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Philip J. Saylor and Matthew R. Smith

in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer . J Clin Oncol 2008 ; 26 : 4875 – 4882 . 75. Lewiecki EM Miller PD McClung MR . Two-year treatment with denosumab (AMG 162

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Kari E. Hacker, Shitanshu Uppal, and Carolyn Johnston

, similar to those seen with aromatase inhibitor therapy, with the use of the oral MEK1/2 inhibitor selumetinib, such that 15% and 65% of patients had an objective clinical response and stable disease, respectively. 82 Several questions remain, including

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Steven J. Isakoff, Janice Lyons, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena S. Moran, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda L. Telli, John H. Ward, Rashmi Kumar, and Dorothy A. Shead

women) or an aromatase inhibitor (for postmenopausal women, especially those under 60 years of age or those with concerns of embolism), may be considered as a strategy to reduce the risk of ipsilateral breast cancer recurrence in women with ER

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Yuan-Yuan Lei, Suzanne C. Ho, Ashley Cheng, Carol Kwok, Chi-Kiu Iris Lee, Ka Li Cheung, Roselle Lee, Herbert H.F. Loong, Yi-Qian He, and Winnie Yeo

-conserving surgery, chemotherapy, radiation therapy, hormone therapy such as tamoxifen and aromatase inhibitors, and anti-HER2 therapy). At baseline and 18-month follow-up, the self-reported total comorbidity counts included diabetes, hypertension, hyperlipidemia

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

status. One percent of breast cancers occur in men, 1 and men with breast cancer should be treated similarly to postmenopausal women, except that the use of aromatase inhibitors is ineffective without concomitant suppression of testicular steroidogenesis

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William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Bethany Anderson, Harold J. Burstein, Helen Chew, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Joanne Mortimer, Sameer A. Patel, Lori J. Pierce, Laura H. Rosenberger, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer Burns, and Rashmi Kumar

Management of DCIS After Primary Treatment According to the NCCN Panel, in patients with ER-positive DCIS treated with BCT, endocrine therapy with tamoxifen (for premenopausal and postmenopausal patients) or an aromatase inhibitor (for postmenopausal

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fulvestrant was 11.7%, 8.8%, 7.6%, and 6.5%). Conclusions: Among postmenopausal women with HR + /HER2 − mBC, approximately two-thirds of patients received first-line ET. Although nonsteroidal aromatase inhibitors (NSAIs; anastrozole or letrozole) may be

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Laura M. Spring, Yael Bar, and Steven J. Isakoff

women. 66 , 70 , 71 Among postmenopausal women, it is well established that aromatase inhibitors are more effective than tamoxifen. 66 , 72 , 73 Several studies have explored combination approaches with endocrine therapy and targeted therapy. For

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Therese B. Bevers, John H. Ward, Banu K. Arun, Graham A. Colditz, Kenneth H. Cowan, Mary B. Daly, Judy E. Garber, Mary L. Gemignani, William J. Gradishar, Judith A. Jordan, Larissa A. Korde, Nicole Kounalakis, Helen Krontiras, Shicha Kumar, Allison Kurian, Christine Laronga, Rachel M. Layman, Loretta S. Loftus, Martin C. Mahoney, Sofia D. Merajver, Ingrid M. Meszoely, Joanne Mortimer, Lisa Newman, Elizabeth Pritchard, Sandhya Pruthi, Victoria Seewaldt, Michelle C. Specht, Kala Visvanathan, Anne Wallace, Mary Ann Bergman, and Rashmi Kumar

function. 137 Aromatase Inhibitors for Risk Reduction: Several clinical trials testing the use of aromatase inhibitors (AIs) in the adjuvant therapy of postmenopausal women with invasive breast cancer have been reported. The first of these studies, the

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, with the primary QoL outcomes being the ones representing general health (GH). Results: A total of 10 studies (representing 5 RCTs) were identified in the SLR. The study populations included first-line (n=4) and aromatase inhibitor (AI