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Pharmacogenetics of Tamoxifen: Who Should Undergo CYP2D6 Genetic Testing?

Michaela J. Higgins, James M. Rae, David A. Flockhart, Daniel F. Hayes, and Vered Stearns

adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial . Lancet Oncol 2008 ; 9 : 45 – 53 . 48 Coates AS Keshaviah A Thurlimann B . Five years of letrozole compared with tamoxifen as initial adjuvant therapy for

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Management of Renal Cell Carcinoma

Presented by: Michael Serzan

Adjuvant Therapy for Clear Cell Renal Cell Carcinoma Vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKIs) have been extensively studied in the adjuvant setting for patients with renal cell carcinoma (RCC). Although

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Ten Years of Progress in Melanoma

John A. Thompson

-positives. PET/CT may be more useful than conventional CT in the workup of patients who have relatively high pretest probabilities of occult metastatic disease (eg, patients with stage IIIB and IIIC melanoma). Treatment Adjuvant Therapy High

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Updates to the Management of Cutaneous Melanoma

Presented by: Douglas B. Johnson

Practice Guidelines in Oncology (NCCN Guidelines) for Bladder Cancer, as well as the supporting clinical data at the NCCN 2024 Annual Conference. Neoadjuvant Versus Adjuvant Therapy: Clinical Data Dr. Johnson began by discussing critical decisions in

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Clinical Consequences of Altering the Definition of HER2-Positive Breast Cancer to Exclude Group 2, HER2-Negative Disease

Steven Sorscher

HER2 copy number is less than 4 signals/cell is that….” 2 Based on the pre-2018 ASCO/CAP HER2 classification, whether being used as adjuvant therapy or therapy for metastatic HER2-positive disease, the FDA-approved anti-HER2 therapies offer truly

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Validation of the PREDICT Prognostication Tool in US Patients With Breast Cancer

Nickolas Stabellini, Lifen Cao, Christopher W. Towe, Megan E. Miller, Artur H. Sousa-Santos, Amanda L. Amin, and Alberto J. Montero

,700 breast cancer–related deaths are expected. 2 Due to steady progress in early breast cancer diagnosis and treatment, 5-year overall survival (OS) continues to improve. 3 Accurate estimates of survival and the impact of different adjuvant therapies in

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Systemic Management of Colorectal Cancer

Wells A. Messersmith

treatment with the best chance of success. Adjuvant Therapy Although 11 agents have been approved by the FDA for CRC, only 3 are used in the adjuvant setting (fluorouracil [5-FU], capecitabine, and oxaliplatin) and only 2 (cetuximab and panitumumab

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Highlights of the NCCN Oncology Research Program

) colorectal cancer who have received prior treatment with a fluoropyrimidine (5-FU or capecitabine) and oxaliplatin or who have experienced a recurrence within 12 months of adjuvant therapy with a regimen that included oxaliplatin. For study purposes, a cycle

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BPI20-014: Clinical Pathway and Education Implementation to Support Guideline Adherent Breast Cancer Care for Rural Women Under Age 50

Robin M. Lally, Elizabeth Reed, and Roksana Zak

-treatment assessments, consultations, considerations, neoadjuvant and adjuvant therapy and survivorship care. Oncology provider survey return rate was 25%. Results indicated satisfaction but changes needed to pathway design and content. Modified pathways were

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HSR20-102: Quality Outcomes in Colon Cancer

Michelle Moskal and Neeharika S. Makani

, only 6.3% of high risk stage II and 45.5% of stage III patients received adjuvant therapy. Data showed 100% compliance with initiation of adjuvant 5-FU based chemotherapy within 12 weeks post surgery, which is recommended in high risk stage II and III