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Translating Genomics in Cancer Care

Yvonne Bombard, Peter B. Bach, and Kenneth Offit

Genomics in Cancer Care There is increasing enthusiasm for genomics and its promise in advancing personalized medicine. 1 - 3 However, the application of genomics in health care is not a novel concept. Genetic testing and risk assessment

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NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019

Featured Updates to the NCCN Guidelines

Samir Gupta, Dawn Provenzale, Xavier Llor, Amy L. Halverson, William Grady, Daniel C. Chung, Sigurdis Haraldsdottir, Arnold J. Markowitz, Thomas P. Slavin Jr, Heather Hampel, CGC, Reid M. Ness, Jennifer M. Weiss, Dennis J. Ahnen, Lee-may Chen, Gregory Cooper, Dayna S. Early, Francis M. Giardiello, Michael J. Hall, Stanley R. Hamilton, Priyanka Kanth, Jason B. Klapman, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, June Mikkelson, CGC, Shajan Peter, Scott E. Regenbogen, Mary A. Dwyer, CGC, and Ndiya Ogba

for genetic testing (see the complete version of these guidelines at NCCN.org ). Criteria for Evaluation of Polyposis Syndromes Previously identified polyposis syndromes include FAP, attenuated FAP (AFAP), MAP, and other rare genetic causes of

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Point: Justification for Lynch Syndrome Screening Among All Patients With Newly Diagnosed Colorectal Cancer

Heather Hampel

counseling and elected to pursue genetic testing (∼6 relatives per proband). 1 Of these, 109 were diagnosed with Lynch syndrome and 140 learned that they did not inherit Lynch syndrome. This study resulted in major cancer surveillance differences for 293

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Pharmacogenetics in the Treatment and Supportive Care of Patients With Cancer

Presented by: David S. Craig

Oncology [NCCN Guidelines] for Adult Cancer Pain,” Dr. Craig remarked ( Figure 1 ). “We tried to take a very comprehensive but simplified approach on what to do for genetic testing, who should be tested, and what we [should be] looking for.” Figure 1

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Updates in the Systemic Therapy Options for Clear Cell and Non–Clear Cell Renal Cell Carcinoma

Presented by: Philippe E. Spiess, Peter A.S. Johnstone, and Eric Jonasch

workup, (2) consideration of pretreatment biopsy, and (3) role of genetic testing, he said. This patient underwent a comprehensive blood panel, and results of the chest CT scan were normal; a renal scan showed differential renal function of

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Inherited Mutations in Chinese Men With Prostate Cancer

Yao Zhu, Yu Wei, Hao Zeng, Yonghong Li, Chi-Fai Ng, Fangjian Zhou, Caiyun He, Guangxi Sun, Yuchao Ni, Peter K.F. Chiu, Jeremy Y.C. Teoh, Beihe Wang, Jian Pan, Fangning Wan, Bo Dai, Xiaojian Qin, Guowen Lin, Hualei Gan, Junlong Wu, and Dingwei Ye

), but detailed clinical characteristics were not available for patients from the commercial laboratory. Patients from the laboratory were offered germline sequencing, according to the genetic testing recommendations in the NCCN Clinical Practice

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Multigene Testing for Hereditary Cancer: When, Why, and How

Kenneth Offit

with Lynch mutations. This patient inherited an MSH2 mutation, leading to a risk for colon cancer in his relatives,” he explained. The time may be approaching for agnostic genetic testing, Dr. Offit predicted, “but this will require new approaches to

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Increasing Private Payer and Medicare Coverage of Circulating Tumor DNA Tests: What’s at Stake?

Mariana P. Socal

billion a year—and the increasing contribution of genetic testing to laboratory test expenses. Genetic testing is estimated to have grown to 20% of expenses, up from about 5% a decade ago. 7 , 8 The role of LBMs in the Medicare market is unknown, but MACs

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NCCN News

– 30 . 26742998 10.3322/caac.21332 Outcomes4Me and NCCN Expand Global Collaboration to Include Genetic Testing for Hereditary Cancer Outcomes4Me Inc., developer of a leading free mobile app and platform to empower patients with cancer with the

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NCCN News

Programming and Enhance Genetic Testing Discussions Two new measurements have been added to the Health Equity Report Card ( HERC )—a tool for improving the quality and equity of cancer care. The new measures were put forth by a multidisciplinary working