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NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W.T. Pisters, Chandrajit P. Raut, Richard F. Riedel, Scott Schuetze, Hema M. Sundar, Jonathan C. Trent, and Jeffrey D. Wayne

tract. In these cases, familial GIST should be considered, which is typically associated with interstitial cell of Cajal hyperplasia within myenteric plexus. Most GISTs show 1 of 3 histologic patterns: spindle cell type (70%; Figure 1 ), predominantly