reason that in the adjuvant setting, we could probably identify diagnostic tools to predict outcome, and thus need for adjuvant treatment, across all disease sites. Actually, folks are working on that with a fair bit of success. But adjuvant therapy is
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Genomic Medicine Takes the Stage, Again!
Margaret Tempero
CLO23-040: Electrocardiographic Findings in Cancer Patients Receiving Chemotherapy From the Colombian Coffee Triangle Region
Andres Garcia, David Medina, Alejandra Palacio, Andrés Vallejo, Luz Adriana Díaz, Juan Darío Franco, Tatiana Taborda, and María José Rojas
-IV). In chemotherapy indications, 31.3% were prescribed for palliative care, with the same percentage for adjuvant therapy and 18% for neoadjuvant and hormonal treatment, respectively. The most frequently prescribed antineoplastic agents were taxanes
Pharmacogenetics of Tamoxifen: Who Should Undergo CYP2D6 Genetic Testing?
Michaela J. Higgins, James M. Rae, David A. Flockhart, Daniel F. Hayes, and Vered Stearns
adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial . Lancet Oncol 2008 ; 9 : 45 – 53 . 48 Coates AS Keshaviah A Thurlimann B . Five years of letrozole compared with tamoxifen as initial adjuvant therapy for
Management of Renal Cell Carcinoma
Presented by: Michael Serzan
Adjuvant Therapy for Clear Cell Renal Cell Carcinoma Vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKIs) have been extensively studied in the adjuvant setting for patients with renal cell carcinoma (RCC). Although
Ten Years of Progress in Melanoma
John A. Thompson
-positives. PET/CT may be more useful than conventional CT in the workup of patients who have relatively high pretest probabilities of occult metastatic disease (eg, patients with stage IIIB and IIIC melanoma). Treatment Adjuvant Therapy High
Updates to the Management of Cutaneous Melanoma
Presented by: Douglas B. Johnson
Practice Guidelines in Oncology (NCCN Guidelines) for Bladder Cancer, as well as the supporting clinical data at the NCCN 2024 Annual Conference. Neoadjuvant Versus Adjuvant Therapy: Clinical Data Dr. Johnson began by discussing critical decisions in
Clinical Consequences of Altering the Definition of HER2-Positive Breast Cancer to Exclude Group 2, HER2-Negative Disease
Steven Sorscher
HER2 copy number is less than 4 signals/cell is that….” 2 Based on the pre-2018 ASCO/CAP HER2 classification, whether being used as adjuvant therapy or therapy for metastatic HER2-positive disease, the FDA-approved anti-HER2 therapies offer truly
Validation of the PREDICT Prognostication Tool in US Patients With Breast Cancer
Nickolas Stabellini, Lifen Cao, Christopher W. Towe, Megan E. Miller, Artur H. Sousa-Santos, Amanda L. Amin, and Alberto J. Montero
,700 breast cancer–related deaths are expected. 2 Due to steady progress in early breast cancer diagnosis and treatment, 5-year overall survival (OS) continues to improve. 3 Accurate estimates of survival and the impact of different adjuvant therapies in
Systemic Management of Colorectal Cancer
Wells A. Messersmith
treatment with the best chance of success. Adjuvant Therapy Although 11 agents have been approved by the FDA for CRC, only 3 are used in the adjuvant setting (fluorouracil [5-FU], capecitabine, and oxaliplatin) and only 2 (cetuximab and panitumumab
Highlights of the NCCN Oncology Research Program
) colorectal cancer who have received prior treatment with a fluoropyrimidine (5-FU or capecitabine) and oxaliplatin or who have experienced a recurrence within 12 months of adjuvant therapy with a regimen that included oxaliplatin. For study purposes, a cycle