mutations and the risk of papillary thyroid cancer . Int J Cancer 2015 ; 137 : 548 – 552 . 52. Friedrichsen DM Malone KE Doody DR . Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
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Rishi Jain, Michelle J. Savage, Andrea D. Forman, Reetu Mukherji, and Michael J. Hall
Al B. Benson III, Thomas A. Abrams, Edgar Ben-Josef, P. Mark Bloomston, Jean F. Botha, Bryan M. Clary, Anne Covey, Steven A. Curley, Michael I. D'Angelica, Rene Davila, William D. Ensminger, John F. Gibbs, Daniel Laheru, Mokenge P. Malafa, Jorge Marrero, Steven G. Meranze, Sean J. Mulvihill, James O. Park, James A. Posey, Jasgit Sachdev, Riad Salem, Elin R. Sigurdson, Constantinos Sofocleous, Jean-Nicolas Vauthey, Alan P. Venook, Laura Williams Goff, Yun Yen, and Andrew X. Zhu
. 174 Yeh CN Jan YY Yeh TS . Hepatic resection of the intraductal papillary type of peripheral cholangiocarcinoma . Ann Surg Oncol 2004 ; 11 : 606 – 611 . 175 Nakagohri T Asano T Kinoshita H . Aggressive surgical resection for hilar
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019
Featured Updates to the NCCN Guidelines
Samir Gupta, Dawn Provenzale, Xavier Llor, Amy L. Halverson, William Grady, Daniel C. Chung, Sigurdis Haraldsdottir, Arnold J. Markowitz, Thomas P. Slavin Jr, Heather Hampel, CGC, Reid M. Ness, Jennifer M. Weiss, Dennis J. Ahnen, Lee-may Chen, Gregory Cooper, Dayna S. Early, Francis M. Giardiello, Michael J. Hall, Stanley R. Hamilton, Priyanka Kanth, Jason B. Klapman, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, June Mikkelson, CGC, Shajan Peter, Scott E. Regenbogen, Mary A. Dwyer, CGC, and Ndiya Ogba
. Increased risk warranting genetic evaluation may be indicated by, but not restricted to, personal or family history of congenital hypertrophy of the retinal pigment epithelium, osteomas, supernumerary teeth, desmoid tumor, cribriform variant of papillary
Amy Ly, Jill C. Ono, Kevin S. Hughes, Martha B. Pitman, and Ronald Balassanian
, radial scar in an excision specimen, and papilloma. Indeterminate lesions encompassed radial scar in a core biopsy, atypical papillary lesion, flat epithelial atypia (FEA), atypical ductal hyperplasia, atypical lobular hyperplasia/lobular carcinoma in
Karolina Kata, Juan C. Rodriguez-Quintero, Octavio D. Arevalo, Jackie J. Zhang, Meenakshi Bidwai Bhattacharjee, Cornelius Ware, Antonio Dono, Roy Riascos-Castaneda, Nitin Tandon, Angel Blanco, Yoshua Esquenazi, Leomar Y. Ballester, Mark Amsbaugh, Arthur L. Day, and Jay-Jiguang Zhu
advanced melanoma. 9 It has also shown encouraging results in BRAF V600E–mutated non–small cell lung cancer, papillary thyroid cancer, and central nervous system (CNS) neoplasms, including PXA. 10 – 12 Despite the encouraging response, resistance to
NCCN Guidelines® Insights: Ovarian Cancer, Version 3.2022
Featured Updates to the NCCN Guidelines
Deborah K. Armstrong, Ronald D. Alvarez, Floor J. Backes, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Lee-may Chen, Viola C. Chitiyo, Mihaela Cristea, Maria DeRosa, Eric L. Eisenhauer, David M. Gershenson, Heidi J. Gray, Rachel Grisham, Ardeshir Hakam, Angela Jain, Amer Karam, Gottfried E. Konecny, Charles A. Leath III, Gary Leiserowitz, Joyce Liu, Lainie Martin, Daniela Matei, Michael McHale, Karen McLean, David S. Miller, Sanja Percac-Lima, Steven W. Remmenga, John Schorge, Daphne Stewart, Premal H. Thaker, Roberto Vargas, Andrea Wahner Hendrickson, Theresa L. Werner, Emese Zsiros, Mary A. Dwyer, and Lisa Hang
included in the primary analysis, 5 had LGSC and 1 had mucinous-papillary serous adenocarcinoma of peritoneum. The ORR of the overall population was 38%, with a PFS of 11.4 months. Notably, a clinical benefit was observed in all 6 patients with primary
Kari E. Hacker, Shitanshu Uppal, and Carolyn Johnston
common, more frequently bilateral (30%–40%), confined to the ovaries, and likely to exhibit benign behavior even at higher stages. 39 , 40 Updated genetic assessments suggest that seromucinous BOTs do not have a serous component despite some papillary
Rajmohan Murali, Deborah F. Delair, Sarah M. Bean, Nadeem R. Abu-Rustum, and Robert A. Soslow
immunohistochemical similarities to the cervical tumors. These uterine tumors are termed mesonephric-like carcinomas , 66 , 67 and display a uniform appearance, with tubular, solid and papillary architectural patterns, and are composed of cells with atypical
Matthew F. Kalady
appearance is the recognition of type II open pits, which are thought to represent dilated crypt bases that are wider and rounder than the papillary or stellate (type II) pits found in the HPs and TSAs. This finding was associated with BRAF mutations and
David S. Ettinger, Mark Agulnik, Justin M. M. Cates, Mihaela Cristea, Crystal S. Denlinger, Keith D. Eaton, Panagiotis M. Fidias, David Gierada, Jon P. Gockerman, Charles R. Handorf, Renuka Iyer, Renato Lenzi, John Phay, Asif Rashid, Leonard Saltz, Lawrence N. Shulman, Jeffrey B. Smerage, Gauri R. Varadhachary, Jonathan S. Zager, and Weining (Ken) Zhen
signs. 3 , 21 - 23 Favorable prognostic factors include poorly differentiated carcinoma with midline distribution, women with papillary adenocarcinoma of the peritoneal cavity, women with adenocarcinoma involving only axillary lymph nodes, SCC involving
