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John G. Phillips, Theodore S. Hong, and David P. Ryan

microenvironment and tumor cell type–specific effects. 38 Bevacizumab is an anti-VEGF monoclonal antibody initially developed in colorectal cancer. Increased VEGF levels in colorectal cancers have been shown to predict poor outcomes. 39 , 40 Bevacizumab

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Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke, and Sandy Srinivas

December 2005, 6 new drugs have been approved by the FDA for the treatment of metastatic RCC. The currently available targeted agents can be classified as VEGF-pathway targeting agents (bevacizumab, sunitinib, sorafenib, and pazopanib) and mTOR

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Benjamin A. Weinberg

bevacizumab in patients with KRAS exon 2 wild-type mCRC, the longest overall survival was seen in the study arm that included patients with left-sided tumors treated with cetuximab (36.0 months), followed by the left-sided tumors treated with bevacizumab arm

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Harold J. Burstein

specifically recommended against in the NCCN Guidelines because they were known to be ineffective or to lack any efficacy data. These included bevacizumab beyond progression with bevacizumab, capecitabine after fluoropyridimidine regimens, and panitumumab or

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Bevacizumab for Patients With Advanced Cancers Principal Investigator: Apostolia M. Tsimberidou, MD, PhD Conditions: Advanced cancers Institutions: The University of Texas MD Anderson Cancer Center Designed as a standard 3 + 3 study with expansion

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subsequent therapy of kidney cancer with predominant clear cell histology, the category for bevacizumab was changed from a category 2B to category 2A following cytokine therapy and category 2B following tyrosine kinase inhibitor. For systemic therapy of

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Eric Jonasch

Kidney Cancer, first-line options with randomized phase II evidence of benefit include the FDA-approved agents sunitinib, pazopanib, and the combination of bevacizumab and interferon. Furthermore, temsirolimus is indicated for patients with a poor

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public interest and attention, Dr. Carlson reviewed the research and evidence leading to the decision for the NCCN Guidelines Panel to reaffirm its existing recommendation of bevacizumab (Avastin, Genentech/Roche) in combination with paclitaxel (Taxol

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Robert W. Carlson and on behalf of the NCCN Breast Cancer Panel

–Vascular Endothelial Growth Factor Therapy Perhaps no other area of breast oncology has been as controversial over the past decade as the potential role of bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor, in combination with

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NCCN Guidelines Insights: Cervical Cancer, Version 1.2020

Featured Updates to the NCCN Guidelines

Nadeem R. Abu-Rustum, Catheryn M. Yashar, Sarah Bean, Kristin Bradley, Susana M. Campos, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Robert Giuntoli II, Ernest Han, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Rachel Sisodia, Todd Tillmanns, Stefanie Ueda, Renata Urban, Emily Wyse, Nicole R. McMillian, and Angela D. Motter

regimens (eg, bevacizumab, pembrolizumab) in combination with, or as alternatives to, existing first- and second-line treatment options has led to improved outcomes in some patients. These NCCN Guidelines Insights focus on recent changes to first- and