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NCCN Guidelines Insights: Kidney Cancer, Version 1.2021

Featured Updates to the NCCN Guidelines

Robert J. Motzer, Eric Jonasch, Shawna Boyle, Maria I. Carlo, Brandon Manley, Neeraj Agarwal, Ajjai Alva, Katy Beckermann, Toni K. Choueiri, Brian A. Costello, Ithaar H. Derweesh, Arpita Desai, Saby George, John L. Gore, Naomi Haas, Steven L. Hancock, Christos Kyriakopoulos, Elaine T. Lam, Clayton Lau, Bryan Lewis, David C. Madoff, Brittany McCreery, M. Dror Michaelson, Amir Mortazavi, Lakshminarayanan Nandagopal, Phillip M. Pierorazio, Elizabeth R. Plimack, Lee Ponsky, Sundhar Ramalingam, Brian Shuch, Zachary L. Smith, Bradley Somer, Jeffrey Sosman, Mary A. Dwyer, and Angela D. Motter

information about 7 of the most common hereditary RCC syndromes, as well as genetic risk assessment, testing, surveillance, and treatment recommendations for patients who are suspected or confirmed to have one of these syndromes (see HRCC-1 , HRCC-2 , GENE

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Heather H. Cheng, Alexandra O. Sokolova, Edward M. Schaeffer, Eric J. Small, and Celestia S. Higano

), referral to a genetic counselor for dedicated, confirmatory germline testing is indicated. Family and Personal History of Cancer Family history of cancer remains a foundation of genetic risk assessment, and inquiring about prostate and nonprostate cancers

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initiative is titled “Impact of implementing the NCCN Guidelines for genetic/familial high-risk assessment: breast and ovarian in clinical practice.” The awardees responded to a request for proposals issued by the NCCN Foundation to the 21 NCCN Member

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Caiqian Cropper, Ashley Woodson, Banu Arun, Carlos Barcenas, Jennifer Litton, Sarah Noblin, Diane Liu, Minjeong Park, and Molly Daniels

Guidelines) for Genetic/Familial High-Risk Assessment: Breast and Ovarian 17 includes clinical criteria for when to recommend BRCA1/2 genetic testing. These criteria do not use a pretest mutation probability threshold; rather, they list personal

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Brandie Heald, Shanna Gustafson, Jessica Mester, Patricia Arscott, Katherine Lynch, Jessica Moline, and Charis Eng

). The most common reason for referral was a personal and/or family history of breast cancer (n=190). Figure 1 summarizes the suspected diagnoses, based on risk assessment of reported personal and family history information, for the patients seen at

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Christos Vaklavas, John R. Ross, Lisle M. Nabell, Andres Forero, Martin J. Heslin, and Tina E. Wood

estimates may rely on prediction models, such as those developed for breast cancer, 4 and risk stratification, such as that used in colorectal cancer risk assessment. 5 Absent a single-gene high-penetrance syndrome (as is the case for most patients), the

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Rita A. Mukhtar, Jasmine M. Wong, and Laura J. Esserman

presence of these lesions. 38 Potential changes in terminology could eliminate the word carcinoma , use the IDLE nomenclature, or add more information to the current traditional descriptors, such as a risk assessment. The Athena Breast Health Network, a

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Philip J. Saylor and Matthew R. Smith

to benefit from drug therapy to prevent fractures. Historically, risk assessment centered on dual-energy radiograph absorptiometry scan measurement of BMD. Reliance on this measurement alone, however, is inadequate because most fractures occur in men

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Therese B. Bevers, John H. Ward, Banu K. Arun, Graham A. Colditz, Kenneth H. Cowan, Mary B. Daly, Judy E. Garber, Mary L. Gemignani, William J. Gradishar, Judith A. Jordan, Larissa A. Korde, Nicole Kounalakis, Helen Krontiras, Shicha Kumar, Allison Kurian, Christine Laronga, Rachel M. Layman, Loretta S. Loftus, Martin C. Mahoney, Sofia D. Merajver, Ingrid M. Meszoely, Joanne Mortimer, Lisa Newman, Elizabeth Pritchard, Sandhya Pruthi, Victoria Seewaldt, Michelle C. Specht, Kala Visvanathan, Anne Wallace, Mary Ann Bergman, and Rashmi Kumar

express written permission of NCCN®. Elements of Risk and Risk Assessment Estimation of breast cancer risk for a woman with no personal history of invasive breast cancer or ductal carcinoma in situ (DCIS) begins with an initial assessment of

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Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Don Dizon, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, Muhammad Raza, M. Alma Rodriguez, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass

, fatigue, distress, or nutritional deficits can facilitate the initiation of an exercise program. Risk Assessment for Exercise-Induced Adverse Events: Exercise is considered safe for most survivors. 16 , 17 , 36 However, a significant portion of