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Matthew E. Nielsen, Bruce J. Trock, and Patrick C. Walsh

secondary local therapy may interrupt the natural history of disease and prevent progression to systemic disease. A basic question in this context is the extent to which this sequence of events—versus the presence of occult metastases at surgery

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Siddhartha Yadav, Sri Harsha Tella, Anuhya Kommalapati, Kristin Mara, Kritika Prasai, Mohamed Hamdy Mady, Mohamed Hassan, Rory L. Smoot, Sean P. Cleary, Mark J. Truty, Lewis R. Roberts, and Amit Mahipal

( Table 2 ). On MVA, age, ECOG performance status, presence of distant metastases, ALP level >200 U/L, and HgB level <9 g/dL were shown to determine median OS ( Table 3 ). Tumor size ≥5 cm was associated with an elevated hazard ratio (HR) of 1.24 compared

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George D. Demetri, Robert S. Benjamin, Charles D. Blanke, Jean-Yves Blay, Paolo Casali, Haesun Choi, Christopher L. Corless, Maria Debiec-Rychter, Ronald P. DeMatteo, David S. Ettinger, George A. Fisher, Christopher D. M. Fletcher, Alessandro Gronchi, Peter Hohenberger, Miranda Hughes, Heikki Joensuu, Ian Judson, Axel Le Cesne, Robert G. Maki, Michael Morse, Alberto S. Pappo, Peter W. T. Pisters, Chandrajit P. Raut, Peter Reichardt, Douglas S. Tyler, Annick D. Van den Abbeele, Margaret von Mehren, Jeffrey D. Wayne, and John Zalcberg

%) are less common primary sites. 14 A few GISTs occur within the abdomen and retroperitoneum but show no clear anatomic association with the GI tract. 15 Liver metastases and/or dissemination within the abdominal cavity are the usual clinical

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George D. Demetri, Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W.T. Pisters, Chandrajit P. Raut, Richard F. Riedel, Scott Schuetze, Hema M. Sundar, Jonathan C. Trent, and Jeffrey D. Wayne

stromal tumors. 15 Recurrence after resection is predominantly intra-abdominal, and the liver is the most common site of recurrence in patients with primary presentation and those with metastatic disease at presentation. 16 Lymph node metastases are

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Ami M. Vyas, Hilary Aroke, and Stephen J. Kogut

metastases) at 3.2%. Conclusion: Almost one quarter of the study cohort did not receive guideline-concordant care. There are opportunities to improve cancer care for women with negative HR status who have lower socioeconomic status. The high unexplained

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Maral DerSarkissian, Shuanglian Li, Aaron Galaznik, Rachel Bhak, Iryna Bocharova, Thomas Kulalert, Huamao M. Lin, Hui Huang, and Mei Sheng Duh

.5%). Among 83 TN and 47 RR patients with known ECOG score at advanced diagnosis, most had score 0–1 (TN: 56.3%; RR: 62.0%). Central nervous system metastases were observed in 35.2% of TN and 33.8% of RR patients. While 45.3% of TN patients received any

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Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force

. This training set outperformed all clinical variables in predicting the likelihood of distant metastases within 5 years in this group of women younger than 55 years of age and with lymph node–negative breast cancer. A subsequent validation study was

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Giuseppe Curigliano

Boston, MA, U.S.A.; Tuesday, 9.40 a.m. Patient: “Doctor, I am very worried about the CT scan report. It says ‘disease progression.’ ‘Progression’ means I have metastases, doesn’t it? How long will I live?” Milan, Italy; Tuesday, 11.00 a

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Jennifer Shih, Babar Bashir, Karen S. Gustafson, Mark Andrake, Roland L. Dunbrack, Lori J. Goldstein, and Yanis Boumber

2 ). Based on the morphology and immunohistochemical profile, a lung primary was favored. A staging PET/CT confirmed the CT findings of at least stage IIIb disease. A brain MRI unfortunately showed 2 small cerebral metastases in the right and left

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Owen Tan, Deborah J. Schofield, and Rupendra Shrestha

from a combination of pathology reports, inpatient notifications, and other treatment facilities. The variable was categorized as localized to tissue of origin, regional spread, adjacent organs and/or regional lymph nodes, distant metastases, and