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Amy Ly, Jill C. Ono, Kevin S. Hughes, Martha B. Pitman, and Ronald Balassanian

, radial scar in an excision specimen, and papilloma. Indeterminate lesions encompassed radial scar in a core biopsy, atypical papillary lesion, flat epithelial atypia (FEA), atypical ductal hyperplasia, atypical lobular hyperplasia/lobular carcinoma in

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Kari E. Hacker, Shitanshu Uppal, and Carolyn Johnston

common, more frequently bilateral (30%–40%), confined to the ovaries, and likely to exhibit benign behavior even at higher stages. 39 , 40 Updated genetic assessments suggest that seromucinous BOTs do not have a serous component despite some papillary

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Samir Gupta, Dawn Provenzale, Xavier Llor, Amy L. Halverson, William Grady, Daniel C. Chung, Sigurdis Haraldsdottir, Arnold J. Markowitz, Thomas P. Slavin Jr, Heather Hampel, CGC, Reid M. Ness, Jennifer M. Weiss, Dennis J. Ahnen, Lee-may Chen, Gregory Cooper, Dayna S. Early, Francis M. Giardiello, Michael J. Hall, Stanley R. Hamilton, Priyanka Kanth, Jason B. Klapman, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, June Mikkelson, CGC, Shajan Peter, Scott E. Regenbogen, Mary A. Dwyer, CGC, and Ndiya Ogba

. Increased risk warranting genetic evaluation may be indicated by, but not restricted to, personal or family history of congenital hypertrophy of the retinal pigment epithelium, osteomas, supernumerary teeth, desmoid tumor, cribriform variant of papillary

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Rajmohan Murali, Deborah F. Delair, Sarah M. Bean, Nadeem R. Abu-Rustum, and Robert A. Soslow

immunohistochemical similarities to the cervical tumors. These uterine tumors are termed mesonephric-like carcinomas , 66 , 67 and display a uniform appearance, with tubular, solid and papillary architectural patterns, and are composed of cells with atypical

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Matthew F. Kalady

appearance is the recognition of type II open pits, which are thought to represent dilated crypt bases that are wider and rounder than the papillary or stellate (type II) pits found in the HPs and TSAs. This finding was associated with BRAF mutations and

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David S. Ettinger, Mark Agulnik, Justin M. M. Cates, Mihaela Cristea, Crystal S. Denlinger, Keith D. Eaton, Panagiotis M. Fidias, David Gierada, Jon P. Gockerman, Charles R. Handorf, Renuka Iyer, Renato Lenzi, John Phay, Asif Rashid, Leonard Saltz, Lawrence N. Shulman, Jeffrey B. Smerage, Gauri R. Varadhachary, Jonathan S. Zager, and Weining (Ken) Zhen

signs. 3 , 21 - 23 Favorable prognostic factors include poorly differentiated carcinoma with midline distribution, women with papillary adenocarcinoma of the peritoneal cavity, women with adenocarcinoma involving only axillary lymph nodes, SCC involving

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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher, and Jeffrey N. Weitzel

approximately 70% of individuals with Cowden syndrome, 96 and the lifetime risk for thyroid cancer (follicular or papillary) has been estimated at 3% to 10%. 11 , 97 As in many other hereditary cancer syndromes, affected individuals are more likely to develop

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Kamran Aghayev, Frank Vrionis, and Marc C. Chamberlain

invasive tumors with nerve root encasement and even extravertebral invasion have been reported. Histologically, myxopapillary ependymomas are characterized by myxoid changes in the stroma and papillary organization of tumor cells. 85 Microsurgery plays an

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Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad K. Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, and Susan Darlow

-morular variant of papillary thyroid cancer, hepatoblastoma, or multiple gastrointestinal hamartomatous polyps). Detailed strategies for screening for Lynch syndrome are provided below; see the NCCN guidelines for detail on follow-up patients meeting risk criteria

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, endometrial, papillary urothelial, gastric, melanoma, and urinary tract cancers. More research is needed to understand the relationship between PALB2 and other cancer risks, particularly in males because they represented <1% of patients tested in this study