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New Therapies for Ovarian Cancer

David M. O’Malley

ICON7. 1 , 2 A 3-arm trial that enrolled 1,873 patients with newly diagnosed stage III–IV ovarian cancer, GOG-0218 randomly assigned patients 1:1 to carboplatin/paclitaxel followed by placebo maintenance therapy; carboplatin/paclitaxel

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Metastatic Anal Carcinoma: The Role of Radiotherapy

Yi-Jen Chen

) for Anal Carcinoma recommend using 5-FU/cisplatin, carboplatin/paclitaxel, or FOLFOX (5-FU/leucovorin/oxaliplatin) as first-line treatment for MAC. 2 The recently reported randomized, international, multicenter, phase II InterAACT study found that

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Gastric and Esophageal Cancers: Guidelines Updates

Presented by: Crystal S. Denlinger, Kristina A. Matkowskyj, and Mary F. Mulcahy

treatment options now exist that come on the heels of several negative phase II studies: the TyTAN trial of paclitaxel + lapatinib, 6 the GATSBY trial of trastuzumab emtansine (T-DM1) versus a taxane, 7 and the T-ACT trial of paclitaxel + trastuzumab. 8

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Role of Immunotherapy in Triple-Negative Breast Cancer

Tanya E. Keenan and Sara M. Tolaney

atezolizumab and nab-paclitaxel (NCT01375842) showed a promising ORR of 39.4% in 33 patients, also treated with 0 to 2 prior lines, 27 perhaps related to the ability of taxanes to promote toll-like receptor activity and dendritic cell activation. 28 The

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Chemo- and Radiotherapy in Adjuvant Management of Optimally Debulked Endometrial Cancer

David Scott Miller, Gini Fleming, and Marcus E. Randall

paclitaxel: a Gynecologic Oncology Group study . Gynecol Oncol 2009 ; 112 : 543 – 552 . 13 Fleming GF Brunetto VL Cella D . Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial

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Practicing What We Preach!

Robert J. Morgan Jr

improvement in OS with less toxicity, because by the time it was published paclitaxel had already been proven to be a superior second agent, and the oncology community felt that intraperitoneal chemotherapy was not necessary in the age of the taxanes. Annual

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CRE24-035: Pembrolizumab-Induced Hemophagocytic Lymphohistiocytosis in a Patient With Breast Cancer: A Case Report and Systematic Review of the Literature

Charlotte S. Walmsley, Michael Andersen Jr., Barbara Lam, Deepa Rangachari, Shana Berwick, and Rushad Patell

stage IIIC triple negative breast cancer treated presented to the emergency room with two days of diarrhea and fever. She had previously received treatment with neoadjuvant chemoimmunotherapy (carboplatin, paclitaxel, doxorubicin, cyclophosphamide, and

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Lessons From Adaptive Randomization: Spying the I-SPY2 Trial in Breast Cancer

Bishal Gyawali and Saroj Niraula

.gov identifier: NCT01042379 ). The arms consist of one common control arm of standard neoadjuvant chemotherapy with paclitaxel (with an alternate control arm of paclitaxel + trastuzumab or pertuzumab + trastuzumab if HER2-positive) against which other

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Oncology Research Program

scientific peer-review process and are overseen by the ORP. NCCN-sponsored studies funded through the grant mechanism are highlighted below. A Phase I/II Study of Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy Followed by Standard

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NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019

Featured Updates to the NCCN Guidelines

Deborah K. Armstrong, Ronald D. Alvarez, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Jonathan S. Berek, Lee-may Chen, Mihaela Cristea, Marie DeRosa, Adam C. ElNaggar, David M. Gershenson, Heidi J. Gray, Ardeshir Hakam, Angela Jain, Carolyn Johnston, Charles A. Leath III, Joyce Liu, Haider Mahdi, Daniela Matei, Michael McHale, Karen McLean, David M. O’Malley, Richard T. Penson, Sanja Percac-Lima, Elena Ratner, Steven W. Remmenga, Paul Sabbatini, Theresa L. Werner, Emese Zsiros, Jennifer L. Burns, and Anita M. Engh

NACT Several prospective trials have explored whether adding bevacizumab to platinum-based regimens improves outcomes for patients treated with NACT. Preliminary results from GEICO 1205/NOVA found that adding bevacizumab to a standard carboplatin/paclitaxel