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Extending Comprehensive Cancer Center Expertise in Clinical Cancer Genetics and Genomics to Diverse Communities: The Power of Partnership

Deborah J. MacDonald, Kathleen R. Blazer, and Jeffrey N. Weitzel

R apidly evolving genetic and genomic technologies for genetic cancer risk assessment (GCRA) are revolutionizing the approach to targeted therapy and cancer screening and prevention, heralding the era of personalized medicine. Although academic

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Our Experience With Photodynamic Diagnosis and Photodynamic Therapy for Lung Cancer

Harubumi Kato

Along with preventive strategies for eradicating lung cancer, detection and localization of small early-stage lung tumors are crucial for obtaining better therapeutic results, stated Harubumi Kato, MD, PhD, Professor, Department of Surgery, Tokyo

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Current Surveillance After Treatment is Not Sufficient for Patients With Rectal Cancer With Negative Baseline CEA

Dingcheng Shen, Xiaolin Wang, Heng Wang, Gaopo Xu, Yumo Xie, Zhuokai Zhuang, Ziying Huang, Juan Li, Jinxin Lin, Puning Wang, Meijin Huang, Yanxin Luo, and Huichuan Yu

Background Colorectal cancer (CRC) is one of the most common cancers and is a leading cause of cancer-related mortality worldwide. 1 , 2 Approximately 25% to 40% of patients will develop recurrent disease after a curative resection with

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Head and Neck Cancers

Duke Comprehensive Cancer Center

Oral cavity, pharyngeal, and laryngeal cancers account for about 3% of new cancer cases in the United States. Alcohol and tobacco abuse are common etiologic factors in some of these cancers. Moreover, because the entire aerodigestive tract epithelium may be exposed to these carcinogens, patients with head and neck cancer are at risk for developing second primary neoplasms. Stage at diagnosis is the most predictive factor of survival. Important new updates to the NCCN guidelines for 2008 include the addition of chemo/radiation therapy as an option in adjuvant treatment for several head and neck cancers and the addition of human papilloma virus testing to the workup. This version of the guidelines is limited to tumors arising in the oral cavity, oropharynx, hypopharynx, nasopharynx, and glottic and supraglottic larynx. The complete version can be found on the NCCN Web site at

For the most recent version of the guidelines, please visit

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NCCN Task Force Report: Bone Health in Cancer Care

Julie R. Gralow, J. Sybil Biermann, Azeez Farooki, Monica N. Fornier, Robert F. Gagel, Rashmi Kumar, Georgia Litsas, Rana McKay, Donald A. Podoloff, Sandy Srinivas, and Catherine H. Van Poznak

Assessing Bone Health Osteoporosis and its associated increase in fracture risk is a major health issue for the aging population, and especially for patients with cancer. Hip and vertebral fractures are associated with chronic pain, decreased

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Cancer Patient Survival and Erythropoietin

John A. Glaspy

anemic cancer patients when referenced to the general population . J Clin Oncol 2003 ; 21 : 366 – 373 . 2 Cella D Kallich J McDermott A Xu X . The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer

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Impact of Prostate Cancer Diagnosis on Noncancer Hospitalizations Among Elderly Medicare Beneficiaries With Incident Prostate Cancer

Amit D. Raval, Suresh Madhavan, Malcolm D. Mattes, Mohamad Salkini, and Usha Sambamoorthi

Background The period immediately after cancer diagnosis can be considered a point of turbulence for the management of preexisting chronic conditions. Cancer is often considered a dominant condition that eclipses the management of all other

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Comparing the Association Between Insurance and Mortality in Ovarian, Pancreatic, Lung, Colorectal, Prostate, and Breast Cancers

Alexander P. Cole, Chang Lu, Marieke J. Krimphove, Julie Szymaniak, Maxine Sun, Sean A. Fletcher, Stuart R. Lipsitz, Brandon A. Mahal, Paul L. Nguyen, Toni K. Choueiri, Adam S. Kibel, Adil H. Haider, and Quoc-Dien Trinh

Background Insurance coverage impacts many aspects of cancer care, from screening 1 , 2 to treatment. 3 – 5 Insurance may also affect long-term outcomes, such as cancer progression and mortality. 6 , 7 The relative benefit may vary depending on

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Update on Guidelines for the Prevention of Cancer-Associated Thrombosis

Amro Elshoury, Jordan K. Schaefer, Ming Y. Lim, Deidre P. Skalla, and Michael B. Streiff

In 1823, Jean-Baptiste Bouillaud published the first report of an association between thrombosis and cancer. 1 In 1865, Trousseau identified the association between gastric cancer and venous thrombosis, 2 and the combination of the 2

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Determinants of Enrollment in Cancer Clinical Trials: The Relationship Between the Current State of Knowledge, Societal Disease Burden, and Randomized Clinical Trial Enrollment

Shane Lloyd, Daniela L. Buscariollo, Cary P. Gross, Danil V. Makarov, and James B. Yu

Given the finite resources for cancer research, understanding the focus of current clinical research efforts and the factors influencing these efforts is important. 1 Ideally, research efforts should be focused on maximizing the potential for