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recent prospective trial to date evaluating zoledronic acid in addition to standard adjuvant therapy in ESBC. 21 At the final efficacy analysis after a median follow-up Table 1 Characteristics of Published Phase III Trials With Zoledronic Acid

improve 10-year OS compared with observation (51.8% vs 48.4%; P =.32). 13 Although early analysis demonstrated a DFS benefit of adjuvant therapy for patients with ypT0–2 (hazard ratio [HR], 0.64; 95% CI, 0.45–0.91; P =.13), this benefit was not observed

the question as to the utility of the current standard of care, which is 6 months of perioperative systemic therapy. Given the unclear utility of adjuvant therapy after preoperative therapy has been administered, the clinical importance of pathologic

dissection for melanoma . J Clin Oncol 2004 ; 22 : 3677 – 3684 . 70 Cascinelli N Belli F MacKie RM . Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised

as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2–positive breast cancer . J Clin Oncol 2012 ; 30 : 3792 – 3799 . 5. Bonneterre J Roché H Kerbrat P . Long-term cardiac follow-up in relapse

fusion gene EML-4 ALK . This mutation seems to be mutually exclusive with the EGFR and KRAS mutation in the phase I study. Adjuvant Therapy In 2004, the International Adjuvant Lung Cancer Trial showed an approximately 5% survival advantage

1998 ; 17 : 101 . 65 Eifel P Axelson JA Costa J . National Institutes of Health Consensus Development Conference Statement: Adjuvant therapy for breast cancer, November 1-3 2000 . J Natl Cancer Inst 2001 ; 93 : 979 . www

should be tempered by maximal preservation of neurologic function. What does seem to be apparent is that STR without any adjuvant therapy is associated with a poor prognosis. There have been 16 cases presented in the literature that have undergone STR or

LA , Davis GJ , . Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer . J Clin Oncol 2001 ; 19 : 980 – 991 . 11181660 10.1200/JCO.2001.19.4.980 2. Wishart GC , Azzato EM , Greenberg

predictor of survival and determines the indication for additional surgery (ie, complete lymph node dissection), systemic adjuvant therapy, surveillance imaging, and frequency of clinical follow-up. However, controversy remains regarding the most appropriate