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Long-Term Patterns of Oral Anticancer Agent Adoption, Duration, and Switching in Patients With CML

Matthew P. Banegas, Donna R. Rivera, Maureen C. O’Keeffe-Rosetti, Nikki M. Carroll, Pamala A. Pawloski, David C. Tabano, Mara M. Epstein, Kai Yeung, Mark C. Hornbrook, Christine Lu, and Debra P. Ritzwoller

improvements in prognosis, with a 50% decrease in the mortality rate from 2000 to 2015. 2 The life expectancy of patients with CML is approaching that of the general population. 3 Imatinib, an orally administered tyrosine kinase inhibitor (TKI), was approved

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Prostate Cancer Screening and Determining the Appropriate Prostate-Specific Antigen Cutoff Values

William J. Catalona and Stacy Loeb

men with a life expectancy less than 10 years. Similarly, the updated NCCN Prostate Cancer Early Detection Guidelines state that “screening in men over 75 years should be considered individually.” 17 The authors believe that this represents a more

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Changes in Prognostic Beliefs of Patients With Metastatic Cancer and Their Association With Changing Health Status

Isabella Gupta, Eric Andrew Finkelstein, Semra Ozdemir, and Chetna Malhotra

their prognosis and vice versa. 18 As patients’ life expectancy increases with advanced therapies and their health status fluctuates over this longer period, it is possible that their prognostic beliefs also change over time. However, most research on

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Communicating Treatment Options to Older Patients: Challenges and Opportunities

Arti Hurria

We’ve been hearing that the United States population is aging and that the number of older adults is expected to double between 2010 and 2030, as life expectancy increases and “baby boomers” reach age 65. These forecasts seemed like they were far

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NCCN Guidelines Update: Evolving Radiation Therapy Recommendations for Breast Cancer

Kilian E. Salerno

. Clinicians should assess individual patient risk for recurrence and apply RNI accordingly, considering age, life expectancy, comorbidities, tumor size, lymphovascular invasion, number and size of positive lymph nodes, response to neoadjuvant chemotherapy

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Predictors of Guideline Treatment Nonadherence and the Impact on Survival in Patients With Colorectal Cancer

Robert B. Hines, Alina Barrett, Philip Twumasi-Ankrah, Dominique Broccoli, Kimberly K. Engelman, Joaquina Baranda, Elizabeth A. Ablah, Lisette Jacobson, Michelle Redmond, Wei Tu, and Tracie C. Collins

CRC within the context of comorbidity burden and life expectancy is a major challenge to delivering high-quality cancer care. 21 , 22 In addition to age and comorbidity, race and socioeconomic status (SES) are associated with receipt of CRC treatment

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Roundtable—The Changing Oncology Landscape: Evolution or Revolution?

Roy Beveridge, John Fox, Susan A. Higgins, Martin Kohn, John J. Mahoney, Lee N. Newcomer, Andrew von Eschenbach, and Clifford Goodman

patients, “life expectancy or overall survival may not be the most valuable thing,” revealed Dr. Fox. The true wishes of patients in terms of the quality of their survival must be reprioritized in clinical decision-making. The care provided to patients

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Monitoring Response to Tyrosine Kinase Inhibitor Therapy, Mutational Analysis, and New Treatment Options in Chronic Myelogenous Leukemia

Jerald P. Radich

can undergo transplant before they progress to advanced phase disease. He also suggested discussing the possibility of transplant with these patients. It can take 4 months or so to find a donor, and patients in blast crisis have a short life expectancy

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Counterpoint: Successes in the Pursuit of Precision Medicine: Biomarkers Take Credit

Shumei Kato, Vivek Subbiah, and Razelle Kurzrock

-normal life expectancy. Another relevant example is the discovery of mutated KIT in gastrointestinal stromal tumors (GIST), a malignancy once considered to have a near-zero response rate to any treatment tried. Kit inhibitors have proven to be

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Can Therapy of Hepatitis C Affect the Development of Hepatocellular Carcinoma?

Laura M. Kulik

interferon therapy modified by pre-treatment viral load in cirrhotic patients. Tokyo-Chiba Hepatitis Research Group . Liver 2000 ; 20 : 271 – 280 . 37. Yoshida H Arakawa Y Sata M . Interferon therapy prolonged life expectancy among chronic