 1% in the lumpectomy, radiation, and tamoxifen arm and 4% in the lumpectomy plus tamoxifen arm. No differences were seen in overall survival, disease-free survival, or need

women. 66 , 70 , 71 Among postmenopausal women, it is well established that aromatase inhibitors are more effective than tamoxifen. 66 , 72 , 73 Several studies have explored combination approaches with endocrine therapy and targeted therapy. For

relationship between sleep and age in patients and survivors diagnosed with breast cancer. Cancer Treatments Lorizio et al 33 reported that women with higher levels of endoxifen, the most active metabolite of tamoxifen, were more likely to experience