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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

postmenopausal women, except that tamoxifen is the preferred adjuvant treatment. 5 – 9 There are limited clinical data on the efficacy of single-agent aromatase inhibitors in men, and aromatase inhibitors may be combined with gonadotropic hormone

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Rita A. Mukhtar, Jasmine M. Wong, and Laura J. Esserman

lumpectomy and tamoxifen with or without radiation. The radiation group was significantly less likely to experience local relapse at 5 years (0.6% vs 7.7%; P <.001) and axillary relapse (0.5% vs 2.5%; P =.049). However, no difference was seen in distant

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Cindy Railton, Sasha Lupichuk, Jennifer McCormick, Lihong Zhong, Jenny Jaeeun Ko, Barbara Walley, Anil A. Joy, and Janine Giese-Davis

. From pharmacy records, we measured nonadherence (filled prescriptions covered ≤80% of potential time on therapy), nonpersistence (continuous period >6 months when no prescription was filled), and frequency and timing of planned switches from tamoxifen

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Eve Henry, Victor Villalobos, Lynn Million, Kristin C. Jensen, Robert West, Kristen Ganjoo, Alexandra Lebensohn, James M. Ford, and Melinda L. Telli

an opposed tangent technique, which delivered 50.4 Gy in 28 fractions to the whole breast, followed by a 10-Gy boost to the lumpectomy cavity. She was then lost to follow-up and did not receive the intended course of adjuvant tamoxifen nor the

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Michelle E. Melisko and Joseph B. Narus

-term use of hormonal agents such as tamoxifen and aromatase inhibitors can cause vasomotor and musculoskeletal symptoms. 3 For both men and women who have had surgery for rectal cancer, sexual problems afterward are “common, multifactorial, inadequately

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Fiona Tsui-Fen Cheng, Fu Ou-Yang, Nina Lapke, Kai-Che Tung, Yen-Kung Chen, Yuh-Yu Chou, and Shu-Jen Chen

endocrine therapy with goserelin and tamoxifen. This regimen was continued for 2 years until the patient experienced relapse with multiple lung metastases. She received various therapies over the next 4.5 years, including chemotherapy, endocrine therapy

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Lauren Nye, Timothy K. Huyck, and William J. Gradishar

-CSF) with each cycle and the lack of safety data on G-CSF in pregnancy. Tamoxifen and trastuzumab are contraindicated in pregnancy because of the high frequency of congenital abnormalities and poor fetal outcomes. 15 , 17 – 19 Radiation therapy may be a

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Susan Lester

cancer. 10 If the rate of unrelated cancers in the opposite breast is the same as those in the same breast, then approximately half of the ipsilateral recurrences could be biologically new cancers. The greater effectiveness of radiation, tamoxifen, and

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Erica L. Mayer, Nancy U. Lin, and Harold J. Burstein

trastuzumab: a clinically active regimen [abstract] . J Clin Oncol 2005 ; 23 ( suppl 1 ): Abstract 559 . 68. Chu I Blackwell K Chen S . The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell

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Courtney P. Williams, Andres Azuero, Kelly M. Kenzik, Maria Pisu, Ryan D. Nipp, Smita Bhatia, and Gabrielle B. Rocque

the risk of death compared with standard chemotherapy, 27 and overtreatment with lumpectomy plus tamoxifen and radiation therapy has shown no benefit compared with lumpectomy plus adjuvant therapy with tamoxifen alone. 28 In our study of patients